&lt;p&gt;MiR-483 Targeted SOX3 to Suppress Glioma Cell Migration, Invasion and Promote Cell Apoptosis&lt;/p&gt;

Lu, Shujing; Yu, Zhengping; Zhang, Xia; Sui, Ling-ling

doi:10.2147/ott.s240619

Cited by 10 publications

(25 citation statements)

References 28 publications

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“…To the best of our knowledge, in this study, miR1258 was found to be highly expressed in preterm infants with BPD for the first time and was identified as a risk factor for BPD. Furthermore, miR-483 may inhibit the proliferation and metastasis of glioma and colorectal cancer [ 44 , 45 ]. It has been demonstrated that miR-483 targets insulin-like growth factor 1 (IGF1) and downregulates the expression of key proteins in the PI3K/AKT signalling pathway, thereby inhibiting myogenic cell proliferation and differentiation [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Functional Analysis of Bronchopulmonary Dysplasia-Related Neuropeptides in Preterm Infants and miRNA-Based Diagnostic Model Construction

Zhang¹,

Kong

Zhang³

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Bronchopulmonary dysplasia (BPD) has a high mortality rate. This study was aimed at identifying and analysing the risk factors associated with BPD using bioinformatic and mechanical analyses and establishing a predictive model to assess the risk of BPD in preterm infants. Methods. We identified differentially expressed RNAs via the intersection of miRNAs between datasets. Online analysis tools were used to predict genes targeted by differentially expressed miRNAs (DEmiRNAs) and to generate and visualise competing endogenous RNA (ceRNA) coexpression networks. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were subsequently performed on the DEmiRNAs. In addition, an intersection analysis was performed on mRNA and neuropeptide-related genes in the ceRNA network. DEmiRNAs associated with BPD and those involved in ceRNA networks were used to establish a diagnostic prediction model. The GSE108604 dataset was used as a validation set to verify the model. Results. A total of 26 DEmiRNAs were identified from the tracheal aspirates (TAs) of patients with BPD and healthy controls. In addition, a total of 1076 DEmRNAs were obtained from the GSE8586 dataset. Functional enrichment analysis of DEmRNAs revealed an abnormal reduction in mitochondrial-related activity and cellular responses to oxidative stress in patients with BPD. The neuropeptide-related genes OPRL1 and NPPA were found to be upregulated in BPD samples. Eventually, hsa-miR-1258, hsa-miR-298, hsa-miR-483-3p, and hsa-miR-769-5p were screened out and used to establish the prediction model. Calibration curves and detrended correspondence analysis (DCA) revealed that the model had good clinical applicability. Conclusions. The prediction model provided a simple method for individualised assessment, early diagnosis, and prevention of BPD risk in preterm infants.

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Section: Discussionmentioning

confidence: 99%

Functional Analysis of Bronchopulmonary Dysplasia-Related Neuropeptides in Preterm Infants and miRNA-Based Diagnostic Model Construction

Zhang¹,

Kong

Zhang³

et al. 2022

Computational and Mathematical Methods in Medicine

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“…In contrast, previous studies have shown that overexpression of SOX3 is associated with poor overall survival in gastric cancer, 42 breast cancer 43 and adult de novo acute myeloid leukaemia. 44 Lu S et al 45 indicated that overexpression of SOX3 predicts a poor outcome in GBM patients; and, Sa JK et al 46 found SOX3 is associated with tumour invasiveness, malignancy and poor prognosis in GBM patients. Vicentic et al 47 found SOX3 can accelerate the malignant behaviour of GBM cells.…”

Section: Discussionmentioning

confidence: 99%

Expression and significance of SOX B1 genes in glioblastoma multiforme patients

Pan

Liang

Wang³

et al. 2021

J Cellular Molecular Medi

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Glioblastoma multiforme (GBM) is the most common, malignant and high-grade brain tumour. 1,2 The WHO classification system divides glioma into 4 subtypes and GBM as grade 4 glial tumour has the worst prognosis. 3 The intra-and intertumoral genetic and epigenetic heterogeneity observed in GBM highlights the complexity of cancer. 4 The median survival of GBM patients is around 12-15 months, even with

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“…Their analysis revealed that all three SOXB1 members were upregulated in GBM to varying degrees, compared to the normal tissues, identifying only SOX3 as a potential prognostic biomarker whose increased expression correlated with better overall survival [ 38 ]. In contrast, Lu et al revealed a significantly higher expression level of SOX3 in glioma compared with the normal tissues and correlated its overexpression with poor outcomes [ 40 ]. Our previous study revealed a higher level of SOX3 expression in a subset of primary GBM samples compared to non-tumoral brain tissues and in a patient-derived GSC culture, suggesting that SOX3 is required to maintain GSCs in an undifferentiated state [ 41 ].…”

Section: The Role Of Sox Genes In Glioblastomamentioning

confidence: 99%

Crosstalk between SOX Genes and Long Non-Coding RNAs in Glioblastoma

Stevanović

Kovacevic-Grujicic

Petrović

et al. 2023

IJMS

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Glioblastoma (GBM) continues to be the most devastating primary brain malignancy. Despite significant advancements in understanding basic GBM biology and enormous efforts in developing new therapeutic approaches, the prognosis for most GBM patients remains poor with a median survival time of 15 months. Recently, the interplay between the SOX (SRY-related HMG-box) genes and lncRNAs (long non-coding RNAs) has become the focus of GBM research. Both classes of molecules have an aberrant expression in GBM and play essential roles in tumor initiation, progression, therapy resistance, and recurrence. In GBM, SOX and lncRNAs crosstalk through numerous functional axes, some of which are part of the complex transcriptional and epigenetic regulatory mechanisms. This review provides a systematic summary of current literature data on the complex interplay between SOX genes and lncRNAs and represents an effort to underscore the effects of SOX/lncRNA crosstalk on the malignant properties of GBM cells. Furthermore, we highlight the significance of this crosstalk in searching for new biomarkers and therapeutic approaches in GBM treatment.

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<p>MiR-483 Targeted SOX3 to Suppress Glioma Cell Migration, Invasion and Promote Cell Apoptosis</p>

Cited by 10 publications

References 28 publications

Functional Analysis of Bronchopulmonary Dysplasia-Related Neuropeptides in Preterm Infants and miRNA-Based Diagnostic Model Construction

Functional Analysis of Bronchopulmonary Dysplasia-Related Neuropeptides in Preterm Infants and miRNA-Based Diagnostic Model Construction

Expression and significance of SOX B1 genes in glioblastoma multiforme patients

Crosstalk between SOX Genes and Long Non-Coding RNAs in Glioblastoma

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