<p>Neuroprotective effect and mechanism of baicalin on Parkinson’s disease model induced by 6-OHDA</p>

Abstract

Objective: This research was aimed to investigate the effects of baicalin on 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease (PD) and the main mechanism of baicalin based on metabolomics.Methods: The rat model of PD was induced by 6-OHDA. The protective effects of baicalin on rat model of PD were evaluated by open field test and rotarod test. The anti-PD efficacy of baicalin was evaluated by examining the morphologic changes of neurons and the level of monoamine neurotransmitters in the striatum, the number and morphology of tyrosine hydroxylase (TH)-positive neurons, and oxidative stress. Combined with metabolomics methods, the pharmacodynamic mechanism of baicalin on PD pathogenesis was also explored. Results: Baicalin treatment improved the rod time and voluntary movement in rat model of PD (P<0.05) by the open field test and rotarod test. In addition, baicalin also protected from oxidative stress injury (P<0.05), and regulated the content of monoamine neurotransmitters dopamine, 3,4-dihydroxyphenylacetic acid, 5-hydroxytryptamine, and 5-hydroxyindoleacetic acid (P<0.05) and the number and morphology of TH-positive cells in 6-OHDA-induced PD model rats. By metabolomics, multivariate statistical analysis, and receiver operating characteristic curve analysis, we found that two metabolites N-acetyl aspartic acid and glutamic acid had a good diagnostic value. Quantitative analysis of metabolites showed a regulatory function of baicalin. Conclusion: Baicalin has significant protective effect on 6-OHDA-induced PD rats, which may play a protective role through an antioxidant, promoting the release of neurotransmitters and regulating the metabolism of N-acetyl aspartate and glutamate.

Baicalin and Geniposide Inhibit Polarization and Inflammatory Injury of OGD/R-Treated Microglia by Suppressing the 5-LOX/LTB4 Pathway

“…As the main active ingredient of huangqin, baicalin (BC), has been proven to have anti-bacterial and anti-inflammatory properties. It is widely used in the treatment of enteritis [10,11], influenza [12][13][14], cerebrovascular diseases [15,16]. BC has been shown to reduce cerebral infarct volume, and the pathological impairment of ischemic brain tissue has been alleviated in rats with cerebral ischemia, suggesting it has a neuroprotective effect on cerebral ischemia [17,18].…”

The Role of Olfactory System in the Etiogenesis of Parkinson’s Diseases: An Overview

“…43 Baicalin ↓α-synuclein aggregation↑redox potential ↓neurodegeneration ↑Neurogenesis in the olfactory bulb. 44 Estrogen ↓nigral neuronal damage Controversial results as earlier estrogen was found to be an olfactory protectant and later studies suggested the opposite. 45 Omega-3 supplements ↓oxidational damage Protective against olfactory loss.…”

Therapeutic Properties of Baicalin - A Literature Review

“…Furthermore, Tuan et al (2014) found that the main carotenoids in Scutellaria baicalensis were lutein (67) and β-carotene (68), and the leaves contained a lot of carotene. Lately, it was reported that three lignan glycosides (69)(70)(71) from the roots of Scutellaria baicalensis were isolated by spectral detection and qualitative chemical testing.…”

“…Skin autoimmune diseases, such as psoriasis vulgaris, alopecia areata and systemic lupus erythematosus (SLE) affects approximately 200 million people globally. BAI and ex vivo expanded Foxp3+ regulatory T cells were recently reported to be promising therapeutics strategy for SLE treatment since it was able to reduce Tfh cell differentiation, IL-21 production and mTOR activation while promote the differentiation of Foxp3+ regulatory T cell (Yang et al, 2019). On the other hand, BAE demonstrated reno-protective effect in a mouse model of lupus nephritis, which is regarded as a representative manifestation in SLE.…”