<p>Neutrophil-to-Lymphocyte Ratio and Its Changes are Related to Grade II–IV Glioma Recurrence</p>

Abstract

Objective: To explore whether the neutrophil-to-lymphocyte ratio (NLR) and its changes are related to tumor recurrence in grade II-IV glioma patients. Methods: One hundred patients who underwent two surgeries (first for diagnosis and the second for recurrence) were retrospectively analyzed. Complete blood count was obtained preoperatively before any treatment. Basic NLR (before the first surgery) and NLR changes were calculated. Tumor recurrence was evaluated by progression-free survival (PFS) using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to determine the potential prognostic factors for PFS. Results: The PFS of patients with high basic NLR (≥4) (median 9 months) was shorter than that of patients with low basic NLR (<4) (median 23 months) (P = 0.004). Univariate and multivariate analyses both showed that basic NLR (before the first surgery) (≥4 vs <4) was an independent predictor of PFS (P = 0.011). The PFS is also varied with NLR changes before two surgeries (P < 0.05). The PFS of patients with two low NLR (<4) at both initial surgical resection and section for tumor recurrence had the longest PSF. The patients with two high NLR (≥4) at both initial surgical resection and section for tumor recurrence had the shortest PSF. The patients with one high NLR (≥4) at initial surgical resection or section for tumor recurrence had an average PSF. Multivariate analysis showed that the change of NLR was of prognostic significance independent of glioma grade. Conclusion: We showed both basic NLR and NLR changes could predict the recurrence of glioma, but the change of NLR is more accurate than that of basic NLR. The current research not only provides a simple and feasible method for clinical judgment of glioma recurrence but also provides a new idea for exploring the mechanism of glioma recurrence.

Neutrophil-To-Lymphocyte Ratio Is Prognostic in Recurrent Glioblastoma Multiforme Treated with Bevacizumab Plus Irinotecan

“…However, we demonstrated that the pretreatment H-NLR values were independently associated with significantly diminished OS times (63.0 vs 90% at 6-months) compared with their L-NLR counterparts. Recently systemic inflammationrelated indices have been shown to accurately predict poorer prognoses in GBM patients either measured at the time of diagnosis, after initial neurosurgery, before the adjuvant therapy and before SNS in relapsed patients [16][17][18][19][23][24][25][26][27][28][29]. However, to our best information, there were no data in the comparative literature for R-GBM patients who underwent salvage BEVIRI during the preparation of this manuscript.…”

Comprehensive analysis of epigenetics regulation, prognostic and the correlation with immune infiltrates of GPX7 in adult gliomas

“…Most glioma patients have a strong neutrophilia 143 , 144 , and neutrophil infiltration at the tumor site has been associated with decreased overall survival (OS), tumor recurrence in grade 2–4 glioma patients and brain metastasis 145 . Circulating neutrophils are recruited at the tumor site by CXCL8 produced by FasL triggering on glioma cells 146 , 147 or by the Migration Inhibitory Factor (MIF) produced by glioma cancer stem cells 148 .…”

Neutrophil extracellular traps induce a hypercoagulable state in glioma

“…12-14 Moreover, neutrophil counts have previously been associated with the prognosis of glioma patients. [15][16][17][18] NETs have been recently reported in glioma tissues and their expression was correlated with glioma grades. 19,20 In our study, plasma levels of NETs were detected in glioma patients.…”

“…[12][13][14] Neutrophil counts have previously been associated with the prognosis of glioma patients. [15][16][17][18][19] Neutrophil extracellular traps (NETs) have been recently reported in glioma tissues and their expression was correlated with glioma grades. 20 NETs are web-like DNA-containing structures released from activated neutrophils, which are comprised of decondensed chromatin and proteases such as myeloperoxidase (MPO) and neutrophil elastase (NE).…”