<p>Obesity, adipocyte hypertrophy, fasting glucose, and resistin are potential contributors to nonalcoholic fatty liver disease in South Asian women</p>

Abstract

Purpose: Nonalcoholic fatty liver disease (NAFLD) is often referred to as the hepatic manifestation of the metabolic syndrome. The relationship between body weight, NAFLD, and insulin resistance is not well characterized in humans. Additionally, it is unclear why South Asians develop these complications at lower levels of obesity compared to their Western counterparts. Patients and methods: To address this question, we performed a cross-sectional study using a convenience sample of Sri Lankan adult females (n=34) and collected anthropometric data, adipose tissue specimens (for histology), and fasted serum samples (for metabolic and inflammatory markers). Hepatic steatosis was assessed by ultrasound scanning and used to classify participants as NAFL 0, NAFL 1, and NAFL 2. Results: Waist circumference significantly increased with increasing NAFL grade. Participants with NAFL had significantly higher body mass index, hip circumference, and fasting plasma glucose, as well as a higher mean adipocyte area in both abdominal subcutaneous and visceral areas, indicating a higher degree of adipocyte hypertrophy associated with fatty liver. There were, however, no differences in measures of dyslipidemia. Of the multiple adipokines measured, resistin was the only proinflammatory adipokine significantly elevated in NAFL 2. Conclusion: These findings indicate that measures of adiposity, fasting serum glucose, and resistin may be important indicators of NAFLD in South Asian women.

Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity

“…Adipocyte hypertrophy is an adaptive adipose tissue response to the excess of energy and correlates positively with metabolic syndrome manifestations [ 30 , 31 , 32 , 33 ]. Since, in our study, the curcumin-supplemented diet resulted in body weight and fat mass reduction in mice, we evaluated the effects of curcumin on adipocyte hypertrophy in white epididymal adipose tissue.…”

Association between fasting plasma glucose and nonalcoholic fatty liver disease in a nonobese Chinese population with normal blood lipid levels: a prospective cohort study

“…In 2019, the Taiwanese scholar Hsu CL and his team found an association between FPG and NAFLD in 4000 nonobese people [18]. Additionally, a study from Sri Lanka reported the incidence of NAFLD in 34 local women; after post hoc analysis, it was found that there was a correlation between higher FPG and NAFLD [19]. Similar findings have been reported in China [24]; although these studies have highlighted that there is a positive correlation between FPG and NAFLD, these studies still have some limitations: (1) the adjustment of potential confounding factors, such as LDL-C, ALB, GLB, and DBP, is not sufficient; (2) the participants were not entirely nonobese, and the association between normal lipids and the incidence of NAFLD was not evaluated;…”

“…Recently, some clinical studies from Sri Lanka and Taiwan have reported an association between FPG and the development of NAFLD. The reports argued that higher FPG is a significant risk factor for NAFLD [18,19]. However, the sample size of these studies was relatively small, and similar studies are still lacking.…”

Investigating the Relationship Between Insulin Resistance and Fatty Liver in a Random Population of Tehran

“…Previous studies have shown that FLD, together with type II diabetes and insulin resistance, is associated with a higher risk of death (2). There are limited studies on FLD in Iran (15), and there is a lack of a consensus regarding the relationship between insulin resistance and fatty liver disease (16)(17)(18).…”