&lt;p&gt;Pharmacological Therapy of Osteoporosis: What’s New?&lt;/p&gt;

Iolascon, Giovanni; Moretti, Antimo; Toro, Giuseppe; Gimigliano, Francesca; Liguori, Sara; Paoletta, Marco

doi:10.2147/cia.s242038

Cited by 72 publications

(71 citation statements)

References 41 publications

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“…Some studies revealed also the changing trends: till 2010 [ 12 ] or 2003 [ 14 ], the increase was established and afterwards the decreasing trend was observed. However, one should be aware that fragility fractures are underestimated and undertreated, although pharmacological treatment demonstrated to be effective for reducing their incidence, particularly in secondary prevention care [ 18 ]. Recently, the hip fracture incidence during COVID-19 pandemic was described and the number of hip fractures did not change in comparison with earlier periods [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

The incidence of arm, forearm, and hip osteoporotic fractures during early stage of COVID-19 pandemic

et al. 2021

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The study analyzes whether the COVID-19 pandemic affects the incidence of arm, forearm, and hip fractures. Additionally, the change in the overall cost of those fractures treatment was estimated. During the COVID-19 pandemic, the incidence of arm, forearm, and hip fractures and the cost of fracture management are decreased. Introduction Purposes of the study were to analyze if COVID-19 pandemic influences the incidence of arm, forearm, and hip osteoporotic fractures and to estimate the changes in costs of their management. Methods Data on arm, forearm, and hip fracture incidence were collected for inhabitants aged over 50 years in the district of Tarnowskie Góry and the city of Piekary Śląskie, South Poland, in the early stage of COVID-19 pandemic (77 days, from March 16th to May 31st 2020). These results were compared with the number of fractures noted in years 2015-2019 in the same period of the year. The ratio of analyzed fractures per 100,000 inhabitants was calculated. Results The recorded numbers of fractures of arm, forearm, and hip were 13, 43, and 29, respectively. The respective mean number for fractures reported in corresponding period in 2015-2019 years was 23.6, 52, and 33. The year fracture incidence calculated per 100,000 inhabitants decreased by 45.8%, 18.4%, and 13.4%, respectively. The estimated numbers of avoided fractures extrapolated for the whole country for arm, forearm, and hip were 1722, 1548, and 947, respectively. The total number of avoided fractures was 4217. The expected nationwide cost reduction for the arm, forearm, and hip fracture management was estimated at € 568,260, € 332,820, and € 1,628,840, respectively. The total cost reduction was € 2,529,920 over the period of observation. Conclusion During COVID-19 pandemic, a decrease of arm, forearm, and hip fracture incidence was observed which may result in decrease of total costs for Polish healthcare system.

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Section: Introductionmentioning

confidence: 99%

The incidence of arm, forearm, and hip osteoporotic fractures during early stage of COVID-19 pandemic

et al. 2021

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“…Osteoporosis is considered one of the main health problems in developed countries, considering the high morbidity and mortality of fragility fractures and the resulting economic burden [ 18 ]. The proximal femur is one of the most affected sites by fragility fractures [ 1 ].…”

Section: Resultsmentioning

confidence: 99%

Fractures around Trochanteric Nails: The “Vergilius Classification System”

Toro

Moretti

Ambrosio³

et al. 2021

Advances in Orthopedics

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Introduction. The fractures that occurred around trochanteric nails (perinail fractures, PNFs) are becoming a huge challenge for the orthopaedic surgeon. Although presenting some specific critical issues (i.e., patients’ outcomes and treatment strategies), these fractures are commonly described within peri-implant ones and their treatment was based on periprosthetic fracture recommendations. The knowledge gap about PNFs leads us to convene a research group with the aim to propose a specific classification system to guide the orthopaedic surgeon in the management of these fractures. Materials and Methods. A steering committee, identified by two Italian associations of orthopaedic surgeons, conducted a comprehensive literature review on PNFs to identify the unmet needs about this topic. Subsequently, a panel of experts was involved in a consensus meeting proposing a specific classification system and formulated treatment statements for PNFs. Results and Discussion. The research group considered four PNF main characteristics for the classification proposal: (1) fracture localization, (2) fracture morphology, (3) fracture fragmentation, and (3) healing status of the previous fracture. An alphanumeric code was included to identify each characteristic, allowing to describe up to 54 categories of PNFs, using a 3- to 4-digit code. The proposal of the consensus-based classification reporting the most relevant aspects for PNF treatment might be a useful tool to guide the orthopaedic surgeon in the appropriate management of these fractures.

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“…Romosozumab, an Scl-Ab agent, has completed phase III studies. Romosozumab was found to be able to reduce the threat of vertebral, hip, and other fractures in postmenopausal women suffering from osteoporosis [ 69 , 70 ]. Many studies suggest that Scl-Ab has promising prospects in the treatment of periodontitis.…”

Section: The Altered Secretory Function Of Osteocytes In Periodontitimentioning

confidence: 99%

The roles of osteocytes in alveolar bone destruction in periodontitis

Huang

Xie

et al. 2020

J Transl Med

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Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar bone loss in periodontitis is crucial for understanding its pathogenesis. Classically, bone cells, such as osteoclasts, osteoblasts and bone marrow stromal cells, are thought to dominate the development of bone destruction in periodontitis. Recently, osteocytes, the cells embedded in the mineral matrix, have gained attention. This review demonstrates the key contributing role of osteocytes in periodontitis, especially in alveolar bone loss. Osteocytes not only initiate physiological bone remodeling but also assist in inflammation-related changes in bone remodeling. The latest evidence suggests that osteocytes are involved in regulating bone anabolism and catabolism in the progression of periodontitis. The altered secretion of receptor activator of NF-κB ligand (RANKL), sclerostin and Dickkopf-related protein 1 (DKK1) by osteocytes affects the balance of bone resorption and formation and promotes bone loss. In addition, the accumulation of prematurely senescent and apoptotic osteocytes observed in alveolar bone may exacerbate local destruction. Based on their communication with the bloodstream, it is noteworthy that osteocytes may participate in the interaction between local periodontitis lesions and systemic diseases. Overall, further investigations of osteocytes may provide vital insights that improve our understanding of the pathophysiology of periodontitis.

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<p>Pharmacological Therapy of Osteoporosis: What’s New?</p>

Cited by 72 publications

References 41 publications

The incidence of arm, forearm, and hip osteoporotic fractures during early stage of COVID-19 pandemic

The incidence of arm, forearm, and hip osteoporotic fractures during early stage of COVID-19 pandemic

Fractures around Trochanteric Nails: The “Vergilius Classification System”

The roles of osteocytes in alveolar bone destruction in periodontitis

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