&lt;p&gt;Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization&lt;/p&gt;

You, Di; Li, Kai; Guo, Wenlai; Zhao, Guoqing; Fu, Chen

doi:10.2147/ijn.s216365

Cited by 28 publications

(14 citation statements)

References 63 publications

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“…In our previous study, PLGA material was demonstrated to have no obvious antibacterial activity, thus, PLGA was used as the experimental control group. 49 As shown in Figure 6A , the PDA@PLGA group showed a similar OD value as the PLGA group, indicating that the PDA coating had no obvious effect on the antibacterial properties of the material. After loading AuNPs on the surface of the PLGA scaffolds, the OD value of bacterial solutions decreased to a certain extent, but the decreasing trend was not obvious, and a significant difference was found only when scaffold was co-culture with E coli (P < 0.05).…”

Section: Resultsmentioning

confidence: 76%

Mussel-Inspired Gold Nanoparticle and PLGA/L-Lysine-g-Graphene Oxide Composite Scaffolds for Bone Defect Repair

Fu¹,

Jiang²,

Yang³

et al. 2021

IJN

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Purpose Insufficient biological activity heavily restricts the application and development of biodegradable bone implants. Functional modification of bone implants is critical to improve osseointegration and bone regeneration. Methods In this study, L-lysine functionalized graphene oxide (Lys-g-GO) nanoparticles and polydopamine-assisted gold nanoparticle (AuNPs-PDA) coatings were applied to improve the biological function of PLGA scaffold materials. The effects of Lys-g-GO nanoparticles and AuNPs-PDA functionalized coatings on the physicochemical properties of PLGA scaffolds were detected with scanning electron microscopy (SEM), contact angle measurement, and mechanical testing instruments. In vitro, the effects of composite scaffolds on MC3T3-E1 cell proliferation, adhesion, and osteogenic differentiation were studied. Finally, a radial defect model was used to assess the effect of composite scaffolds on bone defect healing. Results The prepared AuNPs-PDA@PLGA/Lys-g-GO composite scaffolds exhibited excellent mechanical strength, hydrophilicity and antibacterial properties. In vitro, this composite scaffold can significantly improve osteoblast adhesion, proliferation, osteogenic differentiation, calcium deposition, and other cell behaviour. In vivo, this composite scaffold can significantly promote the new bone formation and collagen deposition in the radial defect site and presented good biocompatibility. Conclusion The combination of bioactive nanoparticles and surface coatings shows considerable potential to enhance the osseointegration of bone implants.

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Section: Resultsmentioning

confidence: 76%

Mussel-Inspired Gold Nanoparticle and PLGA/L-Lysine-g-Graphene Oxide Composite Scaffolds for Bone Defect Repair

Fu¹,

Jiang²,

Yang³

et al. 2021

IJN

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“…[ 111 ] Under external ES, the scaffold dressing exhibits high bioactivity, supporting myoblast adhesion and strengthening cell responses, further enhancing wound healing ( Table 5 ). [ 110,112–123 ] Another series of conductive hydrogels that are based on dopamine‐grafted hyaluronic acid and polydopamine‐coated reduced graphene oxide (rGO), which are crosslinked by oxidative coupling of catechol groups using an H 2 O 2 /horseradish peroxidase catalytic system, have been prepared as materials for dressing wounds (Figure 6b). [ 115 ] The as‐prepared composite hydrogels have adhesive, hemostatic, and antioxidant properties as well as mechanical properties that are similar to those of human skin.…”

Section: Electroactive Wound Dressings That Incorporate Inorganic Conmentioning

confidence: 99%

Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives

Korupalli

Nguyen

et al. 2020

Adv Healthcare Materials

112

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The use of conductive materials to promote the activity of electrically responsive cells is an effective means of accelerating wound healing. This article focuses on recent advancements in conductive materials, with emphasis on overviewing their incorporation with non‐conducting polymers to fabricate electroactive wound dressings. The characteristics of these electroactive dressings are deliberated, and the mechanisms on how they accelerate the wound healing process are discussed. Potential directions for the future development of electroactive wound dressings and their potential in monitoring the course of wound healing in vivo concomitantly are also proposed.

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“…There are many more studies on functional wound dressings. Considering in vivo studies after 2019, electrically conductive dressings containing graphene oxide (GO), 244 polypyrrole, 245,246 MXene, 247 and liquid metal integrated with a microneedle patch 248 succeeded in accelerating wound healing with external electrical stimulation. In addition, the application of conductive dressings carrying GO, 249–252 carbon nanotubes, 253,254 polypyrrole, 255 and polyaniline 256 to the skin has been reported to enhance wound healing in vivo in the absence of external stimulation, such as application of heat or antibiotics.…”

Section: Skin Devices Based On the Electrical Features Of The Skinmentioning

confidence: 99%

Electrical aspects of skin as a pathway to engineering skin devices

Abe

Nishizawa

2021

APL Bioengineering

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Skin is one of the indispensable organs for life. The epidermis at the outermost surface provides a permeability barrier to infectious agents, chemicals, and excessive loss of water, while the dermis and subcutaneous tissue mechanically support the structure of the skin and appendages, including hairs and secretory glands. The integrity of the integumentary system is a key for general health, and many techniques have been developed to measure and control this protective function. In contrast, the effective skin barrier is the major obstacle for transdermal delivery and detection. Changes in the electrical properties of skin, such as impedance and ionic activity, is a practical indicator that reflects the structures and functions of the skin. For example, the impedance that reflects the hydration of the skin is measured for quantitative assessment in skincare, and the current generated across a wound is used for the evaluation and control of wound healing. Furthermore, the electrically charged structure of the skin enables transdermal drug delivery and chemical extraction. This paper provides an overview of the electrical aspects of the skin and summarizes current advances in the development of devices based on these features.

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<p>Poly (lactic-co-glycolic acid)/graphene oxide composites combined with electrical stimulation in wound healing: preparation and characterization</p>

Cited by 28 publications

References 63 publications

Mussel-Inspired Gold Nanoparticle and PLGA/L-Lysine-g-Graphene Oxide Composite Scaffolds for Bone Defect Repair

Mussel-Inspired Gold Nanoparticle and PLGA/L-Lysine-g-Graphene Oxide Composite Scaffolds for Bone Defect Repair

Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives

Electrical aspects of skin as a pathway to engineering skin devices

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