&lt;p&gt;Predicting Individual Prognosis and Grade of Patients with Glioma Based on Preoperative Eosinophil and Neutrophil-to-Lymphocyte Ratio&lt;/p&gt;

Zhang, Xu; Li, Can; Xiao, Lifei; Gao, Caibin; Zhao, Wei; Yang, Maolin; Sun, Tao; Wang, Feng

doi:10.2147/cmar.s260695

Cited by 12 publications

(12 citation statements)

References 38 publications

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“…There are also some significant progress in the basic research, and comprehensive therapy of glioma has been made in recent years. However, the prognosis of patients with glioma has not been significantly improved as glioma induces an immune infiltrating environment [5,6]. In general, poor glioma prognosis shows a high rate of recurrence after treatment [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] A Prognostic Model for Brain Glioma Patients Based on 9 Signature Glycolytic Genes

Xiao

et al. 2021

BioMed Research International

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Objective. To screen glycolytic genes linked to the glioma prognosis and construct the prognostic model. Methods. The relevant data of glioma were downloaded from TCGA and GTEx databases. GSEA of glycolysis-related pathways was carried out, and enriched differential genes were extracted. Screening out prognostic-related genes with conspicuous significance and construction of the prognostic model were conducted by multivariate Cox regression analysis and Lasso regression analysis. The model was evaluated, and cBioPortal was used to analyze the mutation of the model gene. The expression of the model gene in tumor and normal colon tissue was analyzed. The model was used to evaluate the prognosis of patients in different groups to verify the applicability of the model. Results. 339 differentially glycolytic-related genes were enriched in REACTOME_GLYCOLYSIS, GLYCOLYTIC_PROCESS, HALLMARK_GLYCOLYSIS, and other pathways. We obtained 9 key prognostic genes and constructed the prognostic evaluation model. The 3-year AUC values of the ROC curve display model are greater than 0.75, which indicates that the accuracy of the model is good. The relation of age and risk score to prognosis is shown by univariate and multivariate Cox analysis. The expression of SRD5A3, MDH2, and B3GAT3 genes was significantly upregulated in the tumor tissues, while the HDAC4 and G6PC2 genes were downregulated. The mutation rate of MDH2 and HDAC4 genes was the highest. This model could effectively distinguish the risk of poor prognosis of patients in any age stage. Conclusion. The prognostic assessment models based on glycolysis-related nine-gene signature could accurately predict the prognosis of patients with GBM.

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Section: Introductionmentioning

confidence: 99%

[Retracted] A Prognostic Model for Brain Glioma Patients Based on 9 Signature Glycolytic Genes

Xiao

et al. 2021

BioMed Research International

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“…Relevant to this statement, empirically, remarkably fully 13 independent studies just between 2018 and 2020 reported the same findings-that a higher neutrophil to lymphocyte ratio-a relative or absolute neutrophilia-correlated with shorter survival in GB [66][67][68][69][70][71][72][73][74][75][76][77][78]. Few parameters in any cancer have been so oft confirmed.…”

Section: Dapsone Gb and Neutrophilsmentioning

confidence: 85%

Research Supporting a Pilot Study of Metronomic Dapsone during Glioblastoma Chemoirradiation

Kast¹

2021

Medical Sciences

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This short note presents previous research data supporting a pilot study of metronomic dapsone during the entire course of glioblastoma treatment. The reviewed data indicate that neutrophils are an integral part of human glioblastoma pathophysiology, contributing to or facilitating glioblastoma growth and treatment resistance. Neutrophils collect within glioblastoma by chemotaxis along several chemokine/cytokine gradients, prominently among which is interleukin-8. Old data from dermatology research has shown that the old and inexpensive generic drug dapsone inhibits neutrophils’ chemotaxis along interleukin-8 gradients. It is on that basis that dapsone is used to treat neutrophilic dermatoses, for example, dermatitis herpetiformis, bullous pemphigoid, erlotinib-related rash, and others. The hypothesis of this paper is that dapsone will reduce glioblastomas’ neutrophil accumulations by the same mechanisms by which it reduces dermal neutrophil accumulations in the neutrophilic dermatoses. Dapsone would thereby reduce neutrophils’ contributions to glioblastoma growth. Dapsone is not an ideal drug, however. It generates methemoglobinemia that occasionally is symptomatic. This generation is reduced by concomitant use of the antacid drug cimetidine. Given the uniform lethality of glioblastoma as of 2020, the risks of dapsone 100 mg twice daily and cimetidine 400 mg twice daily is low enough to warrant a judicious pilot study.

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“…The incidence of LGG is increasing worldwide (Zhang et al, 2020). LGG patients have a relatively favorable prognosis.…”

Section: Discussionmentioning

confidence: 99%

CRISPR-cas9 Screening Identified Lethal Genes Enriched in Hippo Kinase Pathway and of Prognosis Significance in primary Low-grade Glioma

Mijiti

Maimaiti

Chen

et al. 2022

Preprint

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Background Lethal genes in low-grade gliomas (LGGs) may have an essential prognostic significance and therefore need to be systematically analyzed. The purpose of this study is to analyze essential genes correlated with cell survival by evaluating CRISPR-cas9 screening data, leading to the identification of novel treatment targets for patients. Methods In this study, genes related to cell viability from the Depmap CRISPR-cas9 screen were intersected to differentially expressed genes (DEGs) between tumor and GTEx normal tissues from TCGA. The LASSO regression method was used to construct a signature that used to anticipate overall survival in patients with LGG. An evaluation of the signature was carried out using both multivariate and univariate Cox regression. Then, we determined which key pathways were modulated by this signature by comparing DEGs between low- and high-risk patients. WGCNA was conducted to identify modules associated with high-risk. In this study, we also performed enrichment analysis to identify pathways mediated by DEGs, overlapping genes, and genes shared in the WGCNA. Finally, we used to western blot, qRT-PCR and IHC to detect the expression of hub genes. Results Using the TCGA database, 145 oncogenes were identified as overexpressed. These genes were intersected with lethal genes identified in the Depmap database, which are enriched in Hippo pathways. A total of 19 genes were used to construct the gene signature by means of LASSO regression. The median risk score (0.752324) was employed to distinguish between low- and high-risk patients. The patients with high-risk characteristics showed a shorter OS duration in the internal training, the internal validation, and the external validation datasets. Ultimately, the Hippo signaling pathway was the predominantly enriched pathway in 145 genes, DEGs, and 3 modular genes in WGCNA. Finally, we found differences of hub genes expression in different clinical samples. Importantly, protein and mRNA expression of REP65 was significantly up-regulated in tumor cells both in the public cohort and our cohort. Conclusion The hippo signaling pathway detected based on CRISPR-cas9 screening is a critical regulator of viability and tumor proliferation and therefore is an innovative new target for treating cancerous brain tumors, including LGG.

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<p>Predicting Individual Prognosis and Grade of Patients with Glioma Based on Preoperative Eosinophil and Neutrophil-to-Lymphocyte Ratio</p>

Cited by 12 publications

References 38 publications

[Retracted] A Prognostic Model for Brain Glioma Patients Based on 9 Signature Glycolytic Genes

[Retracted] A Prognostic Model for Brain Glioma Patients Based on 9 Signature Glycolytic Genes

Research Supporting a Pilot Study of Metronomic Dapsone during Glioblastoma Chemoirradiation

CRISPR-cas9 Screening Identified Lethal Genes Enriched in Hippo Kinase Pathway and of Prognosis Significance in primary Low-grade Glioma

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