<p>Relationship between abnormal glucose metabolism and osteoporosis in Han Chinese men over the age of 50 years</p>

Abstract

Aim The aim of this study was to determine the relationship between abnormal glucose metabolism and osteoporosis (OP) in Han Chinese men over the age of 50 years. Patients and methods A cross-sectional study of 775 male patients aged over 50 years was performed at our hospital in 2011. The patients were divided into a normal glucose metabolism group, an impaired glucose regulation (IGR) group, and a type 2 diabetes mellitus (T2DM) group. Differences in their bone mineral densities (BMDs), OP detection rates, and indices of bone metabolism were assessed. Results After adjusting for age and body mass index (BMI), there were no significant differences in lumbar spine, femoral neck, and total hip BMD values in the three groups ( P >0.05) nor in OP detection rates ( P =0.19). However, there were some significant differences in bone metabolism markers between the groups after adjusting for age, BMI, and serum creatinine (Cr): 25-hydroxyvitamin D (25(OH)D) was positively correlated with the presence of abnormal glycometabolism ( r =0.08; P <0.01), while β-carboxy-terminal cross-linking telopeptide of type I collagen (β-CTX), bone gamma-carboxyglutamic acid protein (BGP; osteocalcin [OC]), and procollagen type 1 intact N-terminal propeptide (P1NP) were negatively correlated ( r =−0.13, −0.21, −0.14, respectively; P <0.01). Logistic regression analysis of the data indicated that BGP was the only bone metabolism marker significantly influenced by abnormal glucose metabolism (OR =0.96). Conclusion There were no significant differences in BMD or OP detection rates between the three glycometabolism groups after adjusting for age and BMI. However, the bone metabolism marker, BGP, was significantly negatively correlated with abnormal glucose metabolism.

Assessment of Risk Factors for Fractures in Patients with Type 2 Diabetes over 60 Years Old: A Cross-Sectional Study from Northeast China

“…BMD is measured to assess osteoporosis in many medical institutions. Although previous studies have reported that the BMD of patients with T2DM was normal or even higher than that of nondiabetic controls, the fracture risk was higher in patients with T2DM [4,26]. Our study also showed that the BMD levels between T2DM and non-T2DM patients were similar (p = 0:131), although the T2DM population had a higher risk for fractures (OR 1.357).…”

<p>Relationship of Two-Hour Plasma Glucose and Abdominal Visceral Fat with Bone Mineral Density and Bone Mineral Content in Women with Different Glucose Metabolism Status</p>

“…6 However, there was a study showed the detection rates of low BMD and osteoporosis have no significant differences among different glucose metabolism groups. 7 Meta-analysis results also indicated that abnormal glucose metabolism showed no significant correlation with BMD or bone metabolism. 8 The effect of obesity on BMD is associated with varied factors, but the relationship between obesity and osteoporosis still remains to be controversial, 9 and it is inconclusive whether obesity increases or decreases BMD.…”

miR‑205 regulates bone turnover in elderly female patients with type 2 diabetes mellitus through targeted inhibition of Runx2

“…The ovarian function and estrogen level continuously decline in women relative to age, ultimately leading to osteoporosis (OP) ( 1 ). OP is one of the common complications of patients with type 2 diabetes mellitus (T2DM), causing great morbidity and seriously affecting the quality of life of patients ( 2-4 ). Currently, the main therapeutic methods for elderly patients with T2DM and OP include calcium and vitamin D supplements, physical exercise, specified diet and high quality nursing, yet the occurrence and progression of OP in elderly patients with T2DM cannot be effectively controlled ( 5 , 6 ).…”