&lt;p&gt;Serum β2-Microglobulin is Associated with Mortality in Hospitalized Patients with Exacerbated Chronic Obstructive Pulmonary Disease&lt;/p&gt;

Mao, Wenping; Wang, Jing; Li-ming, Zhang; Wang, Ying; Wang, Wenjun; Zeng, Na; Zhang, Jun; Li, Qian; Jiao, Fengwei; Li, Jie; Cui, Na; Mi, Shuhua; Xue, Yi; Wang, Zhaomei; Ying, Sun; Huang, Kewu

doi:10.2147/copd.s243905

Cited by 7 publications

(7 citation statements)

References 41 publications

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“…[48] Previous studies also reported the relationship between B2M and diseases related to immunity and inflammation. [10,49,50] B2M was also found to trigger an inflammatory process in vivo. [51] However, the influences of hypertension on mortality are unlikely to be dominated by the same pathways as for B2M.…”

Section: Discussionmentioning

confidence: 99%

Association of beta-2-microglobulin with cardiovascular and all-cause mortality in the general and non-CKD population

2023

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β-2 microglobulin, a light chain in the major histocompatibility complex Class 1 molecule, is associated with mortality in dialysis or uremic patients. Current evidence on the relationship between beta-2-microglobulin (B2M) and mortality in the general and non-chronic kidney disease (CKD) population are limited and controversial. Data from the nutrition and health examination survey database and the nutrition and health examination survey linked mortality file were used. In total, 10,388 adults who had complete data for B2M were included. Weighted multivariable Cox proportional hazards regression models and regression splines were employed to evaluate the relationship between B2M with mortality. Moreover, subgroup and sensitivity analyses were performed. During a median follow up of 17.9 years (interquartile range 15.2–18.7), 2780 people died, 902 (32%) from cardiovascular disease. Restricted cubic splines showed that B2M is J-shaped nonlinear positively associated with all-cause mortality and cardiovascular disease mortality in the non-CKD and general population. Based on the multivariable adjustment model, the adjusted hazard ratios comparing the highest versus lowest quartile of the distribution of B2M were 2.50 (95% confidence interval: 1.90, 3.28) for all-cause mortality in the general population, 2.58 (95% confidence interval: 1.52, 4.37) for cardiovascular disease mortality in the general population, 2.58 (1.91, 3.49) for all-cause mortality in the non-CKD population and 2.62 (1.52, 4.53) for cardiovascular disease mortality in the non-CKD population. The positive associations between B2M and outcomes remained broadly significant across subgroups and sensitivity analyses. Higher B2M levels were associated with cardiovascular and all-cause mortality in the general and non-CKD population.

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Section: Discussionmentioning

confidence: 99%

Association of beta-2-microglobulin with cardiovascular and all-cause mortality in the general and non-CKD population

2023

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“…The level of serum β2MG depends on the factors of production (non-kidney factors) and elimination (kidney factors). Due to these properties, β2MG is not only an ideal endogenous biomarker for estimating the glomerular ltration rate and AKI [6-9] and the adverse outcomes of chronic kidney disease [23], but also associated with a number of clinical states beyond kidney disease [11][12][13][14][15][16]. Several previous studies have shown that levels of serum β2MG are higher in patients with in ammatory bowel disease or systemic lupus erythematosus than in healthy controls, suggesting that it might also be a useful biomarker for the assessment of these autoimmune diseases [16,24].…”

Section: Discussionmentioning

confidence: 99%

“…Levels of serum β2MG are independently associated with major cardiovascular events and mortality in the general population as well as in elderly patients and in patients with acute heart failure who do not have severe renal insu ciency [13,15,29]. Studies have shown that serum β2MG levels are also associated with poor outcomes in patients with COPD and in patients with acute pulmonary embolism [12,14].…”

Section: Discussionmentioning

confidence: 99%

“…These properties may make it an ideal endogenous biomarker for estimating the glomerular ltration rate and acute kidney injury (AKI) [6][7][8][9]. Numerous studies have shown that the serum β2MG level is not only used in assessing renal function by estimating the glomerular ltration rate and monitoring the effects of Page 3/24 treatment [10] but also associated with a number of clinical states, including chronic in ammatory diseases, malignancies, and adverse outcomes in chronic obstructive pulmonary disease (COPD), acute pulmonary embolism, and cardiovascular diseases even though patients with preserved renal function [11][12][13][14][15][16]. ARDS is accompanied by an overwhelming in ammatory response and severe organ dysfunction, especially AKI.…”

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confidence: 99%

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Serum β2‑microglobulin: An independent risk factor for mortality in patients with acute respiratory distress syndrome caused by bacterial infection

Li-ming

Cui

Feng

et al. 2022

Preprint

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Background: Acute respiratory distress syndrome (ARDS) is a heterogeneous disease with extremely high mortality. We hypothesized that the serum β2-microglobulin (β2MG) level would be elevated and be an independent risk factor for 28-day mortality in patients with ARDS caused by bacterial infection. Methods: We retrospectively enrolled 257 patients with ARDS caused by bacterial infection from January 1, 2015 to February 28, 2021. Patients were followed for up to 28 days and were divided into a survival group and non-survival group according to their clinical outcomes. The serum β2MG levels and other clinical data were collected. The relationship between β2MG levels and 28-day mortality was explored by performing a Cox regression analysis adjusted for age, updated Charlson comorbidity index, disorders of consciousness, septic shock, albumin level, cardiac troponin I level, procalcitonin level, lactic acid level, prothrombin time, partial pressure of arterial oxygen/fraction of inspired oxygen ratio, creatinine clearance rate, acute kidney injury and Sequential Organ Failure Assessment.Results: In this cohort, 96 patients died in 28 days, yielding a 28-day mortality of 37.4%. The median level of serum β2MG for all enrolled patients was 4.7 (interquartile range [IQR]:2.9 - 8.5) mg/L. Higher β2MG levels were significantly associated with 28-day mortality when the β2MG level was analysed as a continuous variable (hazard ratio [HR]: 1.054; 95% confidence interval [CI]:1.005 - 1.105; P = 0.031) and when it was categorized into tertiles (HR: 3.239; 95% CI: 1.177 - 8.913; P = 0.023). The β2MG level exhibited a high diagnostic accuracy for predicting 28-day mortality (area under the curve [AUC] = 0.732; 95% CI:0.673-0.785; sensitivity:74.0%; specificity:64.0%; P<0.001). Conclusions: The level of serum β2MG is elevated and is an independent risk factor of 28-day mortality in patients with ARDS caused by bacterial infection.

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“…There are many reports about the relationship between β2M and peripheral organ diseases (including tumors) related to immunity and inflammation (Wilson et al, 2007;Josson et al, 2011;Hermansen et al, 2012;Mao et al, 2020), and the central nervous system (CNS) has traditionally been regarded as immune-privileged, though this has been questioned (Piehl and Lidman, 2001). The mechanism of β2M and poststroke immunity and inflammation may be complex, and there are relatively few reports.…”

Section: Introductionmentioning

confidence: 99%

β2-Microglobulin is a Novel and Reliable Biomarker for Predicting Ischemic Stroke Recurrence: A Prospective Cohort Study

Liu

et al. 2022

Front. Pharmacol.

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Immune and inflammatory mechanisms play key roles in the development and outcome of acute ischemic stroke (AIS). β2-Microglobulin (β2M) is the light chain of major histocompatibility complex-1 (MHC-1), which can directly and quickly reflect the immune and inflammatory state of the body. Previous studies have shown a close relationship between β2M and AIS, but its relationship with the recurrence of AIS has not been reported. This study attempted to explore the relationship between β2M and the recurrence of AIS. A single-center AIS cohort involving 135 patients was followed for approximately 26–46 months. Clinical and laboratory data from the patients were collected when hospitalized. The endpoint was the occurrence of recurrent AIS after patients were discharged. Propensity score matching was used to match cohort groups. Cox regression analysis was used to predict risk factors for recurrent AIS, and receiver operating characteristic curve (ROC) analysis was used to calculate the optimal cutoff value for discriminating recurrence in patients with AIS. The rate of recurrence was 29.6% [95% CI, 21.8%–37.3%] in the follow-up group. Patients with higher levels of serum β2M had a higher risk of AIS recurrence than patients with lower levels of β2M (adjusted hazard ratio, 3.214 [95% CI, 1.557–6.633]; adjusted hazard ratio after matching, 5.831, [95% CI, 2.052–16.572]). A β2M value of 2.31 mg/L was calculated by ROC analysis as the optimal cutoff value for AIS recurrence (area under the curve 0.770, [95% CI, 0.687–0.853]). As a quick responder to the body’s immune and inflammatory states, β2M may be a novel and reliable biomarker in predicting AIS recurrence.

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<p>Serum β2-Microglobulin is Associated with Mortality in Hospitalized Patients with Exacerbated Chronic Obstructive Pulmonary Disease</p>

Cited by 7 publications

References 41 publications

Association of beta-2-microglobulin with cardiovascular and all-cause mortality in the general and non-CKD population

Association of beta-2-microglobulin with cardiovascular and all-cause mortality in the general and non-CKD population

Serum β2‑microglobulin: An independent risk factor for mortality in patients with acute respiratory distress syndrome caused by bacterial infection

β2-Microglobulin is a Novel and Reliable Biomarker for Predicting Ischemic Stroke Recurrence: A Prospective Cohort Study

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