<p>Stability and Compatibility of Ramosetron with Midazolam in 0.9% Sodium Chloride Injection for Postoperative Nausea and Vomiting Administration</p>

Abstract

Background: Combination antiemetic therapy has become a common practice for the prevention of postoperative nausea and vomiting (PONV). The aim of the present study was to evaluate the stability and compatibility of ramosetron hydrochloride and midazolam in 0.9% sodium chloride injection when stored at 4°C and 25°C for up to 14 days. Methods: Admixtures were assessed initially and for 14 days after preparation in polyolefin bags and glass bottles using 0.9% sodium chloride injection as the diluent and stored at 4°C or 25°C. The initial concentrations were 0.3 mg/100 mL ramosetron hydrochloride and 0.5 mg/ 100 mL midazolam hydrochloride. For all samples, the compatibility parameters (including precipitation, cloudiness, discoloration and pH values) were evaluated. Chemical stability was also determined using high-performance liquid chromatography (HPLC) analysis. Results: After a 14-day period of storage at 4°C or 25°C, the percent of the initial concentration of ramosetron hydrochloride and midazolam hydrochloride in the various solutions were maintained at a minimum of 97%. All of the mixtures remained clear and colourless throughout the observation period, and no colour change or precipitation was observed. Conclusion:The results indicate that admixtures of 0.3 mg/100 mL ramosetron hydrochloride and 0.5 mg/100 mL midazolam hydrochloride in normal saline were stable for 14 days at 4°C or 25°C when packaged in polyolefin bags or glass bottles and protected from light.

Physical compatibility and chemical stability of dezocine and ramosetron in 0.9% sodium chloride injection for patient-controlled analgesia administration

“…[21] Moreover, Xia et al reported that the mixture solution of 0.3 mg/100 mL ramosetron hydrochloride and 0.5 mg/100 mL midazolam hydrochloride was stable at room temperature or under refrigeration for 14 days. [22] He et al discovered that 100 and 200 μg/mL dexamethasone with 3.0 μg/mL ramosetron hydrochloride were physical compatible and chemical stable for up to 2 days in 5% glucose injection or NS injection in non-PVC infusion bags at 25°C. [23] In this study, the analytical methods for dezocine and ramosetron hydrochloride were based on the preliminary studies.…”

“…[23] In this study, the analytical methods for dezocine and ramosetron hydrochloride were based on the preliminary studies. [20,22] The HPLC assay results revealed that the percentages of the concentration of dezocine and ramosetron for subsequent samples to the corresponding initial concentration were both > 96%. Throughout the study period, no color change or precipitation was observed in either PVC bags or glass bottles in any batch of samples.…”

Compatibility and stability of methylprednisolone sodium succinate and granisetron hydrochloride in 0.9% sodium chloride solution

“…[ 10 ] In detail, testing solutions was degraded with 0.1 mol/L sodium hydroxide (acidified), 0.1 mol/L sodium hydroxide (alkaline degraded), and 3% hydrogen peroxide (oxidized) for 5 hours at 60°C. [ 8 , 12 ] The chromatogram from the degraded solution was obtained and then evaluation of drug concentrations by HPLC assay has been performed for all samples.…”

“…[7] Hence, facilitating the acquisition and use of stability and compatibility-related information on these mixtures are required to ensure safety and feasibility of such a practice. [8,9] From the literature survey, stability and compatibility of MSS and GH have been investigated already, [10,11] but the information was limited. Therefore, to provide background information on the storage of a binary admixture of MSS with GH, the purpose of this study was to measure the stability of MSS-GH solutions at different concentration combinations, which were prepared in 0.9% sodium chloride and stored for a period of up to 72 hours at 4°C and 25°C.…”

“…[ 7 ] Hence, facilitating the acquisition and use of stability and compatibility-related information on these mixtures are required to ensure safety and feasibility of such a practice. [ 8 , 9 ]…”