&lt;p&gt;Successful Treatment of Peripheral Proliferative Vitreoretinopathy with Cryocoagulation During Retinal Detachment Repair – A New Surgical Technique&lt;/p&gt;

Guber, Josef; Lang, Corina; Scholl, Hendrik P. N.; Guber, Ivo; Valmaggia, Christophe

doi:10.2147/opth.s249881

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Başvurucunun dd asına göre yen eve taşınma sebeb , öncek da rede asansör ve benzer g b engell çocuğunun ht yaçlarına karşılık verecek olanakların bulunmamasıdır. 115 Baş vurucunun ulusal mevzuatta yer alan, aile ihtiyaç ları iç in ev satış ında geç erli olan vergi muafi yeti dü zenlemesinden yararlanma talebi reddedilmiş tir. Yerel mahkemelere yaptığı başvurulardan sonuç alamayan Guberina, ayrımcılık yasağının ihlal edildiği iddiasıyla Hırvat Anayasa Mahkemesine müracaat etmiştir.…”

Section: Glor / İsviçre Kararı (30 Nisan 2009) 73unclassified

“…116 AİHM, Birleşmiş Milletler Engelli Hakları Sözleşmesinin çocuklara yönelik engellilik temelinde ayrımcılık yasağı, bireysel özerklik ve erişilebilirlik hakkı gibi ayrımcılık yasağı unsurlarının düzenlendiği çeşitli kaynaklar bakımından değerlendirme yapmıştır. 117 Mahkeme, Ayrıca Birleşmiş Milletler Engelli Birey Hakları Komitesi'nin, 118 Birleşmiş Milletler Ekonomik Sosyal ve Kültürel Haklar Komitesi'nin, 119 Avrupa Konseyi Bakanlar Komitesi'nin çeşitli kararlarına 120 ve Avrupa Birliği Temel Haklar Şartı'nın 21. ve 26. maddelerine de gönderme yapmıştır. 121 Bu doğrultuda AİHM benzer statü kavramına girdiğ ini değ erlendirdiğ i uyuşmazlıkta, baş vuruyu mü lkiyet hakkı bağ lamında ayrımcılık yasağ ı ç erç evesinde incelemiş tir.…”

Section: Glor / İsviçre Kararı (30 Nisan 2009) 73unclassified

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Ayrimcilik Yasaği Bağlaminda Engelli̇ Bi̇reyleri̇n Haklarina İli̇şki̇n Avrupa İnsan Haklari Mahkemesi̇ Kararlari

Duvan¹

2019

Ankara Hacı Bayram Veli Üniversitesi Hukuk Fakültesi Dergisi

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ÖZAvrupa İnsan Hakları Sözleşmesi "engelli" terimini içermemesine karşın, eşitlik hakkı ve ayrımcılık yasağını düzenleyen hükümleriyle engelli bireyler için önemli güvenceler sağlamaktadır. Avrupa İnsan Hakları Mahkemesinin engelli birey haklarına yönelik yaklaşımı 14. maddedeki düzenleme ve ayrımcılık yasağını genelleştiren 12. Protokol'le sınırlı değildir. Engelli bireylere ilişkin uyuşmazlıklarda yaşam hakkı, özgürlük ve güvenlik hakkı, adil yargılanma hakkı, evlenme hakkı, seçme hakkı, özel yaşama saygı hakkı, mülkiyet hakkı, eğitim hakkı ve kötü muamele yasağı gibi haklar da bazen ayrımcılık yasağı bağlamında, bazen de ayrımcılık yasağından bağımsız olarak değerlendirilmiştir. Mahkemenin Poirrez/Fransa, Glor/İsviçre, Çam/Türkiye, Guberina/Hırvatistan ve Şahin/Türkiye kararlarında ise ayrımcılık yasağı ekseninde engelli bireylerin hakları koruma altına alınmıştır. Mahkeme bu içtihadında Birleşmiş Milletler Engelli Hakları Sözleşmesi gibi spesifik olarak engelli birey haklarını düzenleyen kaynaklara sıkça atıf yapmış, ulusal ve uluslararası hukuk düzleminde emsal teşkil eden kararlara imza atmıştır. ABSTRACT Although the European Convention on Human Rights does not include the term "disability" it provides important safeguards for individuals with disabilities with its provisions regulating the right to equality and non-discrimination. The EuropeanCourt of Human Rights' approach to the rights of persons with disabilities is not limited to Protocol 12, which generalizes the prohibition of regulation on non-discrimination in Article 14. Rights such as the right to life, the right to liberty and security, the right to a fair trial, the right to marry, the right to vote, the right to respect for private life, the right to protection of property, the right to education and the prohibition of torture for persons with disabilities are sometimes considered in the context of the non-* Dr. Öğr. Üyes , İstanbul Ün vers tes Hukuk Fakültes , Genel Kamu Hukuku Anab l m Dalı Öğret m Üyes ,

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Section: Glor / İsviçre Kararı (30 Nisan 2009) 73unclassified

Ayrimcilik Yasaği Bağlaminda Engelli̇ Bi̇reyleri̇n Haklarina İli̇şki̇n Avrupa İnsan Haklari Mahkemesi̇ Kararlari

Duvan¹

2019

Ankara Hacı Bayram Veli Üniversitesi Hukuk Fakültesi Dergisi

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“…The tracking force of the ERMs causes retinal detachment [8]. At present there is no approved medicine for this eye disease [9]; the only treatment option with the surgery leads to the poor sight recovery [10,11]. Therefore, it is urgent to develop a pharmacological approach for the therapy of PVR.…”

Section: Introductionmentioning

confidence: 99%

Ligand-independent Activation of Platelet-derived Growth Factor Receptor β promotes contraction of retinal pigment epithelial cells

Duan

Cui

et al. 2023

Preprint

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Background Epiretinal membranes in patients with proliferative vitreoretinopathy (PVR) consist of extracellular matrix and a number of cell types including retinal pigment epithelial (RPE) cells and fibroblasts, whose contraction causes retinal detachment. In RPE cells depletion of platelet-derived growth factor (PDGF) receptor (PDGFR)β suppresses vitreous-induced Akt activation, whereas in fibroblasts Akt activation through indirect activation of PDGFRα by growth factors outside the PDGF family (non-PDGFs) plays an essential role in experimental PVR. Whether non-PDGFs in the vitreous, however, were also able to activate PDGFRβ in RPE cells remained elusive. Methods We showed that expression of a truncated PDGFRβ lacking a PDGF-binding domain in the RPE cells whose PDGFRB gene had been silent using the CRISPR/Cas9 technology restored vitreous-induced Akt activation as well as cell proliferation, epithelial-mesenchymal transition, migration and contraction. Results We found that scavenging reactive oxygen species (ROS) with N-acetyl-cysteine and inhibiting Src family kinases (SFKs) with their specific inhibitor SU6656 blunted the vitreous-induced activation of the truncated PDGFRβ and Akt as well as the cellular events related to the PVR pathogenesis. Conclusions These discoveries suggest that in RPE cells PDGFRβ can be activated indirectly by non-PDGFs in the vitreous via an intracellular pathway of ROS/SFKs to facilitate the development of PVR, thereby providing novel opportunities for PVR therapeutics.

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Section: Introductionmentioning

confidence: 99%

Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β Promotes Contraction of Retinal Pigment Epithelial Cells

et al. 2023

austinjclinopthalmol

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Background: Epiretinal membranes in patients with Proliferative Vitreoretinopathy (PVR) consist of extracellular matrix and a number of cell types including Retinal Pigment Epithelial (RPE) cells and fibroblasts, whose contraction causes retinal detachment. In RPE cells depletion of Platelet-Derived Growth Factor (PDGF) receptor (PDGFR) β suppresses vitreous-induced Akt activation, where as in fibroblasts Akt activation through indirect activation of PDGFRa by growth factors outside the PDGF family (non-PDGFs) plays an essential role in experimental PVR. Whether non-PDGFs in the vitreous, however, were also able to activate PDGFRβ in RPE cells remained elusive. Methods: We showed that expression of a truncated PDGFRβ lacking a PDGF-binding domain in the RPE cells whose PDGFRB gene had been silent using the CRISPR/Cas9 technology restored vitreous-induced Akt activation as well as cell proliferation, epithelial-mesenchymal transition, migration and contraction. Results: We found that scavenging Reactive Oxygen Species (ROS) with N-acetyl-cysteine and inhibiting Src Family Kinases (SFKs) with their specific inhibitor SU6656 blunted the vitreous-induced activation of the truncated PDGFRβ and Akt as well as the cellular events related to the PVR pathogenesis. Conclusions: These discoveries suggest that in RPE cells PDGFRβ can be activated indirectly by non-PDGFs in the vitreous via an intracellular pathway of ROS/SFKs to facilitate the development of PVR, thereby providing novel opportunities for PVR therapeutics.

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<p>Successful Treatment of Peripheral Proliferative Vitreoretinopathy with Cryocoagulation During Retinal Detachment Repair – A New Surgical Technique</p>

Cited by 5 publications

References 6 publications

Ayrimcilik Yasaği Bağlaminda Engelli̇ Bi̇reyleri̇n Haklarina İli̇şki̇n Avrupa İnsan Haklari Mahkemesi̇ Kararlari

Ayrimcilik Yasaği Bağlaminda Engelli̇ Bi̇reyleri̇n Haklarina İli̇şki̇n Avrupa İnsan Haklari Mahkemesi̇ Kararlari

Ligand-independent Activation of Platelet-derived Growth Factor Receptor β promotes contraction of retinal pigment epithelial cells

Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β Promotes Contraction of Retinal Pigment Epithelial Cells

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