<p>Synthesis, Characterization and DNA Binding Investigations of a New Binuclear Ag(I) Complex and Evaluation of Its Anticancer Property</p>

Abstract

A new Ag(I) complex (A 3) was synthesized and evaluated for its anticancer activity against human cancer cell lines. Materials and Methods: The complex A 3 was characterized by 1 H, 13 C, and 31 P nuclear magnetic resonance (NMR), infrared (IR) spectra, elemental analysis, and X-ray crystallography. The interaction of the complex with CT-DNA was studied by electronic absorption spectra, fluorescence spectroscopy, and cyclic voltammetry; cell viability (%) was assessed by absorbance measurement of the samples. Results: The interaction mode of the complex A 3 with DNA is electrostatic, and this complex shows good potential in anticancer properties against HCT 116 (human colorectal cancer cells) and MDA-MB-231 (MD Anderson-metastatic breast) cell lines with 0.5 micromolar concentrations. Conclusion: The Ag(I) complex could interact with DNA noncovalently and has anticancer properties.

Silver Complexes as Anticancer Agents: A Perspective Review

“…The anticancer activity of binuclear Ag (I)-triphenylphosphine complex [(pph3)3Ag(L1)] and [(pph3)3Ag(L1)](A3) against HCT116 and MDA-MB-231 cell lines were demonstrated using cell counting kit-8 (CCK-8) assay. This A3 complex expressed more significant anti-proliferation activity against all cancer cell lines [6]. The cytotoxicity of Ag (I)-5,5-diethyl barbiturate-bis(diphenyl phospino) alkane complexes 27-30 against MCF-7, A549, PC-3, HT29 cancer cell lines and MCF 10A (non-cancer) cell lines were determined using SRB assay.…”

“…Metal complexes with unique characteristics, including reactivity, different coordination routes and redox ability, showed tremendous potential in cancer therapy. These complexes showed a better cytotoxic action than the ligands through reactive oxygen species (ROS) production, cell membrane alteration, inhibiting DNA replication, affecting electron transport and perturbation of enzyme action and altering redox potential of the cell [2][3][4][5][6].…”

Two new Cu (II) complexes based on 5‐fluorouracil‐1‐yl acetic acid and N‐donor ligands: Investigation of their interaction with DNA and anticancer activity

“…The antitumor efficiency of the 5-Fu molecules can be increased with some solutions such as the substitution of them by some functional groups or use of them along with the other compounds. [34,35] In this work, the synthesis and characterization of two Cu complexes, [Cu (bpy) 2 L1] BF 4 .CH 3 OH (Z 3 ) and [Cu (phen) 2 L1] BF 4 ÁH 2 O (Z9), L1 = 5-Fluorouracil-1-yl Acetic Acid, have been described and their interaction with CT-DNA and also, the anticancer activity of them against MDA-MB-231 (MD Anderson-Metastatic Breast) and HCT116 (human colorectal cancer cells) cancer cell lines have been investigated.…”