&lt;p&gt;The Antibiofilm Activity and Mechanism of Nanosilver- and Nanozinc-Incorporated Mesoporous Calcium-Silicate Nanoparticles&lt;/p&gt;

Leng, Diya; Li, Yan; Zhu, Jing; Liang, Ruizhen; Zhang, Cuifeng; Zhou, Yang; Li, Mingming; Wang, Ying; Rong, Di; Wu, Daming; Li, Jin

doi:10.2147/ijn.s244686

Cited by 50 publications

(48 citation statements)

References 38 publications

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“…Furthermore, different types of nanoparticles inhibit biofilm formation in various bacterial species. For example, in a study by Mohanta and co-workers, newly synthesized silver nanoparticles were reported to possess antibacterial and anti-biofilm activities against Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus [106]. Previous studies have also reported that mesoporous calciumsilicate nanoparticles possess antibacterial activity against Enterococcus faecalis biofilms in different degrees [107].…”

Section: Confocal Laser Scanning Microscopy (Clsm)mentioning

confidence: 99%

Biogenic ZnO Nanoparticles Synthesized from Origanum vulgare Abrogates Quorum Sensing and Biofilm Formation in Opportunistic Pathogen Chromobacterium violaceum

et al. 2021

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This study presents an inexpensive, eco-friendly, and simple green synthesis of ZnO nanoparticles using Origanum vulgare extract. These nanoparticles are non-hazardous, environmentally friendly, and cheaper than other methods of biosynthesis. Ongoing research determines the role of phytochemicals in the fabrication and biosynthesis of ZnO NPs and their role in antibacterial activity and biomedical applications. Characterizations by fourier transform infrared spectroscopy (FTIR), diffuse reflectance UV-visible spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) determine the successful biosynthesis of ZnO NPs. Meanwhile, TEM and X-ray diffraction studies approximated the spherical morphology and crystalline nature of biosynthesized ZnO NPs of nano size in the range of 20–30 nm. The global increase in drug resistance necessitates the search for new drugs with different mechanisms of action. Quorum sensing (QS), a cell-to-cell communication, has gained attention as an emerging drug target. It controls numerous biochemical processes in bacteria, which are essential for their survival and pathogenicity. The potential of nanomedicines has also been tested to synthesize new antibiotics to tackle drug resistance. ZnO NPs were explored for their antibacterial, antiquorum sensing, and antibiofilm activities with a bioreporter strain of Chromobacterium violaceum. Susceptibility testing results indicated the potential antibacterial activity of ZnO NPs with a minimum inhibitory concentration (MIC) of 4 µg/mL and minimum bactericidal concentration (MBC) of 16 µg/mL. Antiquorum-sensing assays revealed that these nanoparticles inhibit quorum sensing with minimum antiquorum sensing activity (MQSIC) of 1 µg/mL, without causing any bacterial growth inhibition. In addition, ZnO NPs inhibit biofilm formation at inhibitory and higher concentrations. RT-qPCR results supported the downregulation of the quorum sensing genes when C. violaceum was treated with ZnO NPs. The outcomes of this study are promising with regard to the biofilm and quorum sensing, emphasizing the potential applications of ZnO NPs against bacterial communication and biofilm formation.

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Section: Confocal Laser Scanning Microscopy (Clsm)mentioning

confidence: 99%

Biogenic ZnO Nanoparticles Synthesized from Origanum vulgare Abrogates Quorum Sensing and Biofilm Formation in Opportunistic Pathogen Chromobacterium violaceum

et al. 2021

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“…Mesoporous calcium silicate nanoparticles combined with silver nanoparticles were able to inhibit the growth of both planktonic and biofilm forms of E. faecalis [ 209 , 210 ]. Studies have also suggested their applicability as novel root canal sealers due to their bioactive and osteogenic properties [ 211 – 214 ]. Other nanoparticles with sustained antibiofilm activity that have been explored as root canal sealers include quaternary ammonium polyethyleneimine [ 215 ] and quaternary ammonium methacrylate nanoparticles [ 216 ].…”

Section: Clinical Implications Of Root Canal Infectionsmentioning

confidence: 99%

Microbiological Aspects of Root Canal Infections and Disinfection Strategies: An Update Review on the Current Knowledge and Challenges

Wong

Manoil

Näsman

et al. 2021

Front. Oral. Health

114

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The oral cavity is the habitat of several hundreds of microbial taxa that have evolved to coexist in multispecies communities in this unique ecosystem. By contrast, the internal tissue of the tooth, i.e., the dental pulp, is a physiologically sterile connective tissue in which any microbial invasion is a pathological sign. It results in inflammation of the pulp tissue and eventually to pulp death and spread of inflammation/infection to the periradicular tissues. Over the past few decades, substantial emphasis has been placed on understanding the pathobiology of root canal infections, including the microbial composition, biofilm biology and host responses to infections. To develop clinically effective treatment regimens as well as preventive therapies, such extensive understanding is necessary. Rather surprisingly, despite the definitive realization that root canal infections are biofilm mediated, clinical strategies have been focused more on preparing canals to radiographically impeccable levels, while much is left desired on the debridement of these complex root canal systems. Hence, solely focusing on “canal shaping” largely misses the point of endodontic treatment as the current understanding of the microbial aetiopathogenesis of apical periodontitis calls for the emphasis to be placed on “canal cleaning” and chemo-mechanical disinfection. In this review, we dissect in great detail, the current knowledge on the root canal microbiome, both in terms of its composition and functional characteristics. We also describe the challenges in root canal disinfection and the novel strategies that attempt to address this challenge. Finally, we provide some critical pointers for areas of future research, which will serve as an important area for consideration in Frontiers in Oral Health.

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“… 118 With the addition of AgNPs, mesoporous calcium silicate nanoparticles showed sustained release of Ag ions and inhibited E. faecalis colonization. 119 , 120 Other studies found the combination of AgNPs and nano-zinc with mesoporous calcium silicate nanoparticles exhibited good antibiofilm efficacy, minimal cytotoxicity, 121 sustained ion release, dentinal tubule infiltration and negligible changes to the mechanical properties of dentine. 122 The substantivity of these compounds may be attributed to the mesoporous structure which allows these compounds to carry antimicrobial nanoparticles and support their sustained release.…”

Section: Intracanal Medicamentsmentioning

confidence: 99%

“… 126 Apart from their potential use as intracanal disinfectants, several authors have also advocated the development of calcium silicate nanoparticles into novel root canal sealers due to the aforementioned benefits. 121 , 122 , 126 …”

Section: Intracanal Medicamentsmentioning

confidence: 99%

The Potential Translational Applications of Nanoparticles in Endodontics

Wong

Zou

Lee

et al. 2021

IJN

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Nanotechnology has substantially progressed in the past decades, giving rise to numerous possible applications in different biomedical fields. In particular, the use of nanoparticles in endodontics has generated significant interest due to their unique characteristics. As a result of their nanoscale dimensions, nanoparticles possess several properties that may enhance the treatment of endodontic infections, such as heightened antibacterial activity, increased reactivity and the capacity to be functionalized with other reactive compounds. Effective disinfection and sealing of the root canal system are the hallmarks for successful endodontic treatment. However, the presence of bacterial biofilms and resistance to endodontic disinfectants pose a significant challenge to this goal. This has encouraged the investigation of antibacterial nanoparticle-based irrigants and intracanal medicaments, which may improve the elimination of endodontic infections. In addition, photosynthesizer-functionalized nanoparticles could also serve as a worthy adjunct to root canal disinfection strategies. Furthermore, despite the myriad of commercially available options for endodontic obturation, the “ideal” material has yet to be conceived. This has led to the development of various experimental nanoparticle-incorporated obturation materials and sealers that exhibit a range of favourable physicochemical properties including enhanced antibacterial efficacy and bioactivity. Nanoparticle applications also show promise in the field of regenerative endodontics, such as supporting the release of bioactive molecules and enhancing the biophysical properties of scaffolds. Given the constantly growing body of research in this field, this article aims to present an overview of the current evidence pertaining to the potential translational applications of nanoparticles in endodontics.

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<p>The Antibiofilm Activity and Mechanism of Nanosilver- and Nanozinc-Incorporated Mesoporous Calcium-Silicate Nanoparticles</p>

Cited by 50 publications

References 38 publications

Biogenic ZnO Nanoparticles Synthesized from Origanum vulgare Abrogates Quorum Sensing and Biofilm Formation in Opportunistic Pathogen Chromobacterium violaceum

Biogenic ZnO Nanoparticles Synthesized from Origanum vulgare Abrogates Quorum Sensing and Biofilm Formation in Opportunistic Pathogen Chromobacterium violaceum

Microbiological Aspects of Root Canal Infections and Disinfection Strategies: An Update Review on the Current Knowledge and Challenges

The Potential Translational Applications of Nanoparticles in Endodontics

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