<p>The Association Between Subclinical Hypothyroidism and Sleep Quality: A Population-Based Study</p>

Abstract

Background and AimThe relationship between subclinical hypothyroidism (SHYPO) and sleep quality is still unclear. Our objective was to compare the sleep quality between SHYPO patients and a control group with normal thyroid function.MethodsA total of 2224 patients with SHYPO and 12,622 euthyroid (EUTH) control group patients were included in the present study. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. The sleep outcomes were compared to explore the association between SHYPO and sleep quality. Furthermore, we tried to identify the risk factors of poor sleep in SHYPO patients.ResultsCompared to the EUTH control patients, SHYPO patients had a higher PSQI score (6.83 ± 2.67 vs 6.64 ± 2.63, p =0.004) and a higher proportion of poor sleepers (67.09% vs 64.75%, p =0.033). Moreover, subjects with SHYPO were associated with poorer sleep (Odd Ratio (OR) 1.120, 95% Confidence Intervals (CI) 1.016 to 1.235, p =0.023), longer sleep latency (OR 1.162, 95% CI 1.053 to 1.282, p =0.003), and shorter sleep duration (OR 1.148, 95% CI 1.019 to 1.293, p =0.023) after adjusting for potential confounders. Furthermore, we found that lower age, lower body mass index, and women were risk factors for poor sleep quality in SHYPO patients.ConclusionOur findings suggest a relationship between SHYPO and poor sleep quality in a large Chinese population.

Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank

“…A previous study has also linked reductions in intrinsic functional connectivity in the somatomotor network to participants with subclinical hypothyroidism compared to controls 27 . Interestingly, studies have also found subclinical thyroid dysfunction to be associated with sleep quality 28 , 29 . Other genes located in this intergenic region near PAX8 include CBWD2 and CHCHD5, which have also been associated with sleep duration in prior studies 30 , 31 .…”

Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank

“…A previous study has also linked reductions in intrinsic functional connectivity in the somatomotor network to participants with subclinical hypothyroidism compared to controls 27 . Interestingly, studies have also found subclinical thyroid dysfunction to be associated with sleep quality 28,29 . Considering that we also observed phenotypic correlations between sleep duration, insomnia and graph theory measures, it is possible that PAX8 variants may play a role in the regulation of genes associated with functional brain network properties and sleep.…”

Thyroid Dysfunction and Sleep Disorders

“…Although no direct biochemical connection has been established between hypothyroidism and insomnia, some studies have shown a relationship between untreated subclinical hypothyroidism and poor sleep quality. Song et al ( 8 ) showed that people with lower thyroid hormone levels or even subclinical hypothyroidism generally have longer sleep latency, shorter sleep duration, and lower satisfaction with their sleep quality compared with euthyroid individuals. However, a study by Akatsu et al ( 9 ) did not show a relationship between subclinical hypothyroidism and sleep quality.…”