<p>The comparison of the effect of curcumin with nystatin on inhibition level of <em>Candida albicans</em></p>

Abstract

Background Curcumin is a kind of medicinal plant, a member of the ginger family, Zingiberaceae. As the herbal medicine has been globally demanded in recent years and due to the anti-viral, anti-inflammatory, and antifungal properties of curcumin, the present study aimed to compare the inhibitory effect of curcumin with that of nystatin on Candida albicans growth. Methods In this experimental study, the antifungal effect of curcumin on Candida albicans was evaluated. Candida albicans is cultivated in Agar Sabuard medium containing chlorophenic, 10-series of curcumin extract, and one 10-series of a disc impregnated with nystatin. Inside of each plate, one disc of herbal extract, one disc of nystatin as a positive control, one disc of methanol and one empty disc as negative control were placed, after 24 hrs, the inhibitory zone diameter of the herbal extract was compared with that of positive control using Mann–Whitney. Results The mean of inhibitory zone diameter in nystatin and curcumin was 1.04±20.46 and 1.36±0.89 mm, respectively. Mann–Whitney test shows a significant difference between the inhibitory zone diameter of these materials ( P <0.001). Conclusion The results of this study suggested that curcumin extract did not have any effect on the inhibition of Candida albicans in laboratory environment.

Effectiveness of photodynamic therapy with curcumin against Candida species: A systematic review

“…In the study of Wiench et al, the 635 nm diode laser alone is ineffective but PDT with toluidine blue significantly reduces all three species of C. albicans, C. glabrata, and C. krusei [49] . In the present reviewed study, three radiation wavelengths of 650, 405 and 532 nm of diode laser and LED alone, generally had no effect, but in combination with Cur (superior result), erythrosine and toluidine blue, it showed a fungicidal effect [28,[30][31][32] which is similar to findings of the other studies [43,[50][51][52] .…”

“…As in other studies, Cur had a weaker effect on Candida spp. than azoles, nystatin and amphotericin B [50,[52][53][54] . Cur in combination with fluconazole and amphotericin B [44,50] reduces the MIC of fluconazole and amphotericin B and enhances their effectiveness [34,44] .…”

Potential of Herbal Medicine in Asia for Oral Candidiasis Therapy: A Systematic Review

“…Cinnamomum zealanicum [14], Ocimum basilicum [14], Foeniculum vulgare [19], Citrus limon [14], Citrus aurantifolia [14], Citrus hystrix [14], Citrus sinensis [14], Alpinia galanga [14], Allium sativum [15,24], Curcuma longa [21,22], Cocos nucifera [14], Mentha spicata [14],…”

Investigation of the effect of curcumin and nystatin, independently and in combination, on Candida albicans biofilm formation in laboratory settings

“…The MIC cutoff was considered as the minimum concentration of uconazole, nystatin, curcumin, and a combination of curcumin and nystatin that caused visible growth reduction in the broth dilution sensitivity test [15].…”