&lt;p&gt;The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats&lt;/p&gt;

Tunçay, Aydın; Şıvgın, Volkan; Özdemirkan, Aycan; Sezen, Şaban Cem; Boyunağa, Hakan; Küçük, Ayşegül; Güneş, İbrahim; Arslan, M

doi:10.2147/ijn.s263001

“…The application of drugs in this way may also be considered as preconditioning. It has been proposed that antioxidant substances show their effects by preventing the increase in pulmonary microvascular permeability, neutrophil adhesion and accumulation or by binding to free oxygen radicals, thus showing their protective effects against distant organ injury that develop after I/R [ 10 , 11 , 27 , 28 , 29 ] In our study, positive results could only be achieved by propofol, and remifentanil showed no preventive effects on the injury.…”

Section: Discussionmentioning

confidence: 50%

“…Various studies have shown the protective effects of antioxidant compounds against distant organ injury developing after acute I/R injury. Although there have been a large number of drugs or substances that have been studied for their antioxidant effects and are being used for that purpose, anesthetic substances have a different and important place among them [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. One of these anesthetic substances that have been greatly emphasized is propofol.…”

Section: Introductionmentioning

confidence: 99%

Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model

Kanbak¹,

Aydogan²,

Gümüş

³

2021

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Our aim was to evaluate lung injury due to oxidative stress and antioxidant activity levels in an infrarenal ischemia–reperfusion model and to compare prevention effects of single and combined use of propofol and remifentanil. In this study, a total of 40 adult Wistar Albino rats were randomly divided into five groups of eight rats as SHAM, physiological saline, intraperitoneal propofol, remifentanil, and propofol and remifentanil groups. Blood and tissue samples were obtained after 80 min of reperfusion. The malondialdehyde (MDA) level, a measure of lipid peroxidation, was measured in lung tissue samples and red blood cells; additionally, total oxidant status and total antioxidant capacity of lung tissues were measured and histopathological examination was performed. Distant organ (lung) injury developed due to lower extremity ischemia–reperfusion was created by infrarenal aortic clamping. The lipid peroxidation product MDA and total oxidant levels were increased, but there was insufficient antioxidant protection both in the lung tissues and red blood cells. While propofol prevented this injury consistent with its proposed antioxidant properties; no protective effect of remifentanil was observed. On the contrary, it showed oxidative stress increasing effect. This study concluded that the antioxidant effect of propofol was suppressed by remifentanil in the case of combined use.

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“…Cerium oxide was given (0.5 mg/kg, ip) 30 minutes before the incision. Cerium oxide was given at the predetermined dose [ 16 ] Torsion-detorsion group (T/D): testis torsion/detorsion was performed surgically as described Cerium oxide-torsion-detorsion group (CeO 2 -T/D): testis torsion/detorsion was performed surgically as described. Cerium oxide was given (0.5 mg/kg , ip) 30 minutes before the ischemia period …”

Section: Methodsmentioning

confidence: 99%

Effect of Cerium Oxide on Kidney and Lung Tissue in Rats with Testicular Torsion/Detorsion

Özdemirkan

¹

,

Kurtipek²,

Küçük³

et al. 2022

BioMed Research International

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Introduction. Testicular torsion is a surgical emergency that results in testicular ischemia as a result of rotation of the spermatic cord around itself. Oxidative damage occurs in the testis and distant organs with the overproduction of free radicals and overexpression of proinflammatory cytokines by reperfusion after surgery. In this study, we aimed to investigate the effects of cerium oxide (CeO2), an antioxidant nanoparticle, on lung and kidney tissues in testicular torsion/detorsion (T/D) in rats. Materials and Methods. After ethics committee approval, 24 rats were equally (randomly) divided into 4 groups. Left inguinoscrotal incision was performed in the control (C) group. In group CeO2, 0.5 mg/kg CeO2 was given intraperitoneally 30 minutes before inguinoscrotal incision. In group T/D, unilateral testicular T/D was achieved by performing an inguinoscrotal incision and rotating the left testis 720° clockwise, remaining ischemic for 120 minutes, followed by 120 minutes of reperfusion. In group CeO2-T/D, 0.5 mg/kg CeO2 was given intraperitoneally 30 minutes before testicular T/D. At the end of the experiment, lung and kidney tissues were removed for histopathological and biochemical examinations. Results. Glomerular vacuolization (GV), tubular dilatation (TD), tubular cell degeneration and necrosis (TCDN), leukocyte infiltration (LI), and tubular cell spillage (TCS) in renal tissue were significantly different between groups ( p = 0.012 , p = 0.049 , p < 0.003 , p = 0.046 , and p = 0.049 , respectively). GV and TCDN were significantly decreased in group CeO2-T/D compared to group T/D ( p = 0.042 and p = 0.029 , respectively). Lung tissue neutrophil infiltration, alveolar thickening, and total lung injury score (TLIS) were significantly different between groups ( p = 0.006 , p = 0.001 , and p = 0.002 , respectively). Neutrophil infiltration and TLIS were significantly decreased in group CeO2-T/D compared to group T/D ( p = 0.013 and p = 0.033 , respectively). Lung and kidney tissue oxidative stress parameters were significantly different between groups ( p < 0.05 ). Renal tissue glutathione-s-transferase (GST), catalase (CAT), and paraoxonase (PON) activities were significantly higher, and malondialdehyde (MDA) levels were significantly lower in group CeO2-T/D than in group T/D ( p = 0.049 , p = 0.012 , p < 0.001 , and p = 0.004 , respectively). GST and PON activities were higher, and MDA levels were lower in group CeO2-T/D than in group T/D in the lung tissue ( p = 0.002 , p < 0.001 , and p = 0.008 , respectively). Discussion. In our study, cerium oxide was shown to reduce histopathological and oxidative damage in the lung and kidney tissue in a rat testis torsion/detorsion model.

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“…Group IRI: midline laparotomy was performed, followed by 120 minutes of ischemia by clamping the infrarenal abdominal aorta by placing an atraumatic microvascular clamp, and then 120 minutes of reperfusion. 7 Group IRICO: 0.5mg/kg IP cerium oxide (Sigma-Aldrich, Co. St. Louis, MO, USA) was administered. Midline laparotomy was performed 30 minutes following the administration of CO, followed by 120 minutes ischemia and 120 minutes of reperfusion.…”

Section: Brief Communicationmentioning

confidence: 99%

“…[4][5][6] In our previous study, the combined effects of sevoflurane and CO on lung injury were investigated and it was revealed that they showed a stronger lung protective effect than their individual effects. 7 In this study, we aimed to study the combined effects of desflurane and CO on lung tissue following lower extremity IRI in rats.…”

mentioning

confidence: 99%

The effect of cerium oxide on lung injury following lower extremity ischemia-reperfusion injury in rats under desflurane anesthesia

Özdemirkan¹,

Küçük²,

Güneş³

et al. 2021

SMJ

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Objectives: To examine the effects of desflurane and cerium oxide (CO) on lung tissue following ischemia-reperfusion injury (IRI). Methods: Experiments were conducted in Gazi University Animal Laboratory, Ankara, Turkey. Thirty rats were divided into 5 groups: control (C), IRI, IRI-CO, IRI-desflurane (IRID), IRI-CO-desflurane (IRICOD). Cerium oxide was given intraperitoneally. Lower extremity IRI was induced. Desflurane was applied during IRI. Lung histopathological examinations and serum biochemical analyses were performed. Results: Serum nitric oxide (NO) and malondialdehyde (MDA) levels were higher in group IRI ( p =0.006) than in group C ( p =0.001). Serum MDA and NO levels were significantly lower in groups IRICO and IRICOD than in group IRI. Significantly greater alveolar wall thickening and neutrophil infiltration were recorded in group IRI than in group C. Co-administration of desflurane and CO significantly decreased alveolar wall thickening and neutrophil infiltration compared to group IRI. Total lung injury scores were significantly lower in groups IRID, IRICO, and IRICOD than in group IRI. Conclusion: Intraperitoneal CO with desflurane, reduced oxidative stress and corrected the damage in lung. Cerium oxide given before and desflurane given during IRI have been shown to have protective effects on lung damage in rats.

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<p>The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats</p>

Cited by 14 publications

References 48 publications

Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model

Effects of remifentanil and propofol on distant organ lung injury in an ischemia–reperfusion model

Effect of Cerium Oxide on Kidney and Lung Tissue in Rats with Testicular Torsion/Detorsion

The effect of cerium oxide on lung injury following lower extremity ischemia-reperfusion injury in rats under desflurane anesthesia

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