&lt;p&gt;Visceral Fat Area, Not Subcutaneous Fat Area, is Associated with Cardiac Hemodynamics in Type 2 Diabetes&lt;/p&gt;

Qiu, Yue; Deng, Xia; Sha, Yujing; Wu, Xunan; Zhang, Panpan; Chen, Ke; Zhao, Zhicong; Wei, Weiping; Yang, Licong; Yuan, Guoyue; Zhao, Li; Wang, Dong

doi:10.2147/dmso.s284420

Cited by 14 publications

(19 citation statements)

References 39 publications

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“…BMI as the traditional anthropometric parameter can only evaluate the total body fat, but not the fat distribution. In recent years, it has been discovered that central obesity with excessive accumulation of visceral fat significantly increases the risk of atherosclerosis, type 2 diabetes, cancer, and all-cause mortality ( Liu et al., 2019 ; Qiu et al., 2020 ; Xiong et al., 2021 ). This may be because the visceral fat is more active in storing dietary fatty acids, secreting adiponectin and inflammatory factors such as interleukin-6, tumor necrosis factor (TNF)-α, and colony-stimulating factor-1 ( Fontana et al., 2007 ; Harman-Boehm et al., 2007 ; Cartier et al., 2008 ; Kovacova et al., 2012 ; Wang et al., 2012 ; Huang et al., 2015 ; Tsujimoto and Kajio, 2017 ; Barberio et al., 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Gut Microbiome Alterations in Patients With Visceral Obesity Based on Quantitative Computed Tomography

Yan

Qin

Chen

et al. 2022

Front. Cell. Infect. Microbiol.

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The gut microbiota is crucial in the pathogenesis of obesity. Abdominal obesity is known to significantly increase the risk of metabolic syndrome and cardiovascular disease, so further study is needed to investigate the changes of intestinal microorganisms in patients with excessive visceral fat. In our study, 41 people (n = 41) with normal body mass index (BMI) (18.5 ≤ BMI < 23.9) were included and divided into the low visceral fat area (L-VFA) group (n = 23, VFA < 100 cm2) and the high visceral fat area (H-VFA) group (n = 18, VFA ≥ 100 cm2). Several clinical indicators of the H-VFA group were significantly higher than those of the L-VFA group, including the waist circumference (WC), the fasting blood glucose (FBG), the triglyceride (TG), the total cholesterol (TC), the low-density lipoprotein cholesterol (LDL), the serum uric acid (SUA), the white blood cell count (WBC), the blood neutrophil count (NEC), and the blood lymphocyte count (LYC). Using whole-genome shotgun sequencing, we found that the types of the intestinal microbiota of H-VFA patients were different from those of the L-VFA patients, with 18 bacteria enriched in the H-VFA group and nine bacteria in the L-VFA group. A total of 16 species of gut microbes showed a strong correlation with VFA, and Escherichia coli has the strongest correlation, followed by Mitsuokella unclassified, Bifidobacterium longum, Escherichia unclassified, Ruminococcus torques, Dialister succinatiphilus, Eubacterium hallii, and Ruminococcus gnavus. Compared to the VFA, only two species show a strong correlation with BMI and WC. Further functional genetic studies suggested that the degradation of short-chain fatty acids (SCFAs) and the generation of lipopolysaccharide (LPS) might be related to visceral fat accumulation. Together, visceral fat was more closely correlated with the gut microbiome compared with BMI and WC. It suggested an intrinsic connection between the gut microbiome and visceral fat and its related metabolic disorders. Specific microbial species and pathways associated with visceral fat accumulation might contribute to new targeted therapies for visceral fat and its metabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Gut Microbiome Alterations in Patients With Visceral Obesity Based on Quantitative Computed Tomography

Yan

Qin

Chen

et al. 2022

Front. Cell. Infect. Microbiol.

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show abstract

“…Previous studies demonstrated that obesity and diabetes affect LV structure and function [9,29]. A previous study [10] showed that in T2DM patients, VFA, but not SFA, had a significant correlation with cardiac hemodynamic parameters; yet, BMI was not included in the adjustment factors. Moreover, Ichikawa et al [9] found that BMI was not related to the echocardiographic parameters, while VF, normalized according to body surface area, was found to have a greater role than glycemic control in the development of diastolic dysfunction and LV hypertrophy in T2DM.…”

Section: Discussionmentioning

confidence: 99%

“…However, BMI cannot distinguish the disproportion of adiposity, including visceral and subcutaneous fat mass. Several studies [9,10] have suggested that visceral fat (VF) is closely associated with cardiac structure and function; also, some studies indicated that the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA) (V/S ratio) might be a better predictor of atherosclerosis and cardiovascular events in patients with T2DM than VFA or SFA alone [11]. Yet, VF's effect on cardiac structure and function in obese subjects and those with normal weight might be different.…”

Section: Introductionmentioning

confidence: 99%

Visceral fat might impact left ventricular remodeling through changes in arterial stiffness in type 2 diabetes: A cross-sectional study

Huang¹,

Jin²,

Chen³

et al. 2022

International Journal of Cardiology

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“…For example, studies have recommended measuring the area of visceral or subcutaneous fat to evaluate the association between abdominal obesity and multiple adverse outcomes. 10–12 This evidence has provided more practical suggestions to diagnose and manage obesity.…”

Section: Introductionmentioning

confidence: 95%

Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population

Wang¹,

Wang²,

Li³

et al. 2021

DMSO

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<p>Visceral Fat Area, Not Subcutaneous Fat Area, is Associated with Cardiac Hemodynamics in Type 2 Diabetes</p>

Cited by 14 publications

References 39 publications

Gut Microbiome Alterations in Patients With Visceral Obesity Based on Quantitative Computed Tomography

Gut Microbiome Alterations in Patients With Visceral Obesity Based on Quantitative Computed Tomography

Visceral fat might impact left ventricular remodeling through changes in arterial stiffness in type 2 diabetes: A cross-sectional study

Combined Effects of Dyslipidemia and High Adiposity on the Estimated Glomerular Filtration Rate in a Middle-Aged Chinese Population

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