&lt;title&gt;A possible mechanism for visible-light-induced skin rejuvenation&lt;/title&gt;

Longo, Leonardo; Lubart, Rachel; Friedman, H.; Lavie, Ronit

doi:10.1117/12.584393

Cited by 5 publications

(7 citation statements)

References 8 publications

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“…The therapeutic approaches used in the present study showed favorable responses in the healing of burn wounds. In this respect, microcurrent stimulation probably contributed to the normalization of alterations of bioelectricity promoted by injury and also ATP production, protein synthesis, oxygenation and ion exchange [75,76], whereas laser therapy increased cell metabolism, vascular activity, anti-inflammatory effects, and consequently, favored the healing process [22,77].…”

Section: Discussionmentioning

confidence: 99%

Application of 670 nm InGaP laser and microcurrent favors the healing of second-degree burns in Wistar rats

et al. 2014

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The treatment of burn wounds has been a challenge due to their severity and associated multiple complications, and represents a major public health problem. This study investigated the effects of 670 nm InGaP laser irradiation and microcurrent (10 µA) stimulation on the healing of second-degree burns inflicted on the back of Wistar rats. Seventy-two animals were divided into four groups: no treatment (C); animals irradiated with a 670 nm InGaP laser (L); animals receiving microcurrent stimulation (10 µA/3 min) (MC); animals receiving 670 nm InGaP laser therapy and microcurrent stimulation (10 µA/3 min) on alternate days (MCL). Wound samples were collected on days 7, 14 and 21 of treatment for structural and morphometric analysis and for Western blotting to quantify the expression of TGF-β1 and VEGF. The applied alone and alternate of laser and microcurrent reduced the number of inflammatory cells and increased the number of newly formed vessels and fibroblasts, collagen fiber content and fiber reorganization. The two treatments also favorably modified the expression of VEGF and TGF-β1, inducing angiogenesis and decreasing the inflammation time.

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Section: Discussionmentioning

confidence: 99%

Application of 670 nm InGaP laser and microcurrent favors the healing of second-degree burns in Wistar rats

et al. 2014

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“…The mechanisms of these kinds of therapy are different. The application of the microcurrent produces electrical signals like those produced by the physiological electromagnetic field, normalizing the natural bioelectricity altered by the lesion, increasing ATP production, protein synthesis, oxygenation, ion exchange and elimination of catabolites [59], whereas the application of the laser promotes selective stimulation of mitochondria, increasing the cellular metabolism and aiding tissue repair [60]. However, the biomodulatory effects or photobiorregulators assigned to the microcurrent and the laser are similar in their interaction with the tissue, stimulating or inhibiting it biochemically or biophysically.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of the application of microcurrent and AsGa 904 nm laser radiation in the process of repair after calvaria bone excision in rats

Mendonça¹,

Neves²,

Esquisatto³

et al. 2013

Laser Phys.

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This study evaluated the effects of microcurrent stimulation (10 µA/5 min) and 904 nm GaAs laser irradiation (3 J cm −2 for 69 s/day) on excisional lesions created in the calvaria bone of Wistar rats. The results showed significant responses in the reduction of inflammatory cells and an increase in the number of new blood vessels, number of fibroblasts and deposition of birefringent collagen fibers when these data were compared with those of samples of the untreated lesions. Both applications, microcurrent and laser at 904 nm, favored tissue repair in the region of bone excisions during the study period and these techniques can be used as coadjuvantes in the repair of bone tissue.

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“…The mechanisms of these kinds of therapy are different. The application of the microcurrent produces electrical signals like those produced by the physiological electromagnetic field, normalizing the natural bioelectricity altered by the lesion, increasing ATP production, protein synthesis, oxygenation and ion exchange [70], whereas the application of the laser promotes selective stimulation of mitochondria, increasing the cellular metabolism and aiding tissue repair [71]. The alternating application of these techniques proved to be more effective, probably due to their differential effects on the various mechanisms necessary for the development of tissue repair.…”

Section: Discussionmentioning

confidence: 99%

Effects of microcurrent application and 670 nm InGaP low-level laser irradiation on experimental wound healing in healthy and diabetic Wistar rats

et al. 2013

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This study evaluated the effects of microcurrent application and 670 nm InGaP laser irradiation on wound healing in healthy and alloxan diabetic rats. The animals were divided into eight groups: healthy control (HC); diabetic control (DC); healthy treated with microcurrent (HMC); diabetic treated with microcurrent (DMC); healthy irradiated with laser (HL); diabetic irradiated with laser (DL); healthy receiving laser and microcurrent application (HLMC) and diabetic receiving laser and microcurrent application (DLMC). Wound samples were collected on days 2, 6, 10 and 14 of treatment for structural analysis, morphometry, and Western blotting to quantify the expression of TGF-β1 and VEGF. Comparison of animals receiving laser and microcurrent therapy showed a reduction in the number of inflammatory cells in diabetic animals, as well as an increase of fibroblasts in healthy animals and of newly formed vessels in healthy and diabetic animals. Expression of TGF-β1 was increased on day 6 in all groups, especially diabetic animals. A reduction in the expression of this protein was observed on day 10 in all groups. VEGF expression was higher on day 6 in treated and control diabetic animals when compared to healthy animals. Analysis of VEGF expression in the laser-and microcurrent-treated groups on day 10 showed a decrease in diabetic animals and an increase in healthy animals. In conclusion, laser therapy and microcurrent stimulation exert beneficial effects on wound healing in both healthy and diabetic animals.

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<title>A possible mechanism for visible-light-induced skin rejuvenation</title>

Cited by 5 publications

References 8 publications

Application of 670 nm InGaP laser and microcurrent favors the healing of second-degree burns in Wistar rats

Application of 670 nm InGaP laser and microcurrent favors the healing of second-degree burns in Wistar rats

Comparative study of the application of microcurrent and AsGa 904 nm laser radiation in the process of repair after calvaria bone excision in rats

Effects of microcurrent application and 670 nm InGaP low-level laser irradiation on experimental wound healing in healthy and diabetic Wistar rats

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