&lt;title&gt;Acute effects of short-term intimal heating by laser-heated thermal balloon angioplasty in canine stenotic femoral arteries in vivo&lt;/title&gt;

Miyamoto, Akira; Sakurada, Masami; Arai, Tsunenori; Mizuno, Kyoichi; Sugiyabu, Yasunori; Kurita, Akira; Nakamura, Haruo; Kikuchi, Makoto; Watanabe, Tamishige; Utsumi, Atsushi; Akai, Yoshiro; Takeuchi, Kiyoshi

doi:10.1117/12.146577

Cited by 8 publications

(4 citation statements)

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“…We have obtained sufficient arterial dilatation with short-duration heating and low dilatation pressure on both acute and chronic phase in our previous in vivo canine and rabbit studies. 2 , 14 , 24 The mechanism of our short-duration heating dilatation have been reported 21 ; (i) reversible collagen thermal denaturation and stretch-fixing of elastin occur during short-duration heating balloon dilatation, and (ii) collagen fiber orients circumferentially and reconstructs with the temperature decrease after short-duration heating. Therefore, the arterial dilatation with our short-duration heating dilatation was performed without any vascular injuries, which are the main causes of the restenosis after the balloon angioplasty.…”

Section: Introductionmentioning

confidence: 82%

“…Low dilatation pressure (<0.4 MPa) can be used in our short-duration heating dilatation because the vessel wall becomes softened by heating. We have obtained sufficient arterial dilatation with short-duration heating and low dilatation pressure on both acute and chronic phase in our previous in vivo canine and rabbit studies 2,14,24. The mechanism of our short-duration heating dilatation have been reported21; (i) reversible collagen thermal denaturation and stretch-fixing of elastin occur during short-duration heating balloon dilatation, and (ii) collagen fiber orients circumferentially and reconstructs with the temperature decrease after short-duration heating.…”

Section: Introductionmentioning

confidence: 83%

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The Deformation Rate of Smooth Muscle Cells in Vessel Walls After Short-Duration Heating Dilatation in a Porcine Model Ex Vivo and In Vivo

Kunio

Arai

2012

Cardiovasc Eng Tech

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We have proposed a novel short-duration thermal angioplasty with uniform temperature distribution. Although the dilatation mechanism of our short-duration heating dilatation was reported in our previous study, the influences on smooth muscle cells (SMCs) are not sufficiently understood. We studied the influences on SMCs in terms of shape change and discussed the relationship between the SMCs’ shape change and dilatation mechanism ex vivo and in vivo. We found that the SMCs were fixed in the stretched condition after our short-duration heating dilatation both ex vivo and in vivo. The deformation rate of SMCs’ shape, measured by the cells’ nuclei, was increased with rising balloon maximum temperature (Tballoon), and the same tendency was observed for the arterial dilatation rate. We hypothesize that the SMCs were fixed in the stretched condition because the arterial dilatation with our short-duration heating dilatation was performed without any plastic deformations of the vessel wall, causing the vessel wall itself to be stretched. We also prospect that the reasons for the positive correlation between the deformation rate of SMCs’ shape and Tballoon are that (i) the area heated over 60 °C was expanded with rising Tballoon, and (ii) the arterial dilatation rate was also increased with rising Tballoon.

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Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 83%

The Deformation Rate of Smooth Muscle Cells in Vessel Walls After Short-Duration Heating Dilatation in a Porcine Model Ex Vivo and In Vivo

Kunio

Arai

2012

Cardiovasc Eng Tech

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“…With PTDBA, the arterial dilatation without vascular injuries was attained by "short-term" vascular heating (< 15 s, < 70 °C) and "low" dilatation pressure (< 0.4 MPa) in our previous studies [7,8]. The balloon for PTDBA has the mechanism which can realize the short-term heating [9].…”

Section: Introductionmentioning

confidence: 99%

“…The balloon for PTDBA has the mechanism which can realize the short-term heating [9]. The chronic restenosis was prevented compared to the conventional balloon angioplasty [8,10] because (i) the arterial dilatation with PTDBA was performed without vascular injuries and (ii) a part of the smooth muscle cells in the media was died by short-term heating. The concept of thermal angioplasty, dilating the arteries without the vascular injuries by vascular heating, had been already proposed in late 1980s by Spears et al [11] and Becker et al [12].…”

Section: Introductionmentioning

confidence: 99%

Basic study of effects on the smooth muscle cells' proliferation with novel short-term thermal angioplasty in vitro and in vivo

et al. 2011

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We investigated the effect on smooth muscle cells' proliferation with stretch-fixing in both in vitro and in vivo porcine study to determine the optimum heat condition of novel short-term thermal angioplasty, Photo-thermo Dynamic Balloon Angioplasty (PTDBA). With PTDBA, we have obtained the sufficient arterial dilatation by short-term heating (< 15 s, < 70 °C) and low dilatation pressure (< 0.4 MPa) without excessive neo-intimal hyperplasia on chronic phase. The smooth muscle cells were found to be fixed with stretched shape in vascular wall after PTDBA in vivo. The deformation rate of smooth muscle cells' nuclei was 1.6 ± 0.1 after PTDBA (15 s, 65 °C, 0.35 MPa). The smooth muscle cells, which were extracted from porcine arteries, were cultured on the specially designed equipment to give stretch-fixing stimulus in vitro. The cell proliferation was inhibited at 20 % stretching compared to 15 % stretching significantly (p < 0.05). The immunostaining specimens of basic Fibroblast Growth Factor (bFGF) and its receptor FGFR-1 were made from the porcine arteries in vivo. We found that the expressions of bFGF and FGFR-1 in the media were not observed after PTDBA. We think that these results suggested the possibility for the inhibition of the excessive cell proliferation after PTDBA.

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Vessel wall temperature estimation for novel short term thermal balloon angioplasty: study of thermal environment

Kaneko

Nakatani

Futami

et al. 2005

2005 IEEE Engineering in Medicine and Biology 27th Annual Conference

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We have been proposing novel thermal balloon angioplasty, photo-thermo dynamic balloon angioplasty (PT-DBA). PTDBA realized <10s short term heating that can prevent surrounding tissue thermal injury and low pressure dilatation that can prevent restenosis in chronic phase. We aim to determine the most efficient heating condition suit to individual symptom with pre-operation thermal simulation. We analyzed the flow dynamics and heat convection inside the balloon, and investigated heat conduction of balloon film to establish the temperature estimation method among vessel wall. Compared with ex vivo temperature measurement experiment, we concluded that the factors need to be considered for the establishment would be the heat conduction of the flow inside PTDB, heat conduction at the balloon film, and contact thermal resistance between the balloon film and vessel wall.

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<title>Acute effects of short-term intimal heating by laser-heated thermal balloon angioplasty in canine stenotic femoral arteries in vivo</title>

Cited by 8 publications

References 0 publications

The Deformation Rate of Smooth Muscle Cells in Vessel Walls After Short-Duration Heating Dilatation in a Porcine Model Ex Vivo and In Vivo

The Deformation Rate of Smooth Muscle Cells in Vessel Walls After Short-Duration Heating Dilatation in a Porcine Model Ex Vivo and In Vivo

Basic study of effects on the smooth muscle cells' proliferation with novel short-term thermal angioplasty in vitro and in vivo

Vessel wall temperature estimation for novel short term thermal balloon angioplasty: study of thermal environment

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