&lt;title&gt;First results from the Philips optical mammoscope&lt;/title&gt;

Hoogenraad, J. H.; Mark, Martin B. van der; Colak, Sel-Brian B.; t'Hooft, Gert W.; Linden, E.S. van der

doi:10.1117/12.301053

Cited by 25 publications

(11 citation statements)

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“…In the past 7 or 8 years, there have been many reports published discussing the possibilities of near infrared tissue imaging, yet very few papers have addressed the technical challenges of developing an integrated system for this purpose [28,29]. One of the obvious applications for near infrared computed tomography is breast cancer detection, mainly because recent developments in diffuse computed tomography may afford better means of tissue discrimination over older clinical devices.…”

Section: Discussionmentioning

confidence: 99%

“…This paper outlines the design and development of a fully functional breast cancer screening device which should be able to provide quantitative images of absorption and diffusion coefficient maps, and the use of multiple projections with a reconstruction algorithm should provide increased spatial resolution over diaphanography [10][11][12][13][14]. While this type of imaging has been studied extensively both theoretically and in test phantoms, there have been few descriptions of automated systems for computational image reconstruction for breast cancer detection presented in the published literature [28,29]. This type of system is described here along with some representative images obtained from test phantoms.…”

Section: Introductionmentioning

confidence: 99%

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Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection

et al. 1997

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The instrument development and design of a prototype frequency-domain optical imaging device for breast cancer detection is described in detail. This device employs radio-frequency intensity modulated near-infrared light to image quantitatively both the scattering and absorption coefficients of tissue. The functioning components of the system include a laser diode and a photomultiplier tube, which are multiplexed automatically through 32 large core fiber optic bundles using high precision linear translation stages. Image reconstruction is based on a finite element solution of the diffusion equation. This tool for solving the forward problem of photon migration is coupled to an iterative optical property estimation algorithm, which uses a Levenberg-Marquardt routine with total variation minimization. The result of this development is an automated frequency-domain optical imager for computed tomography which produces quantitatively accurate images of the test phantoms used to date. This paper is a description and characterization of an automated frequency-domain computed tomography scanner, which is more quantitative than earlier systems used in diaphanography because of the combination of intensity modulated signal detection and iterative image reconstruction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection

et al. 1997

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“…5. DOT has been the focus of much effort in both academic [15, 29–35] and industrial [36–41] settings. More details about the DOT reconstruction process may be found in the recent review by Arridge and Schotland [42].…”

Section: Continuous Non-invasive Monitoring Of Blood Volume Flowmentioning

confidence: 99%

Toward Noninvasive Characterization of Breast Cancer and Cancer Metabolism with Diffuse Optics

et al. 2013

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We review recent developments in diffuse optical imaging and monitoring of breast cancer, i.e. optical mammography. Optical mammography permits non-invasive, safe and frequent measurement of tissue hemodynamics oxygen metabolism and components (lipids, water, etc.), the development of new compound indices indicative of the risk and malignancy, and holds potential for frequent non-invasive longitudinal monitoring of therapy progression.

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“…DOT has recently been applied to clinical imaging of the breast, and several prototype breast optical tomographic systems have been developed that operate using photon pulses [24], light of modulated intensity [25] or light of constant intensity [26]. Our group has demonstrated quantified DOT images of uptake of the NIR contrast agent indocyanine green (ICG) from breast lesions in a study that was performed simultaneously with gadolinium-enhanced magnetic resonance imaging (MRI) for validation [7].…”

Section: Diffuse Optical Tomographymentioning

confidence: 99%

Breast imaging technology: Probing physiology and molecular function using optical imaging - applications to breast cancer

2000

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The present review addresses the capacity of optical imaging to resolve functional and molecular characteristics of breast cancer. We focus on recent developments in optical imaging that allow threedimensional reconstruction of optical signatures in the human breast using diffuse optical tomography (DOT). These technologic advances allow the noninvasive, in vivo imaging and quantification of oxygenated and deoxygenated hemoglobin and of contrast agents that target the physiologic and molecular functions of tumors. Hence, malignancy differentiation can be based on a novel set of functional features that are complementary to current radiologic imaging methods. These features could enhance diagnostic accuracy, lower the current state-of-the-art detection limits, and play a vital role in therapeutic strategy and monitoring.

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<title>First results from the Philips optical mammoscope</title>

Cited by 25 publications

References 0 publications

Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection

Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection

Toward Noninvasive Characterization of Breast Cancer and Cancer Metabolism with Diffuse Optics

Breast imaging technology: Probing physiology and molecular function using optical imaging - applications to breast cancer

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