&lt;title&gt;Occlusion spectroscopy as a new paradigm for noninvasive blood measurements&lt;/title&gt;

Fine, Ilya; Fikhte, B. A.; Shvartsman, L. D.

doi:10.1117/12.429330

Cited by 18 publications

(18 citation statements)

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“…As with scattering and OCT, it is a surrogate measure for glucose. Erythrocyte aggregation results in enhanced transmission of light and can be reproduced in vivo by applying greater than systolic pressure to the fingertip for 2-3 s. Measuring the scatter pattern at the site of erythrocyte aggregation allows calculation of glucose concentration [45].…”

Section: Occlusion Spectroscopymentioning

confidence: 99%

Glucose sensors: a review of current and emerging technology

et al. 2009

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Glucose monitoring technology has been used in the management of diabetes for three decades. Traditional devices use enzymatic methods to measure glucose concentration and provide point sample information. More recently continuous glucose monitoring devices have become available providing more detailed data on glucose excursions. In future applications the continuous glucose sensor may become a critical component of the closed loop insulin delivery system and, as such, must be selective, rapid, predictable and acceptable for continuous patient use. Many potential sensing modalities are being pursued including optical and transdermal techniques. This review aims to summarize existing technology, the methods for assessing glucose sensing devices and provide an overview of emergent sensing modalities.

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Section: Occlusion Spectroscopymentioning

confidence: 99%

Glucose sensors: a review of current and emerging technology

et al. 2009

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“…This description for Mie scatterers, like microspheres, can be calculated by (8) and gives results similar to those obtained by using equation (4) However, RBC aggregation can not be correctly described by the Mie formula, especially for long aggregates. Therefore, we have adopted a model of aggregates approximated with WKB scattering by growing spheroid particles whereas the axis c is time dependent (starting from 2.8 microns) where another dimension of the spheroid (about 7.6 microns) is kept unchanged 9 :…”

Section: Here 'mentioning

confidence: 60%

In vivo dynamic light scattering measurements of red blood cell aggregation

Fine

Kaminsky

2007

Complex Dynamics and Fluctuations in Biomedical Photonics IV

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The tendency of red blood cells (RBCs) to aggregate is considered to be a critical biological activity, which contributes to blood viscosity. The ability to assess blood viscosity parameters non-invasively can play an important role in a variety of fields of medicine. Toward achieving this goal, we have attempted to follow the kinetics of red blood cell's aggregation process non-invasively. In this work, we have generated the optical signals of RBC aggregation and have studied them both in vitro and in vivo utilizing a dynamic light scattering (DLS) approach. The system was built and calibrated, first in vitro by using micro-sphere suspensions of known particle sizes and subsequently in vitro, on a sample of whole blood. Time dependent behavior of a function expressed in terms of autocorrelation of light intensity fluctuations was analyzed. The correspondence between in vitro aggregation tests and in vivo results was revealed and is explained in terms of modified diffusion theory and WKB approximation for light scattering mediated by aggregates. Therefore, we have demonstrated the applicability of a DLS based technique for the non-invasive measurement of blood particle sizes and blood viscosity.

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“…The time evolution of blood transparency is a rather strong signal and results in high signal to noise ratio. Studies have shown the detailed behavior of the blood transparency following occlusion as a function of time is determined by the change of light scattering due to RBC aggregation, and thus contains rich information on: the volume fraction of scatterers (hematocrit), the mismatch of refraction indexes (glucose) and average absorption of whole blood (oxygen saturation) [21][22][23][24] .…”

Section: Prspc Based Occlusion Spectrocsopy Methodsmentioning

confidence: 99%

“…Occlusion spectroscopy is a recently emerged technique which showed considerable promise for non-invasive monitoring of human blood glucose [20][21][22][23][24][25] . The major advance of this method is the use of an artificially induced time variance of optical transmission, i.e.…”

Section: Prspc Based Occlusion Spectrocsopy Methodsmentioning

confidence: 99%

Pseudo-random single photon counting system: a high speed implementation and its applications

Zhang

Chen

2011

Design and Quality for Biomedical Technologies IV

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As a new time-resolved method which combines the spread spectrum time-resolved method with single photon counting, pseudo-random single photon counting (PRSPC) has been proved to have the potential for high speed data acquisition due to high count rate achievable. A continuous wave laser modulated by a pseudo-random bit sequence is used to illuminate the sample, while single photon counting is used to build up the optical signal in response to the excitation. Periodic cross-correlation is performed to retrieve the temporal profile. Besides the high count rate, PRSPC also offers low system cost and portability which are not with the conventional time-correlated single photon counting (TCSPC). In this paper, we report a high speed PRSPC system that can be used for real time acquisition of the temporal spread function (TPSF) of diffuse photons. We also present preliminary experimental work of human blood glucose testing studies by utilizing the PRSPC system.

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<title>Occlusion spectroscopy as a new paradigm for noninvasive blood measurements</title>

Cited by 18 publications

References 0 publications

Glucose sensors: a review of current and emerging technology

Glucose sensors: a review of current and emerging technology

In vivo dynamic light scattering measurements of red blood cell aggregation

Pseudo-random single photon counting system: a high speed implementation and its applications

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