&lt;title&gt;OCT imaging of osteoarthritic cartilage: structure, polarization sensitivity, and clinical feasibility&lt;/title&gt;

Li, Xing De; Herrmann, Jürgen; Ghanta, Ravi K.; Pitris, Costas; Drexler, Wolfgang; Jesser, Christine; Stamper, Debra L.; Golden, D. E.; Martin, Scott D.; Fujimoto, James G.; Brezinski, Mark E.

doi:10.1117/12.347484

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…It has been reported that early joint degeneration is associated with cartilage thinning [17]. Our OCT reflectivity images also demonstrate that at the site of lesions articular cartilage becomes thinner.…”

Section: Ps-oct Measurementssupporting

confidence: 70%

The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography

Ugryumova¹,

Attenburrow²,

Winlove³

et al. 2005

J. Phys. D: Appl. Phys.

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Optical coherence tomography and polarization-sensitive optical coherence tomography images of equine articular cartilage are presented. Measurements were made on intact joint surfaces. Significant (e.g. × 2) variations in the intrinsic birefringence were found over spatial scales of a few millimetres, even on samples taken from young (18 month) animals that appeared visually homogeneous. A comparison of data obtained on a control tissue (equine flexor tendon) further suggests that significant variations in the orientation of the collagen fibres relative to the plane of the joint surface exist. Images of visually damaged cartilage tissue show characteristic features both in terms of the distribution of optical scatterers and of the birefringent components.

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Section: Ps-oct Measurementssupporting

confidence: 70%

The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography

Ugryumova¹,

Attenburrow²,

Winlove³

et al. 2005

J. Phys. D: Appl. Phys.

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“…Birefringence previously seen in OCT images, however, appears to be indicative of tissue state 16 . Collagenous tissues observed under polarization sensitive OCT (PS-OCT) lose birefringence when they are damaged 17 or disorganized 18 . Boer 15 used PS-OCT to image fresh bovine tendon, revealing banding parallel to the fiber axis.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography imaging of collagenous tissue microstructure

2000

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The engineering of new biomaterials requires an in-depth understanding of the structure and function of the native tissues. Optical coherence tomography (OCT) is a non-destructive technique that allows the visualization of the microstructure of biological tissues. The aim of this study was to determine if OCT could be used to identify geometric properties of tendons such as crimp pattern. Freshly harvested tendon tissue was imaged with OCT during the application of incremental axial strain. Loads were simultaneously recorded during imaging. Results revealed that birefringent banding perpendicular to the collagen fiber axis could be visualized and measured. This crimp banding disappeared at a very low strain. Birefringent banding parallel to the collagen fiber axis was also seen and it was observed that the number of parallel bands increased as strain increased. Stress-strain data was calculated and found to lie within the expected range. These results indicate that OCT may prove to be a useful tool for the non-destructive analysis of tissue microstructure.

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“…Polarimetric imaging techniques are capable of cartilage structural characterization, of finding links between cartilage structure and function, and of investigating the biomechanics of articular cartilage that covers the sliding surfaces of bones in joints [64,65]. Osteoarthritis is associated with irreversible degradation of the cartilage and consequent disruption of the normal collagen structure that can be assessed by birefringence measurements [38,66].…”

Section: Biomechanics and Tissue Engineeringmentioning

confidence: 99%

Polarization Imaging

Mujat

2011

Advances in Optical Imaging for Clinical Medicine

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<title>OCT imaging of osteoarthritic cartilage: structure, polarization sensitivity, and clinical feasibility</title>

Cited by 6 publications

References 13 publications

The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography

The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography

Optical coherence tomography imaging of collagenous tissue microstructure

Polarization Imaging

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