&lt;title&gt;Optical properties of human cranial bone in the spectral range from 800 to 2000 nm&lt;/title&gt;

Bashkatov, Alexey N.; Genina, Elina A.; Kochubey, Vyacheslav I.; Tuchin, Valery V.

doi:10.1117/12.697305

Cited by 104 publications

(99 citation statements)

References 15 publications

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“…In this letter, we report the first demonstration of PAT through an intact adult human skull. Because the human skull scatters light strongly, 9 we designed and constructed a photon recycler (PR) to reflect back-scattered light back to the skull. Differential PAT images were acquired to improve the contrast by subtracting the images corresponding to the skull only.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic tomography through a whole adult human skull with a photon recycler

et al. 2012

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Abstract. Photoacoustic tomography (PAT) of the human brain is challenging due to the fact that the skull strongly absorbs and scatters light, and attenuates and distorts ultrasound as well. For the first time, we demonstrated the feasibility of PAT through a whole adult human skull. A photon recycler (PR) was built to increase light transmittance through the skull. Both a graphite target and a canine brain were imaged through the skull. Use of the PR was found to improve the photoacoustic signal-to-noise ratio by a factor of 2.4. In addition, subtraction of photoacoustic signals that arise from light absorption within the skull significantly improved the contrast of the target. Our results indicate that PAT can potentially be applied to in vivo human brain imaging.

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Section: Introductionmentioning

confidence: 99%

Photoacoustic tomography through a whole adult human skull with a photon recycler

et al. 2012

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“…A comparison of the data obtained by us in the spectral range 800-950 nm with the data presented by Ugryumova et al [41] and Firbank et al [42] shows an accordance between them (see Figures 5 and 6). Discrepancy between these data does not prevail 20% [46]. In the spectral range from 1000 to 2000 nm, the reduced scattering coefficient decreases nonmonotonically with increasing of wavelength with peaks corresponding to the absorption bands in contrast to spectral behaviour of bone scattering in the spectral range from 800 to 1000 nm, where the reduced scattering coefficient decreases smoothly with wavelength increasing.…”

Section: Resultsmentioning

confidence: 86%

“…Comparison of the data obtained in this study and presented by other authors [41,42] shows accordance between them in the spectral range 800-1000 nm. Insignificant differences between these data can be explained by differences in the used measuring techniques and the tissue samples preparation and storage methods [46].…”

Section: Resultsmentioning

confidence: 99%

Optical Clearing of Cranial Bone

Genina

Bashkatov

Tuchin

2008

Advances in Optical Technologies

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Recommended by Stoyan TanevWe present experimental results on optical properties of cranial bone controlled by administration of propylene glycol and glycerol. Both transmittance and reflectance spectra of human and porcine cranial bone in vitro were measured. For estimation of absorption and reduced scattering coefficients of the bone, the inverse adding-doubling method was used. The decrease of reflectance of the samples under action of the immersion agents was demonstrated. The experiments have shown that administration of the immersion liquids allows for effective controlling of tissue optical characteristics that makes bone more transparent, thereby increasing the ability of light penetration through the tissue. The presented results can be used in developing of functional imaging techniques, including OCT.

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“…6 Pifferi et al 7 have measured the skull optical properties with time-resolved transmittance spectroscopy in the 650-to 1000-nm window. Finally, Bashkatov et al 8 have studied optical properties of cranial bone in the infrared spectral range. In addition to these data on human skull, Firbank et al 9 have investigated pig skull in the 650-and 950-nm window.…”

Section: Introductionmentioning

confidence: 99%

Optical properties of mice skull bone in the 455- to 705-nm range

2017

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Abstract. Rodent brain is studied to understand the basics of brain function. The activity of cell populations and networks is commonly recorded in vivo with wide-field optical imaging techniques such as intrinsic optical imaging, fluorescence imaging, or laser speckle imaging. These techniques were recently adapted to unrestrained mice carrying transcranial windows. Furthermore, optogenetics studies would benefit from optical stimulation through the skull without implanting an optical fiber, especially for longitudinal studies. In this context, the knowledge of bone optical properties is requested to improve the quantitation of the depth and volume of imaged or stimulated tissues. Here, we provide experimental measurements of absorption and reduced scattering coefficients of freshly excised mice skull for wavelengths between 455 and 705 nm. Absorption coefficients from 6 to 8 months mice skull samples range between 1.67 AE 0.28 mm −1 at 455 nm and 0.47 AE 0.07 mm −1 at 705 nm, whereas reduced scattering coefficients were in the range of 2.79 AE 0.26 mm −1 at 455 nm up to 2.29 AE 0.12 mm −1 at 705 nm. In comparison, measurements carried out on 4 to 5 weeks mice showed similar spectral profiles but smaller absorption and reduced scattering coefficients by a factor of about 2 and 1.5, respectively. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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<title>Optical properties of human cranial bone in the spectral range from 800 to 2000 nm</title>

Cited by 104 publications

References 15 publications

Photoacoustic tomography through a whole adult human skull with a photon recycler

Photoacoustic tomography through a whole adult human skull with a photon recycler

Optical Clearing of Cranial Bone

Optical properties of mice skull bone in the 455- to 705-nm range

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