<title>Single skin exposure to visible polarized light induces rapid modification of entire circulating blood: I. Improvement of rheologic and immune parameters</title>

The Effects of Daily Irradiation with Polychromatic Visible Polarized Light on Human Lymphocyte Populations

“…28 The available data indicate that visible and infrared polarized light produce structural and functional changes in the components of a small volume of blood, and that these changes are almost immediately transmitted to the entire circulating blood pool. 8,9 So far, there has been only a limited amount of literature that has documented the effects of visible light on in vivo immune responses. The anti-inflammatory cytokine content in human blood increases quickly after its transcutaneous irradiation with polychromatic visible and infrared light.…”

“…[1][2][3][4][5][6] Visible light can penetrate into epidermal and dermal layers of the skin to a depth of several millimeters and reach the superficial vasculature. 7 There it may induce transcutaneous blood photomodification 8,9 such as that seen in the phototherapy of neonatal hyperbilirubinemia with blue light. 10 Several investigators have reported that low-energy lasers may accelerate wound healing, and this phenomenon can be explained by the increased amount of immune proteins in the exudate of wounds.…”

Effect of 710-nm Visible Light Irradiation on Neuroprotection and Immune Function after Stroke

“…The underlying mechanism might be related to transcutaneous blood photomodification [42,43]. Unlike UV light, which cannot reach the hypodermic region, 710-nm wavelength light can penetrate epidermal and dermal layers and may directly interact with circulating lymphocytes to modulate immune function [44].…”

Downregulation of Tumorogenicity and Changes in the Actin Cytoskeleton of Murine Hepatoma After Irradiation with Polychromatic Visible and IR Light

“…1 Successful use of polychromatic VIS and IR irradiation for downregulation of inflammatory processes, modulation of the immune system, acceleration of wound healing, and improvement of blood microcirculation has been published. [2][3][4][5] However, attitudes toward the use of both polychromatic and monochromatic irradiation in medical practice remains reserved, because of fears about the appearance and/or stimulation of neoplastic processes. Such fears are based on the known biostimulation effects of VIS and IR irradiation and, specifically, on their ability to accelerate proliferation not only in normal cells, but also in tumors.…”