LTCC based chip for monitoring in biological applications

Czok, Mateusz; Tadaszak, R.; Bembnowicz, Paweł; Gołonka, Leszek

doi:10.1016/j.snb.2013.01.085

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…According to the well-known Lambert–Beer’s law, it is possible to determine analyte concentration based on absorbance measurements. The absorbance magnitude ( A ) can be expressed as the logarithm of the ratio of the incident light intensity ( I 0 ) and the light transmitted to the detector ( I ). , where ε is the molar attenuation coefficient of the analyte (in cm –1 M –1 ), l is the optical path length (in cm), and c is the concentration of the analyte (in M).…”

Section: Operating Principles Of Optical Sensorsmentioning

confidence: 99%

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New Trends in Fluorescent Nanomaterials-Based Bio/Chemical Sensors for Neurohormones Detection─A Review

et al. 2022

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The study of neurotransmitters and stress hormones allows the determination of indicators of the current stress load in the body. These species also create a proper strategy of stress protection. Nowadays, stress is a general factor that affects the population, and it may cause a wide range of serious disorders. Abnormalities in the level of neurohormones, caused by chronic psychological stress, can occur in, for instance, corporate employees, health care workers, shift workers, policemen, or firefighters. Here we present a new nanomaterials-based sensors technology development for the determination of neurohormones. We focus on fluorescent sensors/biosensors that utilize nanomaterials, such as quantum dots or carbon nanomaterials. Nanomaterials, owing to their diversity in size and shape, have been attracting increasing attention in sensing or bioimaging. They possess unique properties, such as fluorescent, electronic, or photoluminescent features. In this Review, we summarize new trends in adopting nanomaterials for applications in fluorescent sensors for neurohormone monitoring.

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Section: Operating Principles Of Optical Sensorsmentioning

confidence: 99%

“…The absorbance magnitude (A) can be expressed as the logarithm of the ratio of the incident light intensity (I 0 ) and the light transmitted to the detector (I). 24,25 A I I log( / ) 0 = (1)…”

Section: Operating Principles Of Optical Sensorsmentioning

confidence: 99%

New Trends in Fluorescent Nanomaterials-Based Bio/Chemical Sensors for Neurohormones Detection─A Review

et al. 2022

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“…The ceramic chip for absorbance measurement was fabricated using LTCC (low temperature co-fired ceramics) technology based on methods already described 6 . Its three-dimensional model is presented in Figure 2.…”

Section: Technologymentioning

confidence: 99%

Optical biosensor with poly[N-nonyl-3,6-bis(ethylenedioxythiophene)carbazole] matrix for monitoring of phenol derivatives

et al. 2014

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The aim of the research was to develop an enzymatic, optical biosensor which provides quick and convenient determination of phenolic compounds in aqueous solutions. The biosensing strategy concerns design, fabrication and testing of a miniature ceramic-based biosensor which is destined for in-situ substrate monitoring. The base of the measuring system was fabricated using low temperature co-fired ceramics (LTCC) technology. The biocatalyst -laccase -was immobilized on the thin film of poly[N-nonyl-3,6-bis(ethylenedioxythiophene)carbazole] which provided good binding of the enzyme to the substrate and positively affected on the catalytic activity of the protein. In order to evaluate properties of the designed biosensor, its response for various concentrations of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diamonnium sal (ABTS) was measured. The optical biosensor produced by presented method could find applications in many fields, i.e. for detection of phenolic compounds in food products and beverages, in industry for control of technological processes or for environmental monitoring.

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“…fabricated a silicon/glass microfluidic system that operated with an external spectrofluorimeter, and achieved 0.1 mg/mL. An LTCC‐based microfluidic system with fluorescence detection was presented by Czok et al . Their system was able to detect 0.02 g/mL of fluorescein.…”

Section: Introductionmentioning

confidence: 99%

“…Bargiel et al 31 fabricated a silicon/glass microfluidic system that operated with an external spectrofluorimeter, and achieved 0.1 mg/mL. An LTCC-based microfluidic system with fluorescence detection was presented by Czok et al 32 Their system was able to detect 0.02 g/mL of fluorescein. The lowest limit of detection was achieved by Irawan et al 33 They developed a polymeric system which was able to detect 0.01 ng/mL of fluorescein.…”

Section: Introductionmentioning

confidence: 99%

The Implementation of Fluorescence‐Based Detection in LTCC (Low‐Temperature‐Co‐Fired‐Ceramics) Microfluidic Modules

Malecha¹

2015

Int J Applied Ceramic Tech

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The possibility of the application of fluorescence‐based detection method in a microfluidic system is discussed. It consists of a microfluidic module and complementary housing. Both parts are made from LTCC technology. Three microfluidic module designs are analysed. They vary by way of their constructions of a transparent window, which is used for the transmission of a fluorescence signal from the module to the photodetector integrated onto the housing. The influence of the type of materials used for optical windows on performance of the system is discussed. According to the performed measurements, a concentration as low as 0.03 ng/mL was detected.

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LTCC based chip for monitoring in biological applications

Cited by 8 publications

References 9 publications

New Trends in Fluorescent Nanomaterials-Based Bio/Chemical Sensors for Neurohormones Detection─A Review

New Trends in Fluorescent Nanomaterials-Based Bio/Chemical Sensors for Neurohormones Detection─A Review

Optical biosensor with poly[N-nonyl-3,6-bis(ethylenedioxythiophene)carbazole] matrix for monitoring of phenol derivatives

The Implementation of Fluorescence‐Based Detection in LTCC (Low‐Temperature‐Co‐Fired‐Ceramics) Microfluidic Modules

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