Luckeé renal adenocarcinoma, an anuran neoplasm: Studies at the interface of pathology, virology, and differentiation competence

McKinnell, Robert G.; Carlson, Debra L.

doi:10.1002/(sici)1097-4652(199711)173:2<115::aid-jcp4>3.0.co;2-q

Cited by 26 publications

(9 citation statements)

References 20 publications

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“…Melanomas have been described in axolotls [67], and interestingly, can be induced by regeneration [68]. One notable type of adenocarcinoma, the Lucké tumor, found in Rana pipiens is among the first documented case of a virally-induced tumor in vertebrates [69-71]. …”

Section: Evidence Of Neoplasia In Metazoanmentioning

confidence: 99%

Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates

Robert

2010

Developmental & Comparative Immunology

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Despite intense study in mammals, the different roles played by the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia, and perhaps in metastasis are not fully understood. In this review, I will present evidence of neoplasia and invasive malignancy, as well as tumor immunity in invertebrates and nonmammalian vertebrates. I will also present a comparative and evolutionary view of the complex interactions between neoplasia and the host immune system. Overall, I wish to go beyond the too simplistic dichotomy between invertebrates with innate immunity that are only affected with benign neoplasia and vertebrates with adaptive immunity that are affected by metastatic malignancies or cancer.

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Section: Evidence Of Neoplasia In Metazoanmentioning

confidence: 99%

Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates

Robert

2010

Developmental & Comparative Immunology

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“…The first is the Lucké tumor. This renal adenocarcinoma found in Rana pipiens was the first documented case of a virally-induced tumor (12,13). The second is a series of spontaneous thymic lymphoid tumors that occurred in the African frog Xenopus laevis (14) from which stable tumor lymphoid cell lines were derived.…”

Section: Introductionmentioning

confidence: 96%

Tumorigenesis and anti-tumor immune responses in Xenopus

Goyos

Robert²

2009

Front Biosci

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Despite intense study, the role of the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia remains elusive. We present here a comparative view of the complex interactions between neoplasia and the host immune system. We provide evidence, in the amphibian Xenopus laevis, consistent with an evolutionarily conserved and crucial role of the immune system in controlling neoplasia, which involves a striking variety of anti-tumoral immune effectors including conventional CTLs, classical MHC class Ia unrestricted CTLs (CCU-CTLs) that interact with nonclassical MHC class Ib molecules, CD8 NKT-like cells and NK cells. We also review the tumors found in X. laevis with an emphasis on thymic lymphoid tumors and a rare ovarian dysgerminoma. Finally, we consider the use of X. laevis for in vivo study of tumorigenesis. Given our current knowledge, the experimental systems already established in X. laevis, and the rapid accumulation of genetic resources for the sister species Silurana (Xenopus) tropicalis, it is our conviction that these species provide an ideal alternative to the murine system for studying tumorigenesis and tumor immunity.

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“…Biologic behaviour of a given tumour type may vary among species depending on other aetiological factors. Specific aetiologies have been identified for some amphibian neoplasms such as viruses (McKinnell & Carlson, ), genetic factors (Masahito et al ., ) and environmental contaminants (Stacy & Parker, ), and temperature changes have been shown to inhibit the growth of some tumours (Marlow & Mizell, ; Asashima et al ., ; Zavanella, ). No such underlying aetiologies were detected in the cases reported in this paper, although investigations were limited.…”

Section: Discussionmentioning

confidence: 99%

Four cases of neoplasia in amphibians at two zoological institutions: Alpine newt Ichthyosaura alpestris, Red‐eyed tree frog Agalychnis callidryas, Common frog Rana temporaria and Puerto Rican crested toad Peltophryne lemur

O'Brien

Justice

Beckmann

et al. 2017

International Zoo Yearbook

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Four cases of spontaneous neoplasia in different species of Amphibia at two zoological collections in the United Kingdom (2009–2016) are described: disseminated lymphosarcoma with leukaemia in an Alpine newt Ichthyosaura alpestris, nasal adenocarcinoma in a Red‐eyed tree frog Agalychnis callidryas, pulmonary carcinoma in a Common frog Rana temporaria and cutaneous mast‐cell tumour in a Puerto Rican crested toad Peltophryne lemur. History, and gross and histological findings are presented. In particular, mast‐cell tumours in Anura and respiratory tumours of amphibians have rarely been reported.

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Luckeé renal adenocarcinoma, an anuran neoplasm: Studies at the interface of pathology, virology, and differentiation competence

Cited by 26 publications

References 20 publications

Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates

Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates

Tumorigenesis and anti-tumor immune responses in Xenopus

Four cases of neoplasia in amphibians at two zoological institutions: Alpine newt Ichthyosaura alpestris, Red‐eyed tree frog Agalychnis callidryas, Common frog Rana temporaria and Puerto Rican crested toad Peltophryne lemur

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