Luminescence properties of a nanotheranostics based on a multifunctional Fe3O4/Au/Eu[1-(2-naphthoyl)-3,3,3-trifluoroacetone]3 nanocomposite

Khuyen, Hoang Thi; Hương, Trần Thu; Hương, Nguyễn Thanh; Ha, Vu Thi Thai; Văn, Nguyễn Đức; Nghia, Vu Xuan; Anh, Tran Kim; Minh, Le Quoc

doi:10.1016/j.optmat.2020.110229

Cited by 6 publications

(4 citation statements)

References 18 publications

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“…The optimization of Tb 3+ /Gd 3+ ratio in nanorods for rapid detection of naja atra cobra venom was indicated [31]. The critical review of stochastic optical reconstruction microscopy (STORM), NaYF 4 :Yb 3+ /Er 3+ @silica-TPGS Complexes, for theranostics issued [21,[32][33][34]. The core-shell structured nanoparticles and cathodoluminescent nanoprobes for temperature sensing and cathodoluminescent nanophosphor for electron microscopy could be examined [35,36].…”

Section: Resultsmentioning

confidence: 99%

Optic bionanospherical probe from Gd\(_2\)O\(_3\): Yb, Er upconverting nanosphere and mAb^CD133 antibody for precise imaging label of cancer stem cell NTERA-2

Nguyen

Trong

et al. 2023

Comm. Phys.

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Rare earth photonic nanomaterials are increasingly prominently applied in various fields of biomedicine. Currently, there is greater focus on the investigation to control the size and shape of nanomaterials, including the nanospherical form, which allows for precise labeling by only one nanoparticle. This paper demonstrates, for the first time, the construction of a biological nanospherical probe (BNSP) Gd2O3: Yb3+, Er3+/Silica/NH/mAb^CD133 for diagnostic labeling of cancer stem cells (CSCs) NTERA-2. The BNSP was constructed using highly monodisperse spheres with around 200nm uniform size of Gd2O3: 7.6% Yb3+, 1.6% Er3+. They were functionalized by an amine group-contained shell coating and conjugated with CD133 monoclonal antibody. The functionalized nanosphere Gd2O3: Yb, Er/silica/NH2 showed strong upconversion luminescence in red color upon laser excitation in the near-infrared region at 975 nm. The Gd2O3: Yb3+, Er3+/silica/NH2 was carefully implemented to conjugate mAb^CD133 via a linker, glutaraldehyde, to obtain the predictable probe Gd2O3: Yb3+, Er3+/Silica/NH/mAb^CD133. Then, this BNSP was tested in vitro for its capacity to label NTERA-2 cancer stem cells. The efficient labeling based on the fluorescent immunoassay method was detected by incorporating a nanophotometer, Field Energy Scan Electron Microscopy (FESEM), and precisely determined by fluorescent microscopy. The study shows that the BNSP is highly efficient with targeting capacity and specificity in the labeling of cancer stem cells. These advanced results open up promising avenues for the development of precise imaging diagnostics in cancer cellular biomedicine, and beyond.

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Section: Resultsmentioning

confidence: 99%

Optic bionanospherical probe from Gd\(_2\)O\(_3\): Yb, Er upconverting nanosphere and mAb^CD133 antibody for precise imaging label of cancer stem cell NTERA-2

Nguyen

Trong

et al. 2023

Comm. Phys.

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“…The multifunctional FOASET NC was synthesized by a modified Stober method according to our previous work [ 26 ]. This simple wet chemical synthesis route was carried out at room temperature, enabling efficient control of particle shape and size and being convenient for functionalization and bioconjugation.…”

Section: Methodsmentioning

confidence: 99%

“…Biomedical fluorescence image based on luminescent materials is used to detect viruses and cells as well as estimating their biodistribution in both in-vitro and vivo [ 21 , 22 ]. Some luminescent materials, such as organic dyes, semiconductor quantum dots (QDs), and luminescent materials containing rare earth ions, have been extensively studied [ 14 , 23 , 24 , 25 , 26 ]. Several organic dyes have been commercialized to identify ions or molecules associated with viruses and cells.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Multifunctional Eu(III) Complex Doped Fe3O4/Au Nanocomposite for Dual Photo-Magnetic Hyperthermia and Fluorescence Bioimaging

et al. 2023

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In this paper, the luminescent complex Eu(3-thenoyltrifluoroacetonate)3 was integrated with Fe3O4 and gold (Au) nanoparticles to form a multifunctional nanocomposite, Fe3O4/Au/Eu(TTA)3 (FOASET NC), for dual magnetic-photothermal therapy and biomedical imaging. Upon functionalization with amine-NH2, the FOASET NC exhibits a small size of 60–70 nm and strong, sharp emission at λmax = 614 nm, enhanced by surface plasmon resonance (SPR) of Au nanoparticles that provided an effective label for HT29 colorectal cancer cells by fluorescence microscopy imaging. In addition, a hyperthermia temperature (42–46 °C) was completely achieved by using these FOASET NCs in an aqueous solution with three heating modes for (i) Magnetic therapy (MT), (ii) Photothermal therapy (PT), and (iii) Dual magnetic-photothermal therapy (MPT). The heating efficiency was improved in the dual magnetic-photothermal heating mode.

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“…Khuyen et al studied the luminescence properties of a nanotheranostics based on a multifunctional Fe 3 O 4 /Au/Eu[1-(2-naphthoyl)-3,3,3-trifluoroacetone] 3 nanocomposite, combining multiple metal elements. 252 The nanoparticles can be used for hyperthermia and photothermia therapy due to increase in temperature upon laser excitation. Europium is a rare earth element which can be used for providing strong emission of red light, with biocompatibility and luminescent properties for biomedical imaging.…”

Section: Metal-based Nanoparticles Used For Cancer Theranosticsmentioning

confidence: 99%

Review on Metal-Based Theranostic Nanoparticles for Cancer Therapy and Imaging

Fernandes

2023

Technol Cancer Res Treat

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Theranostic agents are promising due to their ability to diagnose, treat and monitor different types of cancer using a variety of imaging modalities. The advantage specifically of nanoparticles is that they can accumulate easily at the tumor site due to the large gaps in blood vessels near tumors. Such high concentration of theranostic agents at the target site can lead to enhancement in both imaging and therapy. This article provides an overview of nanoparticles that have been used for cancer theranostics, and the different imaging, treatment options and signaling pathways that are important when using nanoparticles for cancer theranostics. In particular, nanoparticles made of metal elements are emphasized due to their wide applications in cancer theranostics. One important aspect discussed is the ability to combine different types of metals in one nanoplatform for use as multimodal imaging and therapeutic agents for cancer.

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Luminescence properties of a nanotheranostics based on a multifunctional Fe3O4/Au/Eu[1-(2-naphthoyl)-3,3,3-trifluoroacetone]3 nanocomposite

Cited by 6 publications

References 18 publications

Optic bionanospherical probe from Gd\(_2\)O\(_3\): Yb, Er upconverting nanosphere and mAb^CD133 antibody for precise imaging label of cancer stem cell NTERA-2

Optic bionanospherical probe from Gd\(_2\)O\(_3\): Yb, Er upconverting nanosphere and mAb^CD133 antibody for precise imaging label of cancer stem cell NTERA-2

Synthesis of Multifunctional Eu(III) Complex Doped Fe3O4/Au Nanocomposite for Dual Photo-Magnetic Hyperthermia and Fluorescence Bioimaging

Review on Metal-Based Theranostic Nanoparticles for Cancer Therapy and Imaging

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