Luminescent drug-containing hydrotalcite-like compound as a drug carrier

Chen, Hong; Ling, Qidan; Wen-gong, Zhang; Lin, Zhenghua

doi:10.1016/j.cej.2011.12.096

Cited by 7 publications

(1 citation statement)

References 49 publications

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“…The removed medium was centrifuged three times to ensure removal of all the LTbH nanohybrid particles and then analyzed by the established HPLC method. Calculation of the corrected concentration of the released aspirin is based on the equation: [36] C…”

Section: Luminescence Of Asa-ltbh Compositesmentioning

confidence: 99%

Biohybrid based on layered terbium hydroxide and applications as drug carrier and biological fluorescence probe

2017

Applied Organom Chemis

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Aspirin (abbr. ASA) is intercalated into the layered terbium hydroxide (LTbH) by anion exchange method. Structure, chemical compositions, thermostability, morphology, luminescence property, cytotoxic effects and controlled-release behaviors have been investigated. The ASA molecules may embed between layers with monolayered vertical arrangement, and the thermal stability of organics was enhanced after intercalation. The Tb 3+ luminescence in ASA-LTbH composites was enhanced compared with LTbH precusor and the luminescence intensity increased with the deprotonation degree. The cytotoxic effect of LTbH was observed with a sulforhodamine B (SRB) colorimetric assay, which revealed that the LTbH showed low cytotoxic effects. In addition, the ASA-LTbH composites exhibited a sustained release of ASA in Na 2 HPO 4 -NaH 2 PO 4 buffer solution at pH 6.86 and 37°C. Construction of LRHs composites with drug molecules provided a beneficial pathway for preparing biohybrid based on LRHs, which may have potential applications in drug delivery carrier and biological fluorescence probe.

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Section: Luminescence Of Asa-ltbh Compositesmentioning

confidence: 99%