2006
DOI: 10.1007/430_2006_040
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Luminescent Transition Metal Complexes as Biological Labels and Probes

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Cited by 41 publications
(14 citation statements)
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“…Luminescent transition metal complexes have received increasing attention in photochemistry, organic optoelectronics and luminescent sensors ( 26–33 ). We previously developed oligonucleotide-based, label-free detection methods for nanomolar quantities of Hg 2+ and Ag + ions by employing luminescent platinum(II) metallointercalators ( 34 , 35 ), as well as for assaying exonuclease activity by using crystal violet as a G-quadruplex probe ( 36 ).…”
Section: Introductionmentioning
confidence: 99%
“…Luminescent transition metal complexes have received increasing attention in photochemistry, organic optoelectronics and luminescent sensors ( 26–33 ). We previously developed oligonucleotide-based, label-free detection methods for nanomolar quantities of Hg 2+ and Ag + ions by employing luminescent platinum(II) metallointercalators ( 34 , 35 ), as well as for assaying exonuclease activity by using crystal violet as a G-quadruplex probe ( 36 ).…”
Section: Introductionmentioning
confidence: 99%
“…The binding interactions between metal complexes and nucleic acids have been the subject of numerous studies in recent decades 1 2 3 4 . These interactions are likely to lead to therapeutic (for example, anti-cancer) effects and/or be used for diagnostic (for example, luminescent probes) purposes 5 6 7 8 9 10 11 . To date, the selective targeting of nucleic acids in cancer cells by chemotherapeutic metal complexes in a manner that minimizes off-target bindings and hence diminishes side effects remains a great challenge 12 13 .…”
mentioning
confidence: 99%
“…Another possible reason is that, the self-quenching effect of the complexes became less significant after the biological binding. In the presence of BSA, complexes 1b and 2b showed bi-exponential decay, which is not uncommon for biomolecules labeled with luminescent transition metal complexes [43,44]. The binding constants (K a ) and stoichiometries (n) have been determined using the Scatchard equation and the data are summarized in Table 5.…”
Section: Complexmentioning
confidence: 99%