Luminophore and Magnetic Multicore Nanoassemblies for Dual-Mode MRI and Fluorescence Imaging

Abstract

Nanoassemblies encompass a large variety of systems (organic, crystalline, amorphous and porous). The nanometric size enables these systems to interact with biological entities and cellular organelles of similar dimensions (proteins, cells, …). Over the past 20 years, the exploitation of their singular properties as contrast agents has led to the improvement of medical imaging. The use of nanoprobes also allows the combination of several active units within the same nanostructure, paving the way to multi-imaging. Thus, the nano-object provides various additional information which helps simplify the number of clinical procedures required. In this review, we are interested in the combination between fluorescent units and magnetic nanoparticles to perform dual-mode magnetic resonance imaging (MRI) and fluorescent imaging. The effect of magnetic interaction in multicore iron oxide nanoparticles on the MRI contrast agent properties is highlighted.

Recent Advances in Multimodal Molecular Imaging of Cancer Mediated by Hybrid Magnetic Nanoparticles

“…In addition to widely used chemical fluorochromes, the association of quantum dots (QDs) with magnetic nanoparticles has been shown to enhance their fluorescence due to their high photostability, high extinction coefficients, and excellent absorption properties [ 74 , 75 , 76 ]. In general, three methods have been described for the synthesis of these hybrid nanoplatforms that exhibit both magnetic and fluorescent properties: covalent bonding, silica matrix encapsulation, and dispersion in nanoassemblies [ 76 ]. Some representative studies are listed in Table 2 :…”

“…Encapsulation in silica matrix (nanostructures). The incorporation of magnetic nanoparticles and fluorescent moieties into mesoporous silica particles has been carried out to protect the particles and fluorescent molecules from the surrounding medium [ 76 ]. Zhu et al [ 79 ] synthesized mesoporous silica nanoparticles (MSNs) with functionalized amine groups on their surface to create a multifunctional nanoplatform with a near-infrared dye and a contrast agent, Gd-DTPA ( Figure 8 ).…”

From Single-Core Nanoparticles in Ferrofluids to Multi-Core Magnetic Nanocomposites: Assembly Strategies, Structure, and Magnetic Behavior

“…Among these, multi-core composites built up by magnetic nanoparticles embedded in non-magnetic matrices offer a composition, size, and structure dependent, sometimes nonlinear response to a constant or time-varying magnetic field [50][51][52][53][54][55][56]. In this way, a large variety of carefully engineered magnetoresponsive particles manufactured over time proved to be highly promising for nanomedicine, magnetic cell sorting, magnetic separations in biotechnology and environment purification, actuation, or catalysis [47,[57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74].…”

Development of fluorescence/MR dual-modal manganese-nitrogen-doped carbon nanosheets as an efficient contrast agent for targeted ovarian carcinoma imaging

“…Fluorescence imaging, as a functional imaging method, could compensate the limitation of MR imaging for its high sensitivity in cellular and subcellular levels [10][11][12]. Therefore, the combination of MRI and FL imaging renders a promising dual-modal imaging technique with complementary characteristics to improve the accuracy of tumor diagnosis [11][12][13].…”