Lung and other cancer site mortality in a cohort of Italian cotton mill workers

Mastrangelo, Giuseppe; Fadda, Emanuela; Rylander, Ragnar; Milan, Giovanni; Fedeli, Ugo; Schio, Rossi di; Lange, John H.

doi:10.1136/oem.2007.036327

Cited by 23 publications

(26 citation statements)

References 20 publications

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“…In addition to farmers and gardeners, fishermen appear to some extent to be protected against cancers [30]. Cotton textile workers are less likely to develop lung cancers as compared to the general populations [31], and one study suggests that this may also be the case for sewage plant workers [32]. A study on all economically active Finns identified in a population census in 1970, followed for 30 million-person years, revealed that heavy exposure to moulds and bacteria in the working environment was associated with reduced lung cancer risk among men [33].…”

Section: Microbes and Cancermentioning

confidence: 96%

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Microbial deprivation, inflammation and cancer

Hertzen

Joensuu

Haahtela

2011

Cancer Metastasis Rev

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Dysregulated immune function is involved in the pathogenesis of many common human diseases. Living in urban, microbe-poor environment may have a profound influence on the immune function and eventually also on carcinogenesis. Unfortunately, few studies have thus far addressed the role of exposure to the environmental microbiota on the risk of cancer. Which mechanisms are broken in individuals prone to develop chronic inflammation in response to exposure that does not cause harm in others? Recent work in immunology has revealed that Th17 cells, a third subset of Th cells, and inflammatory cytokines, particularly IL-23, are closely linked with tumour-associated inflammation. Albeit the precise role of Th17 cells in cancer is still unclear and a matter of debate, accumulating evidence shows that Th17 cells are enriched in a wide range of human tumours, and that these tumour-derived Th17 cells may promote angiogenesis, tumour growth and inflammation. Regulatory T cells, in turn, appear to have counter-regulatory effects on Th17 cells and can inhibit their function. Thus, the regulatory network, induced and strengthened by continuous exposure to environmental microbiota, may play an important role in tumour immunobiology in preventing the establishment of chronic inflammation in its early phases. In addition, the discovery of the Toll-like receptor (TLR) system has brought micro-organisms to new light; continuous signalling via these TLRs and other receptors that sense microbial components is necessary for epithelial cell integrity, tissue repair, and recovery from injury. In this communication, we summarise the epidemiological data of living in environments with diverse microbial exposures and the risk of cancer, and discuss the related immunological mechanisms, focusing on the links between environmental microbiota, the Th17/IL-23 axis and cancer-associated inflammation.

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Section: Microbes and Cancermentioning

confidence: 96%

“…Accumulating data obtained from several lines of evidence suggest that cancers occur less frequently 1. Among people who are, by occupation, heavily exposed to environmental micro-organisms [25][26][27][28][29][30][31][32][33] 2. Among populations that adhere to a traditional lifestyle [34] 3.…”

Section: Microbes and Cancermentioning

confidence: 99%

Microbial deprivation, inflammation and cancer

Hertzen

Joensuu

Haahtela

2011

Cancer Metastasis Rev

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“…They permit to suppose that the lower risk of cancer among people working in environments polluted with bacterial endotoxin versus the general population (18,19), different levels of malignancies in humans working in the same carcinogenic conditions (20) and cases of spontaneous regression of cancer (21,22) are dependent on the level of IgMNAE in a person's blood. The low IgMNAE level in the blood may be an endogenous indicator of a high risk of cancer.…”

Section: Discussionmentioning

confidence: 99%

Natural immunity to evolutionary atavistic endotoxin in carcinogenesis induced by chemical agents (a hypothesis)

Moncevičiūtė-Eringienė¹

2012

AML

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A hypothesis of the possibility of natural immunity to evolutionary atavistic endotoxin in chemical carcinogenesis is proposed. Age-dependent stimulation of IgM class natural specific antibodies to the endotoxin of gram-negative bacteria Alcaligenes faecalis 415 (IgMNAE) was confirmed in the blood of normal adult rats. This phenomenon was also revealed in human population. Simultaneously, the suppression and subsequent stimulation of natural immunity to endotoxin under the effect of carcinogenic substances such as benzo(a)pyrene (BP) and metylcholanthrene (MCh) were determined in rats.At first, the primary age-related and the secondary carcinogen-induced enhancement of IgMNAE was explained as the compensatory reactions of the organism's immune system. Later on, within the evolutionary resistance theory of the origin of cancer, based on the general biological laws (resistance to damage and atavism), which was formulated by the author in 2002-2005, another immunological IgMNAE enhancement mechanism was elucidated and explained by the possible activation of the dormant lipopolysaccharide molecules (atavistic endotoxin) alongside evolutionary resistance-related genes and oncogenes according to the inherited programme. All these mechanisms are transmitted from bacteria to mammal cells and possibly have an immense power to drive and control the process of carcinogenesis. It is the activation of these genes and their functions that helps the newly formed tumorous cells to revive the parasitic features in their unlimited division, invasiveness and metastatic growth. Its essence is a specific evolutionary response intended for the survival of damaged cells. Therefore, at present, there is a new oncological strategy problem -production of endotoxin-based vaccines and their application in cancer prophylaxis. IgMNAE can be undoubtedly helpful in elaborating new immunotherapeutic and diagnostic methods.Key words: BP and MCh, evolutionary atavistic and bacterial endotoxin, endotoxin-based vaccines, IgMNAE, resistance to damage, atavism and endogenous parasitism of cancer cells 8 E. Moncevičiūtė-Eringienė

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“…Jis prasiskverbia į organizmą. Mažesnis mirtingumas yra aiškinamas endotoksino apsauginiais mechanizmais aktyvinant imuninius procesus [26][27][28][29][30].…”

Section: įVadasunclassified

“…Atavistinio endotoksino patogenetinį ryšį su navikinio proceso formavimosi mechanizmais parodo ir jau minėti epidemiologiniai darbai su egzogeniu endotoksinu, esančiu medvilnės ir lino pramonės darbininkų ir žemės ūkio darbuotojų aplinkoje [26][27][28][29][30]. Fenomenas, kad žmogaus aplinkoje esantis endotoksinas, patekęs į organizmą, mažina riziką susirgti vėžiu, patvirtina mūsų apibendrinimą apie IgMNAE įtaką onkologinių ligų mažėjimui ir nurodo būtinumą stiprinti žmonių populiacijos natūralų imunitetą atavistiniam endotoksinui.…”

Section: Išvados Ir Pasiūlymaiunclassified

Natūralus imunitetas atavistiniam endotoksinui eksperimentinėje onkologijoje ir žmogaus vėžio profilaktikoje (naujos koncepcijos apžvalga)

Moncevičiūtė-Eringienė¹

2015

Medicinos Teorija Ir Praktika

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saNtraukaReikšminiai žodžiai: vėžys, endotoksinas, imunitetas, profilaktika, koncepcija. Daugiamečiai natūralaus imuniteto endotoksinui tyrimai, pradedant nuo 1970 m., atlikti Vilniaus universiteto Onkologijos instituto Profilaktinės imunologijos laboratorijoje, parodė, kad natūralaus imuniteto funkcijos tiek imunostimuliuotų, tiek imunosupresuotų organizmų yra glaudžiai susijusios su specifiniais IgM klasės natūraliais antikūnais (IgMNA) enterobakteriniam bendram antigenui (EBA), esančiam žarninės grupės mikroorganizmų išorinėje membranoje, t. y. endogeniniai ar spontaniniai antikūnai gram-neigiamos bakterijos Alcaligenes faecalis 415 lipopolysacharido molekulėms, vadinamoms endotoksinu (IgMNAE). Šie duomenys, remiantis mūsų anksčiau sukurtos vėžio kilmės rezistentiškumo teorijos biologiniais dėsniais (rezistentiškumas ir atavizmas), leido pasiūlyti bendrą hipotezę apie "snaudžiančio" atavistinio endotoksino galimą aktyvaciją ir svarų vaidmenį vėžio patologijoje navikinėms ląstelėms tampant savarankiška parazitine populiacija. Hipotezės išvados buvo ekstrapoliuotos į žmogaus vėžio profilaktiką. 1979 ir 1982 m. tirtų 2 223 sveikų žmonių (kraujo donorų ir ne donorų) kraujo serumo IgMNAE duomenys, nustatyti precipitacijos reakcijos agaro gelyje ir autoimunografijos metodais, buvo įvertinti vėžio ligotumo atžvilgiu. Turėję IgMNAE žmonės po 15-30 metų susirgo onkologinėmis ligomis atitinkamai procentine išraiška 1/3 mažiau (5 proc.) negu jų neturėję (p < 0,05). Gauti duomenys leidžia apibendrinti, kad natūralaus imuniteto endotoksinui mechanizme galima įžvelgti organizmo homeostazės apsauginę reakciją. IgMNAE aukštas lygis pagal paveldo programą turėtų stabdyti kancerogenais pažeistų ląstelių evoliucijos eigoje "paslėpto" ląstelės gelmėse ir kancerogenezės procese "atgyjančio" parazitizmo nešėjo atavistinio endotoksino veikos suaktyvėjimą, būtiną vėžinių ląstelių išgyvenimui ir metastazavimui, bet antagonistišką sveikoms kūno ląstelėms. Todėl natūralaus imuniteto endotoksinui stimuliacija pagamintomis vakcinomis prieš atavistinį endotoksiną gali būti naudinga vėžio prevencijoje žmonėms su žemu natūralaus imuniteto lygmeniu ir taip pat kuriant imunoterapinius metodus, siekiant sustabdyti navikinių ląstelių endogeninį parazitizmą. abstract Key words: cancer, endotoxin, immunity, prophylaxis, conception. The many year studies on natural endotoxin immunity since 1970, carried out at Preventive Immunology Laboratory of the Institute of Oncology of Vilnius University has shown that the natural immune functions of both immunostimulated and immunosuppresed organisms are closely related to IgM class natural antibodies (IgMNA) to the enterobacterial common antigen (ECA) from external membranes of intestinal microorganisms, i.e. endogenous or spontaneous antibodies to lipopolysaccharde (endotoxin) of gram-negative bacteria Alcaligenes faecalis 415 (IgMNAE). These data, based on our proposed resistance theory origin of cancer of its biological laws (resistance and atavism) allowed to propose a unified hypothesis of the "drowsin...

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Lung and other cancer site mortality in a cohort of Italian cotton mill workers

Abstract: The results support previous reports that a high and prolonged exposure to cotton dust and other endotoxin-containing organic dusts is related to a lower risk of lung cancer. There was no indication of a reduced risk for other forms of cancer.

Cited by 23 publications

References 20 publications

Microbial deprivation, inflammation and cancer

Microbial deprivation, inflammation and cancer

Natural immunity to evolutionary atavistic endotoxin in carcinogenesis induced by chemical agents (a hypothesis)

Natūralus imunitetas atavistiniam endotoksinui eksperimentinėje onkologijoje ir žmogaus vėžio profilaktikoje (naujos koncepcijos apžvalga)

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