Lung Cancer and Chronic Obstructive Pulmonary Disease: Needs and Opportunities for Integrated Research

Abstract

Lung cancer and chronic obstructive pulmonary disease (COPD) are leading causes of morbidity and mortality in the United States and worldwide. They share a common environmental risk factor in cigarette smoke exposure and a genetic predisposition represented by the incidence of these diseases in only a fraction of smokers. The presence of COPD increases the risk of lung cancer up to 4.5-fold. To investigate commonalities in disease mechanisms and perspectives for disease chemoprevention, the National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer Institute (NCI) held a workshop. The participants identified four research objectives: 1) clarify common epidemiological characteristics of lung cancer and COPD; 2) identify shared genetic and epigenetic risk factors; 3) identify and validate biomarkers, molecular signatures, and imaging-derived measurements of each disease; and 4) determine common and disparate pathogenetic mechanisms. These objectives should be reached via four research approaches: 1) identify, publicize, and enable the evaluation and analysis of existing datasets and repositories of biospecimens; 2) obtain phenotypic and outcome data and biospecimens from large studies of subjects with and/or at risk for COPD and lung cancer; 3) develop and use animal and other preclinical models to investigate pathogenetic links between the diseases; and 4) conduct early-phase clinical trials of potential chemopreventive agents. To foster much needed research interactions, two final recommendations were made by the participants: 1) incorporate baseline phenotyping and outcome measures for both diseases in future longitudinal studies of each disease and 2) expand collaborative efforts between the NCI and NHLBI.

Worse Prognosis for Stage IA Lung Cancer Patients with Smoking History and More Severe Chronic Obstructive Pulmonary Disease

“…Lung cancers that arise from the lung parenchyma with abnormal and excessive inflammatory responses in COPD are thought to have an aggressive character. 26) Also, COPD often coexists with diseases such as cachexia, cardiovascular disease, osteoporosis and diabetes, which are all associated with systemic inflammation, 27) and such comorbidities might directly or indirectly affect prognosis. Determination of the basis of the association of GOLD 2/3 COPD with a worse prognosis may lead to better treatment and outcomes.…”

An Experimental Model for Induction of Lung Cancer in Rats by Chlamydia Pneumoniae

“…Boelens et al (2011) reported that a relationship exists between squamous cell lung cancer and COPD. Punturieri et al (2009) reported that the presence of COPD increases the risk of lung cancer by up to 4.5-fold. However, the mechanisms by which Cpn chronic infection induces lung cancer remain unclear.…”

The Effect of Sampling Technique on Bacteriological Results in Patients With Malignant Lung Tumors

“…По данным литературы, в 50-90% случаев рак легкого сочетается с хронической обструктивной болезнью легких, которая, как правило, ассоциирована с инфекцией в дыха-тельных путях, и протекает особенно тяжело [23,25,26]. Противоопухолевое лечение этой категории больных про-ходит с более частым развитием инфекционных осложне-ний в нижних дыхательных путях [12,15,23,25,26].…”

“…Противоопухолевое лечение этой категории больных про-ходит с более частым развитием инфекционных осложне-ний в нижних дыхательных путях [12,15,23,25,26].…”