Lung cancer and exposure to arsenic in rural Bangladesh

Mostafa, Mohammad Golam; McDonald, Jane; Cherry, Nicola

doi:10.1136/oem.2007.037895

Cited by 71 publications

(65 citation statements)

References 8 publications

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“…Possible reasons for this difference are that all cohort subjects had occupational radon and arsenic exposure history, and most were male and smokers. Lung cancer cases in other studies conducted in radon or arsenic exposed populations show a similar histological distribution [21,22]. Animal experimental studies have also shown that most lung cancer among rats which inhaled radon was squamous carcinoma [23].…”

Section: Discussionmentioning

confidence: 94%

Prior lung disease and lung cancer risk in an occupational-based cohort in Yunnan, China

et al. 2011

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Section: Discussionmentioning

confidence: 94%

Prior lung disease and lung cancer risk in an occupational-based cohort in Yunnan, China

et al. 2011

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“…Increased exposure of arsenic concomitantly increased the susceptibility of lung cancer both in smokers and non-smokers (Järup and Pershagen, 1991). For the most part, smoking cigarettes prominently increased the risk of lung cancer (Chen et al, 2004;Mostafa et al, 2008). However, a recent study showed no such interaction between smoking and arsenic induced lung cancer (Heck et al, 2009).…”

Section: Lungsmentioning

confidence: 94%

“…Moreover, dose and duration of arsenic exposure critically influences growth retardation and fetal death (Golub et al, 1998;Tabocova et al, 1996). 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 (Cherry et al, 2008). In an arsenic endemic area at Northeastern Taiwan has shown an association between drinking well water with arsenic contamination (range 0.15−3585µg/L) and preterm delivery (although not significant) along with low birth weight (Yang et al, 2003).…”

Section: Effects Of Arsenic On Reproductive System and Developmentmentioning

confidence: 95%

Arsenic and human health effects: A review

Abdul

Jayasinghe

Chandana

et al. 2015

Environmental Toxicology and Pharmacology

734

153

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“…Among patients referred for a lung biopsy in Bangladesh, those diagnosed with malignant lung tumors had higher well water arsenic concentrations than those diagnosed with benign conditions (e.g. inflammatory or tubular disease), but only among smokers (Mostafa et al, 2008), while the ORs were only statistically significant for arsenic above 100 μg/L compared to less than 10 μg/L (OR = 1.65; 95 % CI = 1.25-1.68 for smokers only), there was evidence of a dose-related increase. A limitation of this study is the reliance on patients with suspicious lung lesions on chest x-ray as controls (i.e.…”

Section: Lung Cancermentioning

confidence: 99%

Scientific Opinion on Arsenic in Food

2009

EFSA Journal

879

220

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The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) assessed the risks to human health related to the presence of arsenic in food. More than 100,000 occurrence data on arsenic in food were considered with approximately 98 % reported as total arsenic. Making a number of assumptions for the contribution of inorganic arsenic to total arsenic, the inorganic arsenic exposure from food and water across 19 European countries, using lower bound and upper bound concentrations, has been estimated to range from 0.13 to 0.56 µg/kg bodyweight (b.w.) per day for average consumers, and from 0.37 to 1.22 µg/kg b.w. per day for 95 th percentile consumers. Dietary exposure to inorganic arsenic for children under three years of age is in general estimated to be from 2 to 3-fold that of adults. The CONTAM Panel concluded that the provisional tolerable weekly intake (PTWI) of 15 µg/kg b.w. established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) is no longer appropriate as data had shown that inorganic arsenic causes cancer of the lung and urinary bladder in addition to skin, and that a range of adverse effects had been reported at exposures lower than those reviewed by the JECFA. The CONTAM Panel modelled the dose-response data from key for providing consumption information and calculating exposure, the partners of the EFSA project on the "Individual food consumption data and exposure" coordinated by Ghent University (Department of Public Health, University Hospital, Ghent University, Belgium), and RIKILT (Institute of Food Safety, Wageningen, The Netherlands) for the accessibility of the exposure assessment tools. 4 Table of contents shows now the fourth level of subheadings. 5 An error in the interpretation of the total number of the population in the study of Rahman et al. (2006a) was discovered (Table 41). The BMDL was recalculated and as a consequence it was not considered a potential reference point. The text in the opinion, Table 43 and Appendix were revised accordingly. In addition, the header of the "total number of cases" was replaced by "total number of individuals" in Tables 40-42 and the erroneous units were corrected to µg/L in the text below SUMMARYArsenic is a metalloid that occurs in different inorganic and organic forms, which are found in the environment both from natural occurrence and from anthropogenic activity. The inorganic forms of arsenic are more toxic as compared to the organic arsenic but so far most of the occurrence data in food collected in the framework of official food control are still reported as total arsenic without differentiating the various arsenic species. The need for speciation data is evident because several investigations have shown that especially in seafood most of the arsenic is present in organic forms that are less toxic. Consequently, a risk assessment not taking into account the different species but considering total arsenic as being present exclusively as inorganic arsenic would lead to a considerable overestimation of the health risk rel...

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Lung cancer and exposure to arsenic in rural Bangladesh

Cited by 71 publications

References 8 publications

Prior lung disease and lung cancer risk in an occupational-based cohort in Yunnan, China

Prior lung disease and lung cancer risk in an occupational-based cohort in Yunnan, China

Arsenic and human health effects: A review

Scientific Opinion on Arsenic in Food

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