Lung cancer as a complication of prolonged survival in patients with lymphoma

Konits, Philip H.; Aisner, Joseph; Whitacre, Margaret; Wiernik, Peter H.

doi:10.1002/mpo.2950100403

Cited by 18 publications

(2 citation statements)

References 33 publications

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“…There have been reports of a positive correlation between a history of smoking and the development of lung cancer after malignant lymphoma (6,7), and, since our patient was a heavy smoker, his habit probably played a role in the development of the lung cancers. Although he had been treated with radiation, his lung cancers were outside the radiation area, so there was little likelihood of a causal relationship between radiation and the lung cancers.…”

Section: Case Reportmentioning

confidence: 54%

Synchronous Triple Lung Cancers after Treatment for Non-Hodgkin's Lymphoma: Metachronous Quadruple Cancers

et al. 2003

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After chemotherapy and radiotherapy for nonHodgkin's lymphoma during a one-year period, a 66-year-old mandeveloped synchronous triple lung cancers in both lungs. Of the three resected tumors, one was advanced large cell carcinoma with neuroendocrine morphology, and the other two were early squamouscell carcinoma without lymph node metastasis. Although he received repeated chemotherapy for lung cancer, the patient died of hepatic failure due to multiple liver metastases. Autopsy revealed disseminated metastasis of the large cell carcinoma with neuroendocrine morphology throughout the entire body, but no recurrence of malignant lymphoma or squamouscell carcinoma was found. To our knowledge, this is the first report of triple lung cancers occurring after treatment for malignant lymphoma.

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Section: Case Reportmentioning

confidence: 54%

Synchronous Triple Lung Cancers after Treatment for Non-Hodgkin's Lymphoma: Metachronous Quadruple Cancers

et al. 2003

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“…Others have noted no increase in the occurrence of lung cancer in patients treated for NHL (Greene et al, 1978), and no increase was defined in the present study (RR = 1.4, CI 0.9-1.2, p = 0.1). A positive correlation between history of cigarette smoking and development of lung cancer in patients with NHL has been noted (Libshitz et al, 1978;Konits et al, 1982).…”

Section: Discussionmentioning

confidence: 99%

Second malignant neoplasms in patients with non hodgkin's lymphoma

Lishner

Slingerland

Barr

et al. 1991

Hematological Oncology

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A retrospective review of the records of 3886 patients with non-Hodgkin's lymphoma registered at the Princess Margaret Hospital between 1970 and 1985 was undertaken to determine the incidence of second malignant tumours. Three thousand and twenty-one patients with a minimum documented follow-up of 6 months from referral were identified for analysis. The overall observed/expected ratio for all cancers in patients with malignant lymphoma was 1, suggesting no increased risk of developing a second malignant neoplasm compared to the general population. When the data were analyzed independently for each tumour site, statistically significant increased risk of developing acute non lymphocytic leukemia (ANLL) (p less than 0.001) and carcinoma of the tongue (p less than 0.05) were found. An increased risk of lung cancer following lymphoma was detected but was not statistically significant. Survival following diagnosis of ANLL and lung cancer was similar and significantly shorter than that following the diagnosis of other second malignancies. The risk of developing a second primary cancer was significantly related to increasing patient age.

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Risk of second malignancy after cutaneous T-cell lymphoma

Kantor

Curtis

Vonderheid

et al. 1989

Cancer

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Risk of second primary malignancy was assessed in a population-based follow-up survey of all persons who developed cutaneous T-cell lymphoma (CI'CL) in nine geographic areas of the United States covered by the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute during the period 1973 to 1983. Among 544 patients with a first primary tumor reported as CI'CL, a second cancer developed in 35 (6%), yielding a significantly elevated relative risk (RR) of 1.7, which reflects excesses for cancers of the lung and colon and non-Hodgkin's lymphoma. Although the excess of lymphoma may be related to the evolution of CI'CL to less differentiated T-cell lymphoma, additional studies are needed to clarify the immunologic, genetic, viral, and environmental factors that may contribute to the development of second cancers. Cancer 63:1612-1615, 1989. YCOSIS FUNGOIDES and Sezary syndrome, collec-M tively termed cutaneous T-cell lymphoma (CTCL),are uncommon neoplasms characterized by malignant proliferation of T-lymphocytes in the skin. Altered immune response in CTCL, particularly with more advanced disease,' in addition to the effects of radiation, alkylating agents, and PUVA suggest that CTCL patients may be at increased risk of second primary malignancy. A recent follow-up of 63 patients with CTCL revealed a 2.4-fold excess of subsequent malignancy of diverse sites compared to general population rates.' Various second neoplasms after CTCL have been reported in clinical series,*-" but the patterns and determinants are not yet clear.Evaluation of second malignancy risk after CTCL has been difficult due to small numbers of patients usually available for study. Therefore, the current report analyzes the incidence of second primary cancers in a cohort of 544 CTCL patients reported to the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute, which has documented and followed since 1973 all newly diagnosed cases of cancer in selected states and metropolitan areas covering approximately 10% of the US population.

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Lung cancer as a complication of prolonged survival in patients with lymphoma

Cited by 18 publications

References 33 publications

Synchronous Triple Lung Cancers after Treatment for Non-Hodgkin's Lymphoma: Metachronous Quadruple Cancers

Synchronous Triple Lung Cancers after Treatment for Non-Hodgkin's Lymphoma: Metachronous Quadruple Cancers

Second malignant neoplasms in patients with non hodgkin's lymphoma

Risk of second malignancy after cutaneous T-cell lymphoma

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