Lung cancer correlates in Lebanese adults: A pilot case–control study

Aoun, Jawad; Saleh, Nadine; Waked, Mirna; Salamé, Joseph; Salameh, Pascale

doi:10.1016/j.jegh.2013.06.005

Cited by 33 publications

(25 citation statements)

References 36 publications

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“…Nevertheless, the chemical composition of waterpipe smoke, which seems to contain toxicants in quantities similar or even higher than cigarette smoke, may give biological plausibility for the associations we found [32][33][34][35][36]. Moreover, waterpipe active smoking was shown to be a cause of several respiratory diseases and cancers [37][38][39]. schools (OR = 1.67; p < 0.001), higher age categories (p < 0.001), male sex (OR = 1.36; p < 0.001), and a father and a mother's lower education (p < 0.001) were associated with higher odds of probable asthma, defined as physician diagnosed asthma or asthma symptoms (all wheezing) ( Table 1).…”

Section: Discussionmentioning

confidence: 95%

Maternal waterpipe smoke exposure and the risk of asthma and allergic diseases in childhood: A post hoc analysis

Waked

Salameh

2015

Int J Occup Med Environ Health

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Objectives: This analysis was conducted with the objective of evaluating association between waterpipe passive smoking exposure and asthma, and allergies among Lebanese children. Material and Methods: Data were taken from a crosssectional study on children from public and private schools. A sample of 22 schools participated in the study, where standardized written core questionnaires were distributed. From 5 to 12-year-old students filled in the questionnaires at home, while 13-14-year-old students filled it in in the class. In total, 5522 children were evaluated for the prevalence of asthma, allergic rhinitis and atopic eczema, and their associated factors, including waterpipe exposure due to parents' smoking. Results: The descriptive results of parental smoking were, as follows: among mothers: 1609 (29%) mothers smoked cigarettes, 385 (7%) smoked waterpipe and 98 (1.8%) smoked both; among fathers: 2449 (44.2%) smoked cigarettes, 573 (10.3%) smoked waterpipe and 197 (3.5%) smoked both. Maternal waterpipe smoking was significantly and moderately associated with allergic diseases (p < 0.001; OR a = 1.71), including probable asthma, rhinitis and dermatitis (p < 0.001 for all). Quite on the opposite, father's waterpipe smoking was not associated with any of the diseases. Parental cigarette smoking demonstrated some positive effects: father's cigarette smoking did not show association with dermatitis or asthma diagnosed by a physician, while mother's cigarette smoking showed a positive association only with probable asthma. Moreover, no interactions between cigarette and waterpipe smoking were observed. Conclusions: Maternal waterpipe smoking should be regarded as a high risk behavior; however, additional studies are necessary to confirm this finding.

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Section: Discussionmentioning

confidence: 95%

Maternal waterpipe smoke exposure and the risk of asthma and allergic diseases in childhood: A post hoc analysis

Waked

Salameh

2015

Int J Occup Med Environ Health

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“…There are numerous epidemiological studies which have associated increased risk of esophageal, head and neck 22 and lung cancer [22][23][24] development with shisha smoking. However, laboratory studies to yield mechanistic insights into shisha mediated molecular alterations have not been carried out.…”

Section: Discussionmentioning

confidence: 99%

Multiomic analysis of oral keratinocytes chronically exposed to shisha

Patil

Patel

Advani

et al. 2019

J Oral Pathology Medicine

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Background Tobacco is smoked in different form including cigarettes and water pipes. One popular form of water pipe smoking especially in Middle Eastern countries is shisha smoking. Shisha has been associated with various diseases including oral cancer. However, genomic alterations and gene expression changes associated with chronic shisha exposure have not been previously investigated. Objectives Whole‐exome sequencing and gene expression profiling of immortalized human oral keratinocytes (OKF6/TERT1) cells chronically treated with 0.5% shisha extract for a period of 8 months was undertaken to characterize molecular alterations associated with shisha exposure. Methods Genomic DNA and RNA were extracted and preprocessed as per manufacturer's instruction and subjected to whole‐exome and transcriptome sequencing using Illumina HiSeq2500 platform. Exome was analyzed using GATK pipeline whereas RNA‐Seq data was analyzed using HiSat2 and HTSeq along with DESeq to elucidate differentially expressed genes. Results Whole‐exome sequence analysis led to identification of 521 somatic missense variants corresponding to 389 genes RNA‐Seq data revealed 247 differentially expressed genes (≥2‐fold, P‐value<0.01) in shisha treated cells compared to parental cells. Pathway analysis of differentially expressed genes revealed that interferon‐signaling pathway was significantly affected. We predict activation of MAPK1 pathway which is known to play a key role in oral cancer. We also observed allele specific expression of mutant LIMA1 based on RNA‐Seq dataset. Conclusion Our findings provide insights into genomic alterations and gene expression pattern associated with oral keratinocytes chronically exposed to shisha.

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“…For some, the combination of the 2 behaviors is more enjoyable than hookah smoking alone. This potential risk for increased hookah smoking comes with the potential for increased risk of negative health outcomes associated with hookah smoking (eg, carbon monoxide poisoning, 36–44 communicable diseases, 45,46 cancer 47–50 ). If hookah smoking continues to gain popularity and becomes available in locations and events where alcohol is typically consumed, the risk for hookah smoking also may increase.…”

Section: Discussionmentioning

confidence: 99%

Hookah and Alcohol Use among Young Adult Hookah Smokers: A Mixed Methods Study

Barnett

et al. 2015

Am J Hlth Behav

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Objectives Hookah tobacco smoking has grown steadily in popularity among young adults in the United States. Little attention has been given to the relationship between hookah smoking and another behavior that is common among young adults – alcohol use. The purpose of this study was to examine hookah and alcohol use among young adults. Methods Forty young adult hookah smokers (55% female) participated in focus group sessions on hookah use beliefs and a brief survey examining hookah and alcohol use including drinking alcohol before, during, or after smoking hookah. Results Quotes from the focus groups indicated that alcohol use may promote hookah use among individuals who have little or no hookah smoking experience. Alcohol use, binge drinking, and alcohol use before, during, and after hookah use were common among the participants regardless of legal drinking age status. Nearly half of the participants preferred to drink alcohol while smoking hookah due to the improved physical and social effects they associated with combining the 2 behaviors. Conclusions For some young adult hookah smokers, alcohol appears to enhance the hookah smoking experience and may play a role in hookah smoking initiation. Future research and interventions should address the association between hookah and alcohol use.

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Lung cancer correlates in Lebanese adults: A pilot case–control study

Abstract: In this pilot study, it was found that in addition to smoking, outdoor and indoor pollution factors were potential risk factors of lung cancer. Additional studies would be necessary to confirm these findings.

Cited by 33 publications

References 36 publications

Maternal waterpipe smoke exposure and the risk of asthma and allergic diseases in childhood: A post hoc analysis

Maternal waterpipe smoke exposure and the risk of asthma and allergic diseases in childhood: A post hoc analysis

Multiomic analysis of oral keratinocytes chronically exposed to shisha

Hookah and Alcohol Use among Young Adult Hookah Smokers: A Mixed Methods Study

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