Lung Cancer: Diagnosis and Treatment Approach

Tantraworasin, Apichat; Suksomboonchroen, Thatthan; Wannasopha, Yutthaphan; Kongkarnka, Sarawut; Saeteng, Somcharoen; Lertprasertsuke, Nirush; Euathrongchit, Juntima; Chewaskulyong, B.

doi:10.1007/978-3-319-21683-6_7

Cited by 3 publications

(3 citation statements)

References 216 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Non‐small‐cell lung cancer (NSCLC) is the most common histological type of lung cancer with an increasing incidence year by year 3,4 . Currently, the therapeutic methods include surgical treatment, chemotherapy, radiotherapy and targeted therapy, and so on 5,6 . However, patients with advanced NSCLC fail to have a response to these conventional therapies, with a poor 5‐year survival rate 7,8 .…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Currently, the therapeutic methods include surgical treatment, chemotherapy, radiotherapy and targeted therapy, and so on. 5,6 However, patients with advanced NSCLC fail to have a response to these conventional therapies, with a poor 5-year survival rate. 7,8 Since the majority of NSCLC patients have no specific clinical manifestations in the early stage, the diagnosis usually begins at the late stage when most patients already presented distant metastasis and local invasion, leading to the tumor-related deaths.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis

Wang

et al. 2023

Environmental Toxicology

View full text Add to dashboard Cite

Dysregulated circWHSC1 has been shown to play potential roles in diverse cancer types, including ovarian cancer, endometrial cancer and hepatocellular carcinoma (HCC). The objective of this study was to investigate its expression, underlying role and regulatory mechanism in non‐small‐cell lung cancer (NSCLC). The expression of circWHSC1 was determined by real‐time PCR. After knockdown of circWHSC1 expression in NSCLC cells, the proliferation, migration, and invasion were detected using CCK‐8, colony formation, and Transwell assays, and the effects of circWHSC1 on NSCLC tumorigenesis in vivo was also investigated. With the help of luciferase reporter and pull‐down assays, we further explored the downstream mechanism of circWHSC1 in NSCLC cells. CircWHSC1 was highly expressed in NSCLC tissues and cell lines. The inhibition of circWHSC1 suppressed the malignant properties of NSCLC cells, as evidenced by the reduction of proliferation, migration and invasion. CircWHSC1 sponged miR‐590‐5p and functioned as an oncogene in NSCLC by increasing sex determining region Y‐boxprotein 5 (SOX5) expression. CircWHSC1 may contribute to the oncogenicity of NSCLC via the regulation of miR‐590‐5p/SOX5 axis, which might be a novel therapeutic target in NSCLC.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis

Wang

et al. 2023

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…1 At present, the conventional methods for the treatment of lung cancer include surgical treatment, chemotherapy, radiotherapy and targeted therapy, and so on. 2 However, patients with advanced tumors fail to have a response to the conventional therapy, with a 5-year survival rate of less than 15%. 3 Since the majority of lung cancer patients have no specific clinical manifestations in the early stage, the diagnosis usually begins at the middle and late stage when most patients already presented metastasis and local invasion.…”

Section: Introductionmentioning

confidence: 99%

LncRNA LINC00115 facilitates lung cancer progression through miR‐607/ITGB1 pathway

Xue

Lin

et al. 2021

Environmental Toxicology

View full text Add to dashboard Cite

Dysregulated long noncoding RNAs (lncRNAs) have potential roles in various cancer types. The objective of this study was to investigate the expression and the underlying role of long intergenic nonprotein coding RNA 115 (LINC00115) in lung cancer. The relative expression of LINC00115 and miR-607 in tumor tissues and cells was detected by real-time PCR. After overexpression or knockdown of LINC00115 expression in tumor cells, the changes in the proliferation, migration, and invasion capacities were detected via Counting Kit-8 (CCK-8) assay and transwell assays. The interplay among LINC00115, miR-607, and integrin β1 (ITGB1) was confirmed by bioinformatics analyses and luciferase reporter assay. In addition, tumor cells with LINC00115 knockdown were injected into nude mice to investigate the effect of LINC00115 on tumorigenesis in vivo. LINC00115 was highly expressed in tumor tissues and cells. LINC00115 promoted the malignant properties of tumor cells. Investigation to its molecular mechanism revealed that LINC00115 functioned as a competitive endogenous RNA (ceRNA), regulating the expression of ITGB1 by sponging miR-607 to affect tumor growth. The LINC00115/miR-607/ITGB1 signaling axis might be a novel therapeutic target in lung cancer.

show abstract

Smart Lung Cancer Detector Using a Novel Hybrid for Early Detection of Lung Cancer

Tumuluru

Raju

Santhi

et al. 2022

Lecture Notes in Networks and Systems

View full text Add to dashboard Cite

Lung Cancer: Diagnosis and Treatment Approach

Cited by 3 publications

References 216 publications

CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis

CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non‐small‐cell lung cancer via miR‐590‐5p/SOX5 axis

LncRNA LINC00115 facilitates lung cancer progression through miR‐607/ITGB1 pathway

Smart Lung Cancer Detector Using a Novel Hybrid for Early Detection of Lung Cancer

Contact Info

Product

Resources

About