Lung Cancer in Pakistan

Sheikh, H.; Munawar, Kiran; Sheikh, Fareeha; Qamar, Muhammad Fawad Ul

doi:10.1016/j.jtho.2022.01.009

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…Lung cancer in Pakistan is a significant health concern, and efforts to reduce its prevalence involve addressing risk factors, implementing preventive measures, and improving access to early detection (Sheikh et al, 2022). From the above results and data accrued, several things can be highlighted.…”

Section: Discussionmentioning

confidence: 99%

Lung Cancer: Epidemiology and Treatment Paradigms in a Single Center From Pakistan

BANO,

ZAFAR,

NADEEM

et al. 2023

Biol Clin Sci Res J

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Lung cancer is the second most common cancer worldwide and the leading cancer in men, with women following closely behind as the second most affected group. In 2020, there were more than 2.2 million new reported cases of lung cancer. According to Globocan, it is the third most common cancer in Pakistan, with an incidence rate of 5.9% in 2018 and a mortality rate of 7.8%. This study aims to explore the epidemiology, risk factors, and outcomes associated with lung cancer in Pakistan. The study is a retrospective observational investigation conducted at Jinnah Hospital in Lahore. The data of 50 adult patients who were diagnosed with biopsy-proven lung carcinoma, aged 20 years or older, and had received at least four cycles of first-line therapy were collected from their files. Patients were enrolled at random, regardless of gender. The results showed that 80% of the patients were male, while only 20% were female. The majority of the patients, 58%, had a history of smoking, with males accounting for 50% of this group. At presentation, 78% of the patients had stage 4 disease, and 68% received platinum with paclitaxel upfront. Forty-eight percent of the patients were above 60 years of age. Squamous cell and adenocarcinoma lung were the most common types of lung cancer, accounting for 34% and 30% of cases, respectively. After four cycles of first-line therapy, 30% of patients showed a partial response, while 56% continued with second-line treatment. In conclusion, lung cancer is a significant health concern in Pakistan, and measures are needed to decrease its incidence. Further studies with larger sample sizes are required to understand better the prevalence and effectiveness of treatment paradigms for lung cancer in Pakistan.

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Section: Discussionmentioning

confidence: 99%

Lung Cancer: Epidemiology and Treatment Paradigms in a Single Center From Pakistan

BANO,

ZAFAR,

NADEEM

et al. 2023

Biol Clin Sci Res J

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“…Adenocarcinoma and squamous cell carcinoma are the two primary histopathologic subtypes of nonsmall cell lung cancer (NSCLC), which makes up about 85% of all lung malignancies [2]. The prevalence and mortality of lung cancer in Pakistan are unknown due to the lack of a population-based cancer registry and the conflicting incidence figures [3]. Low-dose CT (LDCT) is currently the gold standard for screening for lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Early detection of lung adenocarcinoma on CT scan

AYESHA BUKHARI,

Juan Yao,

Izhar ud din

2024

World J. Bio. Pharm. Health Sci.

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Background: Lung cancer is the most common human malignancy and the principal cause of cancer-related death worldwide. Nowadays, adenocarcinoma is the most common histologic form, making up over half of all cases Objective: To determine the early detection of lung adenocarcinoma on CT scan Methods: A cross-sectional study was conducted at Jinnah Hospital Lahore Pakistan, which was performed between September 2020 to October 2023, The name of CT scan machine which was used in our study was Toshiba 64 slice and its slice thickness was 0.5 mm. Iodine based contrast is used. The total number of patients in our study were 150. The number of Male patients were 61 and female were 89. For all patients, we did diagnostic tests CT test . BMI parameter of every patients we took. We also took detailed history from the patients about the signs and symptoms. We did both the Lung window and the Mediastinal window. Data was tabulated and analyzed by SPSS version 26. Result: In a current study total 150 patients were enrolled. The minimum age of patients were 43 years and the maximum age of the patients were 77 years. The mean age were 59.60±7.877 years. The minimum BMI of patients were 26 (Kg/m2) and the maximum BMI were 34 (Kg/m2). The mean BMI were 28.55±3.740 (Kg/m2). The minimum size of the Lung Adenocarcinoma of patients were 0.3 cm and the maximum size of Lung Adenocarcinoma of patients were 2.8 cm. The mean size of the lung adenocarcinoma were 1.413±0.627 cm. The stage of lung adenocarcinoma in the age group of 41-50 years 1A1 were 8, 1A2 were 7 and 1A3 were 2 . The total patients with age 41-50 years were 17. The stage of lung adenocarcinoma in the age group of 51-65 years 1A1 were 34, 1A2 were 47 and 1A3 were 19. The total patients with age 51-65 years were 99. The stage of lung adenocarcinoma in the age group of >66 years 1A1 were 6, 1A2 were 11 and 1A3 were 17. The total patients with age >66 years were 34. P-value of stages of lung adenocarcinoma in age group was 0.03. The stage of lung adenocarcinoma 1A1 in male patients were 17 and female were 31. The stage of lung adenocarcinoma 1A2 in male patients were 28 and female were 36. The stage of lung adenocarcinoma 1A3 in male patients were 16 and female were 22. Total male patients were 61 and females were 89.P-value of stages of lung adenocarcinoma in gender was 0.04. Conclusion: We concluded that routine CT examination could detect more lung cancer at an early stage, especially adenocarcinoma, and detect patients with less aggressive features. The main advantage of the CT scan is, its non-invasive, painless diagnostic test as compared to biopsies. The chance of spreading of cancer cell is reduced. In our study females were more as compared to males.

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“… 2 In Pakistan, approximately 8500 new cases are diagnosed in 2020. 3 NSCLC treatment is stage-specific, and surgical resection is more suitable for patients with stages I or II. However, this approach to early-stage, NSCLC remains complex and unique to the patient.…”

Section: Introductionmentioning

confidence: 99%

Patient Perspectives and Side-Effects Experience on Chemotherapy of Non-Small Cell Lung Cancer: A Qualitative Study

Zubair¹,

Khan²,

Gulzar³

et al. 2023

CMAR

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Purpose This study aimed to explore patients’ experiences of palliative chemotherapy for non-small cell lung cancer (NSCLC), how patients adapt to their new and challenging life after chemotherapy, their beliefs, and their quality of life. Patients and Methods The study used an exploratory descriptive qualitative approach that was designed to explore the experiences and side effects of NSCLC patients on chemotherapy in Pakistan. The study was designed to obtain a deeper understanding of 22 NSCLC patients’ experiences, using a face-to-face approach and interviews were conducted. Patients who have completed chemotherapy agreed to participate in semi-structured interviews. Results The data were arranged into five themes: hospital facilities and environment, patient’s beliefs in alternative treatments, presenting a positive/negative face, life is for living, and health insurance coverage. The major complaints related to bad experiences of chemotherapy-induced side effects, but these patients still managed to complete the full course of their respective chemotherapy. Additionally, the current study revealed the real experience of patients with NSCLC which had been less studied. The patient’s experience was summarized into four themes and several subthemes. Conclusion This study aid healthcare providers when deciding on treatment options that will improve shared decision-making between clinicians and treatment outcomes.

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Lung Cancer in Pakistan

Cited by 10 publications

References 13 publications

Lung Cancer: Epidemiology and Treatment Paradigms in a Single Center From Pakistan

Lung Cancer: Epidemiology and Treatment Paradigms in a Single Center From Pakistan

Early detection of lung adenocarcinoma on CT scan

Patient Perspectives and Side-Effects Experience on Chemotherapy of Non-Small Cell Lung Cancer: A Qualitative Study

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