Lung Cancer in Patients with Idiopathic Pulmonary Fibrosis.

Nagai, Atsushi; Chiyotani, Atsushi; Nakadate, Toshio; Konno, Kunihiko

doi:10.1620/tjem.167.231

Cited by 100 publications

(95 citation statements)

References 12 publications

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“…In previous literature, IPF-CA was reported to be more frequent in the periphery of the lung and the lower lobe, where the fibrosis was predominant, suggesting a direct relationship [5,6,19]. The peripheral location of the lung cancer was reported as 88% by NAGAI and CHIYOTANI [5], 91% by MIZUSHIMA and KOBAYASHI [2] and 66% by LEE et al [19].…”

Section: Discussionmentioning

confidence: 91%

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Lung cancer in patients with idiopathic pulmonary fibrosis

Park¹,

Kim²,

Shim³

et al. 2001

Eur Respir J

247

170

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Idiopathic pulmonary fibrosis (IPF) was reported to be associated with increased risk of lung cancer as a result of the occurrence of atypical or dysplastic epithelial changes in fibrosis which progressed to invasive malignancy. In that situation, the cancer will develop in the area of major fibrosis. To investigate the direct relationship between fibrosis and cancer development, the real concordance rate of the two lesions in the chest computed tomography (CT) was analysed and compared to the histological types of lung cancer.The subjects included 63 patients with combined lung cancer and IPF (IPF-CA), 218 patients with lone IPF, and 2,660 patients with primary lung cancer. All patients were diagnosed at Asan Medical Center during the same period.The age, percentage of smokers, and the male sex were significantly higher in IPF-CA compared with lone IPF. The odds ratio of smoking was 2.71 compared to nonsmoking IPF controls. In IPF-CA, 56% of the cancer was located in the periphery of the lung and 52% in the upper lobe. The majority of the cancers (64%) were found in the nonfibrotic area at chest CT. The most frequent cell type was squamous cell carcinoma (35%), and there was no significant difference in the cancer cell type between IPF-CA and total lung cancer population.These findings suggest that in combined lung cancer and idiopathic pulmonary fibrosis patients, the features of the lung cancer are similar to the total lung cancer population.

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Section: Discussionmentioning

confidence: 91%

“…The peripheral location of the lung cancer was reported as 88% by NAGAI and CHIYOTANI [5], 91% by MIZUSHIMA and KOBAYASHI [2] and 66% by LEE et al [19]. If fibrosis is directly related to the development of the cancer, cancer will develop inside or in close proximity to the area of major fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Lung cancer in patients with idiopathic pulmonary fibrosis

Park¹,

Kim²,

Shim³

et al. 2001

Eur Respir J

247

170

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“…The prevalence of lung cancer among IPF patients was reported in 15 studies [26,28,34,48,[82][83][84][85][86][87][88][89][90][91][92] (online supplementary table S4 and figure 5) and was typically lower than the prevalence of other respiratory comorbidities of interest. Analyses of insurance claims and electronic medical records databases from the USA and the UK estimated the prevalence of lung cancer to be 3-4% [26,82,83].…”

Section: Lung Cancermentioning

confidence: 95%

Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review

et al. 2015

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Idiopathic pulmonary fibrosis (IPF) is associated with a fatal prognosis and manifests in patients over 60 years old who may have comorbidities. The prevalence and impact of comorbidities on the clinical course of IPF is unclear.This systematic literature review examined the prevalence of comorbidities and mortality associated with comorbidities in IPF patients. Relevant observational studies published in English from January 1990 to January 2015 identified via MEDLINE and EMBASE were included; bibliographies of articles were also searched.Among the 126 studies included, prevalence of pulmonary hypertension (PH) was 3-86%, 6-91% for obstructive sleep apnoea, 3-48% for lung cancer and 6-67% for chronic obstructive pulmonary disease (COPD). Nonrespiratory comorbidities included ischaemic heart disease (IHD) (3-68%) and gastrooesophageal reflux (GER) (0-94%). Mortality was highest among patients with IPF and lung cancer. Most studies assessed relatively small samples of patients with IPF.PH, COPD, lung cancer, GER and IHD are significant comorbidities; differences in IPF severity, case definitions and patient characteristics limited the comparability of findings. The identification and prompt treatment of comorbidities may have a clinically significant impact on overall outcome that is meaningful for patients with IPF. @ERSpublications Identification and prompt treatment of comorbidities has a clinically significant impact on outcome for IPF patients

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“…In fact, it is mainly in systemic sclerosis (62) and cryptogenic fibrosing alveolitis (63,64) that any larger number of lung cancers are found. The risk of lung cancer in silicosis is also moderately increased (relative ratio 3.4 for smokers with silicosis and 1.7 for nonsmokers) (65)(66)(67).…”

Section: Increased Risk Of Lung Cancer In Other Types Of Lung Fibrosimentioning

confidence: 99%

“…The typical cancers in systemic sclerosis are peripheral adenocarcinomas or bronchioalveolar cell carcinomas (62), but those in idiopathic fibrosis are similar to the bronchial carcinomas found in smokers (63,64,68). Of special interest is the review by Mizushima & Kobayashi (68).…”

Section: Increased Risk Of Lung Cancer In Other Types Of Lung Fibrosimentioning

confidence: 99%

Asbestos, asbestosis, pleural plaques and lung cancer

Hillerdal¹,

Henderson²

1997

Scand J Work Environ Health

122

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Hillerdal G, Henderson DW. Asbestos, asbestosis, pleural plaques and lung cancer. Scand J Work Environ Health 1997;23(2):93-103.Inhalation of asbestos fibers increases the risk of bronchial carcinoma. It has been claimed that asbestosis is a necessary prerequisite for the malignancy, but epidemiologic studies usually do not have enough statistical strength to prove that asbestos-exposed patients without asbestosis are without risk. Several recent studies do actually indicate that there is a risk for such patients. In addition, case-referent studies of patients with lung cancer show an attributable risk for asbestos of 6% to 23%, which is much higher than the actual occurrence of asbestosis among these patients. Thus there is an increasing body of evidence that, at low exposure levels, asbestos produces a slight increase in the relative risk of lung cancer even in the absence of asbestosis. Consequently, all exposure to asbestos must be minimized.

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Lung Cancer in Patients with Idiopathic Pulmonary Fibrosis.

Cited by 100 publications

References 12 publications

Lung cancer in patients with idiopathic pulmonary fibrosis

Lung cancer in patients with idiopathic pulmonary fibrosis

Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review

Asbestos, asbestosis, pleural plaques and lung cancer

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