Lung Cancer in Women

Thomas, Leno; Doyle, L. Austin; Edelman, Martin J.

doi:10.1378/chest.128.1.370

Cited by 149 publications

(44 citation statements)

References 71 publications

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“…According to World Health Organization data and other large studies worldwide, SCC is the most frequent lung cancer in both sexes usually developing in proximal branches of the bronchial trunk [1,11,12]. In our study SCC is also the commonest cancer in both sexes through all studied years.…”

Section: Discussionsupporting

confidence: 69%

“…Hormone replacement therapy and higher estrogen level in blood serum increased risk to develop lung cancer if associated with tobacco smoke. Early menopause was associated with decreased risk particularly of adenocarcinoma [11]. Healthy dietary regime, particularly consumption of fresh fruits and vegetables, reduces risk for lung cancer, especially in nonsmoking women [11,19,24].…”

Section: Discussionmentioning

confidence: 98%

“…In our study SCC is also the commonest cancer in both sexes through all studied years. Smoking is the major risk factor for SCC, as well as air noxae and poor working conditions [11][12][13][14][15][16]. In Serbia smoking in women is threefold higher compared with the world average.…”

Section: Discussionmentioning

confidence: 99%

“…Viral infections, especially human papilloma virus (HPV), may be a possible risk factor for lung cancer. This virus is known to cause cancer of uterine cervix, but according to one study it may also be the cause of pulmonary cancer in nonsmoking women, in whom this virus was recovered from tracheobronchial trunk [11].…”

Section: Discussionmentioning

confidence: 99%

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Lung cancer in women: histological type and patient age from 1985 to 2005

et al. 2008

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Lung cancer in women: histological type and patient age from 1985 to 2005

et al. 2008

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“…The gender-specific effects may be due to a variety of mechanisms, ranging from different behavior between genders such as smoking habits, gender-specific lifestyle, sex hormones, as well as genetic and epigenetic differences (69). In our study, women with variant allele(s) were associated with increased lung cancer risk while asbestos exposure were associated with null associations among homozygous wildtype women carriers (Table 5).…”

Section: Discussionmentioning

confidence: 99%

Genome-wide Gene–Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk

Liu¹,

Stücker

Chen³

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Occupational asbestos exposure has been found to increase lung cancer risk in epidemiological studies. Methods We conducted an asbestos exposure-gene interaction analyses among several Caucasian populations who were current or ex-smokers. The discovery phase included 833 Caucasian cases and 739 Caucasian controls, and used a genome-wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) with gene-asbestos interaction effects. The top ranked SNPs from the discovery phase were replicated within the International Lung and Cancer Consortium (ILCCO). First, in silico replication was conducted in those groups that had GWAS and asbestos exposure data, including 1,548 cases and 1,527 controls. This step was followed by de novo genotyping to replicate the results from the in silico replication, and included 1,539 cases and 1,761 controls. Multiple logistic regression was used to assess the SNP-asbestos exposure interaction effects on lung cancer risk. Results We observed significantly increased lung cancer risk among MIRLET7BHG (MIRLET7B host gene located at 22q13.31) polymorphisms rs13053856, rs11090910, rs11703832, and rs12170325 heterozygous and homozygous variant allele(s) carriers [p<5×10−7 by likelihood ratio test; df=1]. Among the heterozygous and homozygous variant allele(s) carriers of polymorphisms rs13053856, rs11090910, rs11703832, and rs12170325, each unit increase in the natural log-transformed asbestos exposure score was associated with age-, sex-, smoking status- and center-adjusted ORs of 1.34 (95%CI=1.18–1.51), 1.24 (95%CI=1.14–1.35), 1.28 (95%CI=1.17–1.40), and 1.26 (95%CI=1.15–1.38), respectively for lung cancer risk. Conclusion Our findings suggest that MIRLET7BHG polymorphisms may be important predictive markers for asbestos exposure-related lung cancer. Impact To our knowledge, our study is the first report using a systematic genome-wide analysis in combination with detailed asbestos exposure data and replication to evaluate asbestos-associated lung cancer risk.

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Age- and Sex-Specific Genomic Profiles in Non–Small Cell Lung Cancer

Mostertz¹

2010

JAMA

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Lung Cancer in Women

Cited by 149 publications

References 71 publications

Lung cancer in women: histological type and patient age from 1985 to 2005

Lung cancer in women: histological type and patient age from 1985 to 2005

Genome-wide Gene–Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk

Age- and Sex-Specific Genomic Profiles in Non–Small Cell Lung Cancer

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