Lung cancer in young patients

Capewell, Simon; Wathen, C G; Sankaran, R.; Sudlow, M. F.

doi:10.1016/s0954-6111(96)80010-2

Cited by 37 publications

(41 citation statements)

References 18 publications

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“…There are 4 publications in which lung cancer in young patients was defined as <45 years of age, as in our paper. 13,[28][29][30] Only 2 papers reported identical survival results between young and elderly patients. There were no previous comparisons between subgroups aged <45 and 45-60 years.…”

Section: Discussionmentioning

confidence: 99%

Multicenter analysis of lung cancer patients younger than 45 years in Shanghai

Zhang

Chen

Zhen

et al. 2010

Cancer

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BACKGROUND:The treatment, prognosis, and outcomes of young lung cancer patients have not been fully explored. In addition, there is a pressing need to characterize this subgroup of patients, because there is a trend of increasing incidence in younger patients from Europe and Japan. METHODS: Consecutive, nonselected young patients (<45 years old) with pathologically diagnosed lung cancer treated at 175 qualified hospitals in the greater Shanghai area were included in this analysis. Incidence, prognostic factors, and treatment outcome of lung cancer patients from 2002 to 2006 were documented. A comparison with lung cancer patients of any age was also made. RESULTS: A total of 12,380 patients with nonsmall cell lung cancer were registered. Among them, 652 patients were between 15 and 45 years old. One-year, 3-year, and 5-year survival rates of lung cancer patients younger than 45 years were 49.87%, 26.68%, and 23.12%, respectively. TNM stage, treatment hospital (tertiary vs community hospital), sex, and cancer histology were confirmed as independent prognostic factors. Compared with lung cancer patients of any age in Shanghai, the percentage of adenocarcinoma in the young male subgroup was significantly higher (63.77% vs 43.19%, P < .001). Interestingly, median survival time of young lung cancer patients was similar with that of lung cancer patients of any age, but was significantly shorter than the median survival of middle-aged patients (45-60 years old). CONCLUSIONS: Median survival of the middle-aged group (45-60 years) was significantly longer than the young group (<45 years) and the old group (>60 years). Therefore, aggressive treatment modalities should be strongly considered for young lung cancer patients. Cancer 2010;116;3656-62.

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Section: Discussionmentioning

confidence: 99%

Multicenter analysis of lung cancer patients younger than 45 years in Shanghai

Zhang

Chen

Zhen

et al. 2010

Cancer

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“…This view has been supported by several studies that revealed lower survival rates in younger patients. 3,8,9,13,14) However, other studies have demonstrated similar or better survival rates in younger patients than those of older patients. 3-5, 10, 11, 15, 16) Table V, which includes only data from studies involving satisfactory numbers of subjects and/or that were statistically managed, shows that results of these studies have been biased by differences in the databases used and that some studies only evaluated patients who underwent surgical resection.…”

Section: Discussionmentioning

confidence: 99%

“…Some investigators have found that adenocarcinoma is the most frequent histologic subtype in younger lung cancer patients, 2,3,[5][6][7][8][9][10] whereas others have reported that squamous cell carcinoma is the most frequent subtype. 3,11,12) In addition, several reports have suggested a poor prognosis in younger patients with lung cancer, 3,8,9,13,14) whereas others have suggested that there is no significant difference in long-term survival between younger and older patients. 3-5, 10, 11, 15, 16) Possible causes for these conflicting results may include differences in the definition of younger patients, the stage of disease at presentation, treatments the patients received, and genetic and environmental differences (including the age at which smoking commenced) 2) in the populations studied.…”

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confidence: 99%

Lung Cancer in Patients under 50 Years Old

Tominaga¹,

Mori²,

Yokoi³

et al. 1999

Japanese Journal of Cancer Research

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A long-term retrospective study was carried out on 790 cases of lung cancer to determine if the clinicopathologic characteristics and survival rates of lung cancer patients under the age of 50 differ from those of patients 50 years of age or older at diagnosis by analyzing data on patients registered at Tochigi Cancer Center Hospital. Of the 790 patients, 77 (9.7%) were under the age of 50 at diagnosis. The percentage of women in the younger patient group was significantly higher than that in the older patient group (39.0% vs. 27.5%; P = = = =0.034). Tumor histology revealed a significant preponderance of adenocarcinomas (60 patients, 77.9%) and a paucity of squamous cell carcinomas (8 patients, 10.4%) in the younger age group (P< < < <0.001). The preponderance of adenocarcinoma was significant in both males and females (male: P = = = =0.004, female: P = = = =0.004). Smoking rates and rate of detection by cancer screening did not differ between the two age groups. Because of the paucity of smokers among the younger female patients, causes of lung cancer other than smoking should be sought in younger patients. No difference was found in the stage of the disease at presentation, treatment methods and survival rates between the two age groups. It is suggested that the prognosis for patients with lung cancer under the age of 50 is not significantly worse than for those aged 50 years or older, as has been shown by several investigators.

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“…Lung cancer in young adults has several unique characteristics: a high percentage of patients are female, more adenocarcinoma, and more advanced stage at the time of diagnosis, and more patients receiving aggressive treatment [8][9][10][11]. Previous studies have shown that young patients had a similar survival as older patients [12].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Adenocarcinoma in the Young Adult

Mehta¹,

Jain²,

Desai³

et al. 2017

Arch Surg Oncol

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We report a case of metastatic adenocarcinoma pleura in a non-smoking 29-year-old man. X-ray Chest revealed Left sided repeated pleural effusion despite repeated tapping. CT revealed a moderate Left sided pleural effusion. A VATS biopsy of the Left Pleural Nodules and Left lung nodules revealed a metastatic adenocarcinoma. He was a non-smoker and molecular markers revealed an EGFR Mutation and were started on oral TKI. He had near complete resolution after 6 months except for mild thickening of the pleura at the base.

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Lung cancer in young patients

Cited by 37 publications

References 18 publications

Multicenter analysis of lung cancer patients younger than 45 years in Shanghai

Multicenter analysis of lung cancer patients younger than 45 years in Shanghai

Lung Cancer in Patients under 50 Years Old

Metastatic Adenocarcinoma in the Young Adult

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