Lung Cancer: Mechanisms of Carcinogenesis

Anttila, Sisko; Nymark, Penny

doi:10.1007/978-1-4471-2825-0_10

Cited by 2 publications

(3 citation statements)

References 230 publications

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“…Stringent environmental regulations are in place in several countries for limiting PCDD/PCDF emissions. [6,7] Central Pollution Control Board (CPCB) of India has regulated the amount of total dioxins and furans released from any incinerator as 0.1 ng (TEQ)/Nm 3 .…”

Section: Introductionmentioning

confidence: 99%

“…[1][2] These POPs have been correlated to the different behavioural, reproductive, developmental, endocrine, neurologic, and immunologic adverse health effects in human beings. [3] In animals, they have caused diseases and abnormalities in a number of wildlife species including certain kinds of birds, fish, and mammals. [3] One of the most discussed POPs are the Polychlorinated Dibenzo-para-dioxin (PCDDs) and Polychlorinated dibenzofuran (PCDFs) which have 210 congeners are collectively known as Dioxin and Furan (D&F).…”

Section: Introductionmentioning

confidence: 99%

“…[3] In animals, they have caused diseases and abnormalities in a number of wildlife species including certain kinds of birds, fish, and mammals. [3] One of the most discussed POPs are the Polychlorinated Dibenzo-para-dioxin (PCDDs) and Polychlorinated dibenzofuran (PCDFs) which have 210 congeners are collectively known as Dioxin and Furan (D&F). Out of this 17 congeners are highly toxic and are considered as A1 carcinogens with 2,3,7,8-Tetrachloro p-dibenzo Dioxin (2,3,7,8-TCDD) having Toxicity Equivalent Factor (TEF) = 1 (LD 50 = 0.04 mg/kg) identified as the most toxic compound.…”

Section: Introductionmentioning

confidence: 99%

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Role of Constituent Oxides for Thermal Mineralization of o‐Dichloro Benzene over Mixed‐Oxide‐TiO₂ Catalysts: A Mechanistic Explanation

Bhattacharyya,

Kumar,

Tyagi

et al. 2024

ChemPhysChem

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Catalysts with V2O5, WO3 and V2O5‐WO3 dispersed over TiO2 were synthesized using sol‐gel technique and thoroughly characterized by various techniques. The catalysts were evaluated for degradation of ortho‐dichloro benzene (o‐DCB) in air/helium, a representative probe molecule for polychlorinated dibenzo‐para‐dioxin and polychlorinated dibenzofuran by employing in situ Fourier‐transform infrared spectroscopy (FT‐IR spectroscopy). Different intermediate species formed on the surface of the TiO2 supported catalysts through of interaction of sorbate molecules with the lattice and/or gaseous oxygen were investigated in detail. Analysis of vibrational bands, observed during sorption of o‐DCB and o‐DCB‐air mixture as a function of temperature over these catalysts, delineated the role of surface intermediate species such as phenolate, enolates, maleates, carboxylates, carbonates in mineralization of o‐DCB. Nature and stability of intermediate species, found to be different over these catalysts, were able to elucidate the catalytic activity trend

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of Constituent Oxides for Thermal Mineralization of o‐Dichloro Benzene over Mixed‐Oxide‐TiO₂ Catalysts: A Mechanistic Explanation

Bhattacharyya,

Kumar,

Tyagi

et al. 2024

ChemPhysChem

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Toxic and Genomic Influences of Inhaled Nanomaterials as a Basis for Predicting Adverse Outcome

Nymark

Kohonen

Hongisto³

et al. 2018

Annals ATS

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An immense variety of different types of engineered nanomaterials are currently being developed and increasingly applied to consumer products. Importantly, engineered nanomaterials may pose unexplored adverse health effects because of their small size. Particularly in occupational settings, the dustiness of certain engineered nanomaterials involves risk of inhalation and influences on lung function. These facts call for quick and cost-effective safety testing practices, such as that obtained through multiparametric high-throughput screening using cultured human lung cells. The predictive value of such in vitro-based testing depends partly on the effectiveness of coverage of the mechanisms underlying toxicity effects. The concept of adverse outcome pathways covers the array of causative effects starting from a molecular initiating event via cellular-, organ-, individual-, and population-level effects. Screening for adverse outcome pathway-related effects that drive the eventual toxic outcome provides a good basis for developing predictive testing methods and data-driven integrated testing strategies for hazard and risk assessment. Temporal and inherited genomic changes are likely to drive many adverse responses to engineered nanomaterials, such as multiwalled carbon nanotubes, of which one specific form has recently been evaluated as possibly carcinogenic. Here, we briefly describe current state-of-the-art strategies for analyzing and understanding genomic influences of engineered nanomaterial exposure, including the selected focus on lung disease, and strategies for using mechanistic knowledge to predict and prevent adverse outcome.

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Lung Cancer: Mechanisms of Carcinogenesis

Cited by 2 publications

References 230 publications

Role of Constituent Oxides for Thermal Mineralization of o‐Dichloro Benzene over Mixed‐Oxide‐TiO₂ Catalysts: A Mechanistic Explanation

Role of Constituent Oxides for Thermal Mineralization of o‐Dichloro Benzene over Mixed‐Oxide‐TiO₂ Catalysts: A Mechanistic Explanation

Toxic and Genomic Influences of Inhaled Nanomaterials as a Basis for Predicting Adverse Outcome

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Lung Cancer: Mechanisms of Carcinogenesis

Cited by 2 publications

References 230 publications

Role of Constituent Oxides for Thermal Mineralization of o‐Dichloro Benzene over Mixed‐Oxide‐TiO2 Catalysts: A Mechanistic Explanation

Role of Constituent Oxides for Thermal Mineralization of o‐Dichloro Benzene over Mixed‐Oxide‐TiO2 Catalysts: A Mechanistic Explanation

Toxic and Genomic Influences of Inhaled Nanomaterials as a Basis for Predicting Adverse Outcome

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Product

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Role of Constituent Oxides for Thermal Mineralization of o‐Dichloro Benzene over Mixed‐Oxide‐TiO₂ Catalysts: A Mechanistic Explanation

Role of Constituent Oxides for Thermal Mineralization of o‐Dichloro Benzene over Mixed‐Oxide‐TiO₂ Catalysts: A Mechanistic Explanation