Lung Cancer Receptors and Targeting Strategies

Koli, Uday; Dey, Anomitra; Nagendra, Prathima B.; Devarajan, Padma V.; Jain, Ratnesh; Dandekar, Prajakta

doi:10.1007/978-3-030-29168-6_8

Cited by 3 publications

(1 citation statement)

References 131 publications

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“…Targeting the receptors, overexpressed in cancers, has opened new opportunities for intracellular targeting of drugs and delivery systems that are conjugated with targeting moieties, that is the ligands. This receptor-mediated targeting of anticancer drugs, especially using nanosized carrier systems, protected them from the degrading body environment and improves their pharmacokinetic properties by extending their circulation time within the body as shown in Fig 12. Moreover, it also helps to overcome the systemic toxicity and adverse effects that arise due to the nonselective nature of most of the current anticancer therapeutic agents [67]. Additionally, the particle's surface charge can also affect cellular uptake, with positively charged particles being more readily endocytosed.…”

Section: Figure 11 Schematic Representation Of the Endocytic Pathways...mentioning

confidence: 99%

Design and synthesis of modified chitosan/collagen coated-gold nanoparticles as a carrier for anticancer and antiinflammatory agents

Hongsa¹

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The proposes of this research are to improve the delivery efficiency of AuNPs. One of the problems with drug loading and drug degradation, the drug was loaded onto the surface of the gold particles, adheres to the outer of the surface, which was easy to decompose in the body. In this work, we have developed the coated AuNPs by modified chitosan (Bi-QCS), which the Biotin-Quat188-AuNPs@collagen (Bi-QCS-AuNPS@collagen) was designed as follow: (i) collagen was used as a reducing agent and a stabilizing agent in the AuNPs@collagen, while (ii) modified chitosan (positive charge polymer) was coated on the outer layer, which modified chitosan (Bi-QCS) was consists of a positive charge (Quat188) and a targeting molecule (biotin) to increase cellular uptake and control drug release. After that, 5-Fluorouracil (5-FU) as an anticancer agent was loaded into BiQCS-AuNPs@collagen. The Bi-QCS-AuNPs@collagen was characterized by many techniques. The particle size of AuNPs@collagen increased after coating with Bi-QCS from 30 nm to 50 nm, while the zeta potential change from a negative value (uncoated) to a positive value (coated with Bi-QCS). The coating of Bi-QCS on the surface of AuNPs@collagen can increase the loading efficiency was 87.46 %, while the AuNP@collagen shows a loading efficiency of only 64.67 %. In addition, Bi-QCS-AuNPs@collagen can control the drug release rate, which at pH 5.4 showed the drug release rate higher than pH 7.4 after 48 hours. The evaluation of the biological activity of Bi-QCS-AuNPs@collagen presented significantly higher anti-inflammatory activity and anticancer activity of 5-FU.

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Section: Figure 11 Schematic Representation Of the Endocytic Pathways...mentioning

confidence: 99%

Design and synthesis of modified chitosan/collagen coated-gold nanoparticles as a carrier for anticancer and antiinflammatory agents

Hongsa¹

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Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers

Rawal

Patel

2021

Nano-Micro Lett.

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Lung cancer is a complex thoracic malignancy developing consequential to aberrations in a myriad of molecular and biomolecular signaling pathways. It is one of the most lethal forms of cancers accounting to almost 1.8 million new annual incidences, bearing overall mortality to incidence ratio of 0.87. The dismal prognostic scenario at advanced stages of the disease and metastatic/resistant tumor cell populations stresses the requisite of advanced translational interdisciplinary interventions such as bionanotechnology. This review article deliberates insights and apprehensions on the recent prologue of nanobioengineering and bionanotechnology as an approach for the clinical management of lung cancer. The role of nanobioengineered (bio-nano) tools like bio-nanocarriers and nanobiodevices in secondary prophylaxis, diagnosis, therapeutics, and theranostics for lung cancer management has been discussed. Bioengineered, bioinspired, and biomimetic bio-nanotools of considerate translational value have been reviewed. Perspectives on existent oncostrategies, their critical comparison with bio-nanocarriers, and issues hampering their clinical bench side to bed transformation have also been summarized.

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A Systematic Mapping Study of detection of Tumor Cell Targeted by Enzymes though Cerebrospinal Fluid

Saeed¹,

Abbasi²,

Hashim³

2023

Clin Cancer Investig J

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Cancers, especially of the neural tissue, are often deemed a death sentence. There is, however, still no clear understanding of the underlying causes nor the cellular and molecular mechanisms of this disease. The spread and collateral damage caused by various types of brain tumors remain poorly understood, despite the information that is currently available about these diseases. A common means of diagnosing tumors is through cerebrospinal fluid (CSF) leakage, and the enzymes from brain cancer cases were investigated within this hypothesis. The purpose of this study was to investigate the role of CSF in brain cancer and BBB. This study conducted a systematic study of leakage that typically occurs at the spine level, namely in the thoracic spine region and the base of the brain along the cardiothoracic connection. This study investigated the bacteria sampling of brain cancer in CSF and determined the common method of targeting cancer cells in the brain and enzymes contained within the CSF. A further finding reveals the precise foci of this leakage and various proteins and enzymes that may be responsible for this damage, as well as evidence that the release of tumor components damages the CSF. As a result of these observations, enzymes and tumor cells are detected, and a new component identifies tumor-related CSF.

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Lung Cancer Receptors and Targeting Strategies

Cited by 3 publications

References 131 publications

Design and synthesis of modified chitosan/collagen coated-gold nanoparticles as a carrier for anticancer and antiinflammatory agents

Design and synthesis of modified chitosan/collagen coated-gold nanoparticles as a carrier for anticancer and antiinflammatory agents

Bio-Nanocarriers for Lung Cancer Management: Befriending the Barriers

A Systematic Mapping Study of detection of Tumor Cell Targeted by Enzymes though Cerebrospinal Fluid

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