Lung Cancer Risk in White and Black Americans

Stellman, Steven D.; Chen, Yu; Muscat, Joshua E.; Djordjevic, Mirjana V.; Richie, John P.; Lazarus, Philip; Thompson, Seth; Altorki, Nasser K.; Berwick, Marianne; Citron, Marc L.; Harlap, Susan; Kaur, Tajinder; Neugut, Alfred I.; Olson, Sara H.; Travaline, John M.; Witorsch, Philip; Zhang, Zuo‐Feng

doi:10.1016/s1047-2797(02)00420-9

Cited by 92 publications

(94 citation statements)

References 36 publications

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“…According to our estimates for Icelandic LC patients, the correlation between SQ and LC is consistent with numbers reported in other studies 26,27 . Combining these estimates with our estimate of the association of the variant with SQ, the expected OR between the variant and LC is only about 1.05 in Iceland (See Supplementary Information), which is well below the direct OR estimate for LC of 1.27 (95%CI: 1.13-1.43).…”

supporting

confidence: 93%

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Thorgeirsson¹,

Geller²,

Sulem³

et al. 2008

Nature

1,402

1,247

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Smoking is a leading cause of preventable death, causing approximately five million premature deaths world-wide each year 1, 2 . Evidence for genetic influence on smoking behaviour and nicotine dependence (ND) 3-8 has prompted a search for susceptibility genes. Furthermore, assessing the impact of sequence variants on smoking-related diseases is important for public health reasons 9, 10 . Smoking is the major risk factor for lung cancer (LC) [11][12][13][14] , and one of the main risk factors for peripheral arterial disease (PAD) [15][16][17] . We have identified a common variant in the nicotinic acetylcholine receptor gene cluster on chromosome 15q24 with an effect on smoking quantity, ND and the risk of two smoking-related diseases in populations of European descent. The variant has an effect on the number of cigarettes smoked per day in 15,771 smokers (P=6×10 −20 ). The same variant associated with ND in a previous genome-wide association study using low quantity smokers as controls (OR=1.3, P=1×10 −3 ) 18,19 , and with a similar approach we observe a highly significant association with ND (OR =1.40, P=7×10 −15 ). Comparison of LC (N=1,024) and PAD (N= 2,738) cases with about 30,000 population controls each showed that the variant confers risk of LC (OR=1.31, P=1.5×10 −8 ) and PAD (OR=1.19, P=1.4×10 −7 ). The findings highlight the role of nicotine addiction in the pathogenesis of other serious diseases and provide a case study of the role of active gene-environment correlation 20 in the pathogenesis of disease.To perform a genome-wide association (GWA) study of smoking quantity (SQ), we utilised questionnaire data limited to basic questions on smoking behaviour that were available for a large number of lifetime smokers. The GWA scan comprises 10,995 Icelandic smokers who Reprints and permissions information is available at www.nature.com/reprints.

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supporting

confidence: 93%

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Thorgeirsson¹,

Geller²,

Sulem³

et al. 2008

Nature

1,402

1,247

View full text Add to dashboard Cite

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“…Studies of the effects of smoking menthol cigarettes are now emerging. In 1989, the first epidemiological study of health effects of smoking menthol cigarettes was published (Hebert & Kabat, 1989), and several others have followed (Carpenter, Jarvik, Morgenstern, McCarthy, & London, 1999;Kabat & Hebert, 1991, 1994Sidney, Tekawa, Friedman, Sadler, & Tashkin, 1995;Stellman et al, 2003). To date, epidemiological studies of the relationship between smoking menthol cigarettes and cancer risk have shown mixed results and have been limited by problems such as too few subjects exclusively smoking menthol cigarettes for too short a time.…”

Section: Emerging Research On Menthol Cigarettesmentioning

confidence: 99%

Menthol Cigarettes: Setting the Research Agenda

Clark

Gardiner

Djordjevic

et al. 2004

CNTR

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“…However, regular smokers are highly heterogeneous (Furberg et al, 2005) and level of cigarette use may be an important consideration. For instance, smoking pattern typically differs by racial group (Stellman et al, 2003; USDHHS, 1989;White et al, 2004). And smoking even one cigarette per day may be harmful to individuals with compromised immune functioning.…”

mentioning

confidence: 99%

Cigarette Smoking among HIV+ Men and Women: Examining Health, Substance Use, and Psychosocial Correlates across the Smoking Spectrum

et al. 2007

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The prevalence of cigarette smoking among HIV+ individuals is greater than that found in the general population. However, factors related to smoking within this population are not well understood. This study examined the associations between smoking and demographic, medical, substance use, and psychosocial factors in a clinic-based sample of HIV+ men and women. Two hundred twelve participants completed self-report measures of tobacco use, HIV-related symptoms, viral load, CD4, alcohol and illicit drug use, depression, and social support. Multinomial logistic regression analyses modeled the independent associations of the cross-sectional set of predictors with smoking status. Results indicated that 74% of the sample smoked at least one cigarette per day; using standard definitions, 23% of the sample were light smokers, 22% were moderate smokers, and 29% smoked heavily. Smoking was associated with more HIV-related symptoms, greater alcohol and marijuana use, and less social support. Light smoking was related to minority race/ethnicity and less income; moderate smoking was associated with less education; and heavy smoking was related to less education and younger age. Viral load, CD4 count, and depression were not associated with smoking status. Psychosocial interventions targeting this population should consider the relationships between biopsychosocial factors and smoking behavior. High Smoking Prevalence among HIV+ Men and Women: Examining Health, Substance Use, and Psychosocial Correlates across the Smoking SpectrumSmoking is highly prevalent among persons living with HIV and may contribute to premature morbidity and mortality. Among HIV+ individuals, prevalence rates of smoking range from 50% to 70% (Burkhalter et al., 2005;Miguez-Burbano et al., 2005;Niaura et al., 2000) compared to 21% for the general population (CDC, 2005). Smoking is strongly associated with two of the primary causes of illness and death in HIV+ patients: community-acquired pneumonia (CAP) and Pneumocystis jiroveci pneumonia (formerly known as Pneumocystis ciroveci; Arcavi & Benowitz, 2004;Miguez-Burbano et al., 2005). HIV+ smokers are also at increased risk for oral lesions (Palacio et al., 1997) Beck & Slade, 1996), and AIDS-related spontaneous pneumothorax (Metersky et al., 1995).Young smokers infected with HIV may be particularly vulnerable to malignant tumors, such as lung cancer (Patel et al., 2006;Spano et al., 2004). Moreover, smoking by HIV+ patients may facilitate the progression to Acquired Immune Deficiency Syndrome (AIDS) (Neiman et al., 1993).Evidence also suggests that smoking has adverse effects on the health-related quality of life (HRQL) of HIV+ men and women. Vidrine et al. (2006) tested a framework for HRQL of life among HIV+ individuals. They found that HRQL is influenced by relationships among physical symptoms, and cognitive, psychological, and social functioning (Brenner et al., 1995;Wilson & Cleary, 1995). They also found that smoking, alcohol use, and SES impair overall HRQL. Other work has also found rel...

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Lung Cancer Risk in White and Black Americans

Cited by 92 publications

References 36 publications

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

Menthol Cigarettes: Setting the Research Agenda

Cigarette Smoking among HIV+ Men and Women: Examining Health, Substance Use, and Psychosocial Correlates across the Smoking Spectrum

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