Lung cancer survival among never smokers

Casal-Mouriño, Ana; Valdés, Luis; Barros-Dios, Juan Miguel; Ruano-Raviña, Alberto

doi:10.1016/j.canlet.2019.02.047

Cited by 46 publications

(31 citation statements)

References 30 publications

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“…Lung cancer is the most common cancer (11.6 % of total cancers) and the leading cause of death from cancers worldwide (18.4 % of total cancer deaths) [1], with adenocarcinoma being the most common histological type of lung cancer [2,3]. A new classification of lung adenocarcinoma was established in 2011, dividing lung adenocarcinoma into atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) [4], consistent with the classification of lung adenocarcinoma published by WHO in 2015 [5].…”

Section: Introductionmentioning

confidence: 99%

Joint use of the radiomics method and frozen sections should be considered in the prediction of the final classification of peripheral lung adenocarcinoma manifesting as ground-glass nodules

Wang

Tang

Chen³

et al. 2020

Lung Cancer

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Section: Introductionmentioning

confidence: 99%

Joint use of the radiomics method and frozen sections should be considered in the prediction of the final classification of peripheral lung adenocarcinoma manifesting as ground-glass nodules

Wang

Tang

Chen³

et al. 2020

Lung Cancer

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“…The literature confirms that lung cancer among non-smokers exhibits distinctive clinical characteristics, is more common in women and is diagnosed at later stages and that adenocarcinoma is the predominant histological type [ 31 , 32 , 33 ]. Meanwhile, tobacco smoking is associated with squamous and small cell types of lung cancer, as well as with an earlier age at the time of diagnosis [ 34 ], which leads to a generally poorer prognosis for patients in this group.…”

Section: Discussionmentioning

confidence: 78%

Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status

et al. 2021

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The aim of the study was to compare the metabolic characteristics of the salivary composition in lung cancer, chronic obstructive pulmonary disease (COPD) and their combination, depending on the smoking history. The study group included 392 patients with lung cancer of various histological types. The division into subgroups was carried out in accordance with the severity of COPD and smoking experience. Salivary biochemical composition was determined according to 34 indicators. For data processing, the principal component method was used. Different groups of biochemical saliva markers are informative when separately accounting for the smoking factor and the presence of COPD in lung cancer. For smoking, antioxidant enzymes and electrolyte components of saliva are informative; for COPD metabolic enzymes, lipid peroxidation products, sialic acids and electrolyte components are informative. While taking into account the smoking factor and the presence of COPD, biochemical markers corresponding to the presence/absence and severity of COPD are the priority. Changes occurring in the background of smoking are of a secondary nature, manifesting as much as possible with a smoking history of more than 50 pack-years. Thus, the metabolic changes that occur in lung cancer in combination with COPD, depending on the smoking factor, can be estimated using saliva.

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“…These techniques are usually not practical, and are expensive, for most early NSCLC detection ( 4 ). According to Hu et al ( 5 ) and Chen et al ( 6 ), serum miRNA, as a potential biomarker for the diagnosis and prediction of prognosis of lung cancer, and may be useful for the detection of NSCLC and provides high sensitivity and specificity ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Expression and clinical significance of microRNA‑21, PTEN and p27 in cancer tissues of patients with non‑small cell lung cancer

Yang

2020

Oncol Lett

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Expression and clinical significance of micro-RNA-21, PTEN and p27 in cancer tissue of patients with non-small cell lung cancer (NSCLC) were investigated. In this study, cancer tissue and adjacent tissue specimens from 230 patients with NSCLC were collected from thoracic surgery department in Hubei Cancer Hospital from March 2010 to February 2016. The expression of miRNA-21, PTEN and p27 in cancer tissue and adjacent tissue of patients with NSCLC was detected by RT-PCR. Combined with clinical information, the correlation among miRNA-21, PTEN, p27 and clinical features of NSCLC was analyzed. The expression of miRNA-21, PTEN, p27 in NSCLC was significantly lower than that in adjacent tissue by RT-PCR (P<0.05). There was no significant difference in age, sex and course of disease (P>0.050), but there were differences in smoking, lymph node metastasis, TNM stage and differentiation degree classification (P<0.050). By comparing the 3-year survival rate in the group with high and low expression of miRNA-21, PTEN and p27, it was found that the 36-month survival rate of patients with high expression of miRNA-21 was 85.19% (P<0.05), and of patients with low expression of miRNA-21 it was 95.90% (P<0.05). The 36-month survival rate of patients with high expression of PTEN was 85.59% (P<0.05), of patients with low expression of PTEN it was 94.96% (P<0.05) and in patients with high expression of p27 it was 84.91% (P<0.05). The 36-month survival rate of patients with low expression of p27 was 94.35% (P<0.05). The survival rates of miRNA-21, PTEN and p27 low expression groups were significantly higher than those of high expression groups (P<0.05). In conclusion, the expression of miRNA-21, PTEN and p271 in cancer tissue of NSCLC patients was low. The three indexes have good diagnostic efficacy based on ROC curve analysis, and are expected to be excellent indexes for early clinical diagnosis and prognosis of NSCLC.

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Lung cancer survival among never smokers

Cited by 46 publications

References 30 publications

Joint use of the radiomics method and frozen sections should be considered in the prediction of the final classification of peripheral lung adenocarcinoma manifesting as ground-glass nodules

Joint use of the radiomics method and frozen sections should be considered in the prediction of the final classification of peripheral lung adenocarcinoma manifesting as ground-glass nodules

Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status

Expression and clinical significance of microRNA‑21, PTEN and p27 in cancer tissues of patients with non‑small cell lung cancer

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Lung cancer survival among never smokers

Cited by 46 publications

References 30 publications

Joint use of the radiomics method and frozen sections should be considered in the prediction of the final classification of peripheral lung adenocarcinoma manifesting as ground-glass nodules

Joint use of the radiomics method and frozen sections should be considered in the prediction of the final classification of peripheral lung adenocarcinoma manifesting as ground-glass nodules

Features of the Metabolic Profile of Saliva in Lung Cancer and COPD: The Effect of Smoking Status

Expression and clinical significance of microRNA‑21, PTEN and p27 in cancer tissues of&nbsp;patients with non‑small cell lung cancer

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Expression and clinical significance of microRNA‑21, PTEN and p27 in cancer tissues of patients with non‑small cell lung cancer