2019
DOI: 10.1002/ppul.24260
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Lung disease and vitamin D levels in cystic fibrosis infants and preschoolers

Abstract: Introduction: Vitamin D acts on the immune system and lung response. Patients with cystic fibrosis (CF) may be deficient in this vitamin. The aims of the study were to evaluate vitamin D levels and severity of lung disease in infants and preschoolers diagnosed with CF, and to compare them to a group of children without pancreatic insufficiency (PI). Methods: Patients with CF up to 4 years old were included, and compared to an agematched group of children without diagnosis of CF. CF group had medical records an… Show more

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Cited by 11 publications
(9 citation statements)
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“…Associations between vitamin D status, lung function, and exacerbations are unclear. Indeed, some studies found positive associations with levels of vitamin D and lung function, as measured by FEV1 [47,[49][50][51][52][53][54] while others found no relationship [55][56][57][58]. When we focus on the relationship between serum 25(OH)D levels and exacerbations in CF, most studies reported that deficient vitamin D levels (25(OH)D < 20 ng/ml) are associated with more exacerbations [47,49,50] and more bacterial colonizations [59].…”
Section: Vitamin D In Cystic Fibrosismentioning
confidence: 99%
“…Associations between vitamin D status, lung function, and exacerbations are unclear. Indeed, some studies found positive associations with levels of vitamin D and lung function, as measured by FEV1 [47,[49][50][51][52][53][54] while others found no relationship [55][56][57][58]. When we focus on the relationship between serum 25(OH)D levels and exacerbations in CF, most studies reported that deficient vitamin D levels (25(OH)D < 20 ng/ml) are associated with more exacerbations [47,49,50] and more bacterial colonizations [59].…”
Section: Vitamin D In Cystic Fibrosismentioning
confidence: 99%
“…Vitamin D status can affect growth and immunity and could influence pulmonary function in CF. One 2019 study in 39 children diagnosed by newborn screening found that Vitamin D levels were not correlated with lung disease, body mass index, age, gender, ethnicity, or F508del mutation 64 . In contrast, vitamin D levels were positively correlated with lung function in a longitudinal study of 6 to 20 year olds, but no difference in lung function was found in those with vitamin D levels of 20–30 compared with greater than 30 65 …”
Section: Cystic Fibrosis Airway Infectionmentioning
confidence: 99%
“…Effects/impact of vitamin D supplementation on 25OHD status in cypCF Table 3 summarises 9 out 21 (42.8%) studies reporting 25OHD concentration following vitamin D supplementation. Of these, 1 (11.1%) [51] described 25OHD concentration at one time point and 8 studies (88.9%) investigated the impact of vitamin D supplementation on 25OHD concentration using either observational methodology (n ¼ 7; 77.8%) [39e41, 45,50,52,54] or randomised control trials (n ¼ 2; 22.2%) [22,23]. Fifty % (n ¼ 4) studies demonstrated a statistically significant improvement in 25OHD concentration following vitamin D supplementation (Fig.…”
Section: Associations Between 25ohd Concentration and Pulmonary Exace...mentioning
confidence: 99%