Lung function and blood gas characteristics in the rhesus monkey

Abstract

SUMMARYDetailed information has been obtained on the normal lung mechanics, lung ventilation and blood gases and pH in unanaesthetized, restrained male and female rhesus monkeys. This information is compared with the limited amount of data previously available on lung function in the rhesus monkey, and with the pulmonary characteristics of the baboon and cynomolgus monkey.Ausfiihrliche Angaben wurden tiber den normalen Lungenmechanismus, Lungenventilation und Blutgase und pH in nicht-anasthesierten, unbeweglich gehaltenen mannlichen und weiblichen Rhesusaffen gemacht. Diese Information wird mit den beschrankten Auskiinften verglichen, die bisher tiber die Lungenfunktion des Rhesusaffen vorlag, sowie mit den pulmonaren Charakteristiken des Pavians und des CynomolgusafI:en. LA FONCTION DES POUMONS ET LES TRAITS CARACTERISTIQUES DU GAZ DE SANG CHEZ LES SINGES RHESUSOn a obtenu de l'information detaillee sur la mecanique normale du poumon, la ventilation du poumon et les gazes du sang et Ie pH dans des singes males et femelles Rhesus tenus immobiles et non-anesthesies. Cette information est comparee avec les donnees tres limitees qu'on avait jusqu'alors sur Ie fonctionnement du poumon du singe Rhesus, et avec les traits caracteristiques pulmonaires du babouin et du singe cynomolgus.

Respiratory System Diseases of Nonhuman Primates

“…In certain research situations, however, including toxicology and infectious disease research, some such tests are carried out under controlled circumstances. Reports available in the literature regarding such work include those by Besch et al, (1996), Binns et al, (1972), and Liu and DeLauter (1977).…”

Comparative Physiology, Growth, and Development

“…A neurobehavioral assessment test battery for the macaque has been described to measure the adverse neurological effects of drugs and is similar to tests used in rodents [259]. Respiratory minute volume 24.9 ± 2.38 mL/min [171] 2039 ± 299/min [245] 1630 ± 465 mL/min [141] 6500-9000 mL/min [62] Average pulmonary resistance 0.28 ± 0.03 cm H 2 O·s/mL [171] 0.019 ± 0.005 cm H 2 O·s/mL [245] 0.021 ± 0.009 cm H 2 O·s/mL [141] 1 Current understanding of the molecular and anatomic differences that underlie the cognitive differences between humans and nonhuman primates has been recently reviewed by Geschwind and Rakic [154]. The differences between primates in particular functional domains undoubtedly have molecular and anatomic bases, but these details have only begun to be understood.…”

Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans

“…The subdivision of V̇E into its two components is necessary for accurate deposition modeling because the inhaled particles have varying patterns of deposition depending upon the combination of V T and f. Thus, values of V T and f are needed to calculate material loss in the respiratory tract of rhesus monkeys. While a number of studies have reported group means for V T , f, and V̇E, only 3 studies have reported values of these variables on individual rhesus monkeys where the sex was specified (Karel & Weston, 1946;Brooks et al, 1957;Binns et al, 1972). One animal was judged to be an outlier in each of the studies reporting individual values for these variables, and none of the data for these animals was used in our analyses (Appendix B).…”

“…Breathing frequency-Values of breathing frequency and body weight for the male and female rhesus monkeys studied by Karel and Weston (1946), Brooks et al (1957), and Binns et al (1972) are shown in Figure 7A and 7B, respectively. For animals weighing up to 4.5 kg, the scatter plots clearly show that there is no relationship between breathing frequency and body weight for either sex.…”

“…Given that a number of other rhesus monkey studies have reported group mean breathing frequency, we elected to use the averages of the Karel and Watson (1946), Brooks et al (1957) and Binns et al (1972) studies together with these other study means to determine an overall mean breathing frequency based upon a larger number of animals (Table 10). The study by Kelly et al (1974) was not included in Table 10 because the minute volume for the female animals in that study was basically the same as the minute volume in the Guyton (1947) and Crosfill and Widdicombe (1961) studies that used animals about 2 kg less in size.…”