Lung Function Assessment as an Early Biomonitor of Mercury-Induced Health Disorders in Artisanal and Small-Scale Gold Mining Areas in Indonesia

Abstract

The evaluation of mercury impact on humans is currently nonspecific because the body characteristics (homeostasis) of each human being varies. Therefore, in the early diagnosis of mercury toxicity, one of the most important monitoring parameters is the respiratory function examination. In this study, respiratory function was examined with a portable spirometer and correlated with the mercury levels in hair from the noses and heads of subjects. Samples were taken from artisanal and small-scale gold mining (ASGM) areas (villages of East Tulabolo and Dunggilata) and control areas (villages of Bongo and Longalo) in Gorontalo Province, Indonesia. A statistical analysis with the Mann–Whitney test (alternative) showed significant differences in lung function between the polluted and control areas (α = 0.03). The analysis of nasal and head hair samples with particle-induced X-ray emissions (PIXE) showed that the mercury levels in the ASGM area were considerably higher than in the more homogeneous control areas. This study confirms that a pulmonary function test is a quick and precise alternative way to monitor the impact of mercury on humans, especially atmospheric mercury, because we detected a negative correlation between pulmonary function and the level of mercury in hair.

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“…Although respiratory dysfunction is known to be the characteristic feature of acute mercury (Hg) vapor inhalation ( Smiechowicz et al, 2017 ), data on the relationship between environmental Hg pollution and pulmonary function are rather insufficient. Previous studies revealed a significant inverse association between hair Hg and respiratory function in subjects from artisanal and small-scale gold mining areas ( Pateda et al, 2018 ). High serum Hg levels (third tertile) were associated with increased odds of obstructive lung disease (OR= 3.62; 95%CI: 1.29-10.18) in a dusty area ( Heo et al, 2017 ).…”

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