Lung Function Changes in Sprague-Dawley Rats After Prolonged Inhalation Exposure to Silver Nanoparticles

Sung, Jae Hyuck; Ji, Jun Ho; Yoon, Jin Uk; Kim, Dae Seong; Song, Moon Yong; Jeong, Jayoung; Han, Beom Seok; Han, Jeong Hee; Chung, Yong Hyun; Kim, Jeongyong; Kim, Tae Sung; Chang, Hee Kyung; Lee, Eun Jung; Lee, Ji Hyun; Yu, Il Je

doi:10.1080/08958370701874671

Cited by 333 publications

(210 citation statements)

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“…In a subchronic repeated dose study, silver NPs with concentrations of 6.6 Â 10 5 to 2.9 Â 10 6 particles/cm 3 were investigated (Sung et al, 2008). At the highest dosage, changes in lung function and histopathological changes in the lung tissue were detected (Sung et al, 2008). A more detailed analysis of the data revealed bile duct hyperplasia at the highest dose (Sung et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…At the highest dose, increased blood calcium was found, but no adverse effect could be assigned to these observations. In a subchronic repeated dose study, silver NPs with concentrations of 6.6 Â 10 5 to 2.9 Â 10 6 particles/cm 3 were investigated (Sung et al, 2008). At the highest dosage, changes in lung function and histopathological changes in the lung tissue were detected (Sung et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

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Comparative modeling of exposure to airborne nanoparticles released by consumer spray products

2015

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Consumer exposure to sprays containing nano-objects is a continuing concern as a potential health hazard. One potential hazard has been formulated in the overload hypothesis. It describes a volume fraction of the macrophages that is occupied by deposited nanoparticles that leads to reduced macrophage mobility. Subsequent chronic inflammation may then lead to severe health consequences including cancer. To calculate lung deposition of spherical particles, the Multiple-Path Particle Dosimetry (MPPD) model (ARA, Albuquerque, NM) provides different kinds of lung models and age settings. Using the MPPD v 2.11 software, we modeled several consumer-related exposure scenarios. Different body orientations and age groups were investigated. Moreover, a number of materials representing different densities were used, and the exposure calculated using MPPD is compared to the hazard derived from the overload hypothesis. Conditions leading to macrophage overload were found for exposures to high particle doses for prolonged times and repeated exposure. Such conditions are unlikely in the context of regular consumer exposure. The overload hypothesis assumes the particles to be inert and biopersistent, a condition that currently lacks a clear regulatory definition and is valid only for a few selected materials. Furthermore, because of material-specific effects and the possibility of surface adsorption of hazardous chemicals, nano-objects in propellant sprays remain of concern for consumer health.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparative modeling of exposure to airborne nanoparticles released by consumer spray products

2015

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“…Po 12-tygodniowej obserwacji od ustania narażenia ustalono wartość 117 mg/m 3 jako najwyższe stężenie, przy któ-rym nie obserwowano działania toksycznego (no observable adverse effect concentration -NOAEC), biorąc pod uwagę zmiany funkcjonowania płuc (podobne jak we wcześniejszych badaniach (22,6) A.M. Świdwińska-Gajewska, S. Czerczak Nr 6 836 U myszy narażanych inhalacyjnie na nanocząstki srebra (5 nm) przez 10 dni wykazano jedynie łagodny stan zapalny w płucach (7). Odnotowano statystycznie istotny wzrost całkowitej liczby komórek w popłuczy-nach oskrzelowo-pęcherzykowych (bronchoalveolar lavage fluid -BALF) oraz neutrofili, natomiast nie zaobserwowano różnic w aktywności dehydrogenazy mleczanowej (lactate dehydrogenase -LDH) i poziomu białka całkowitego między grupami (7).…”

Section: Narażenie Drogą Inhalacyjnąunclassified

Nanosilver – Harmful effects of biological activity

Świdwińska-Gajewska¹,

Czerczak²

2015

Med Pr

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StreszczenieNanosrebro, zwane także srebrem koloidalnym, od wieków było znane i stosowane do zwalczania chorób i przedłużania trwałości produktów spożywczych. Najczęściej występuje w postaci zawiesiny, składającej się z cząstek wielkości < 100 nm. Dzięki swoim specyficznym właściwościom nanocząstki srebra są wykorzystywane w wielu technologiach do tworzenia wyrobów medycznych, tekstyliów, materiałów przewodzących czy ogniw fotowoltaicznych. Wzrastająca popularność zastosowania nanosrebra przyczynia się do zwiększenia liczby osób pracujących w narażeniu na tę substancję. Potencjalnymi drogami narażenia jest droga inhalacyjna, pokarmowa i dermalna. Nanocząstki srebra mogą być wchłaniane przez płuca, jelita, a także przez skórę do krwiobiegu i w ten sposób docierać do narządów wewnętrznych (wątroby, nerek, śledziony, mózgu, serca i jąder). Nanosrebro może wywoły-wać lekkie podrażnienie oczu i skóry, może także działać jak łagodny alergen na skórę. W narażeniu inhalacyjnym nanocząstki srebra działają głównie na płuca i wątrobę. Wykazano, że nanocząstki srebra mogą działać genotoksycznie na komórki ssaków. Istnieją niepokojące doniesienia na temat szkodliwego działania nanocząstek srebra na rozrodczość zwierząt eksperymentalnych. Narażenie na nanocząstki srebra może działać neurotoksycznie i wpływać na funkcje poznawcze, wywołując zaburzenia pamięci krótkotrwałej i pamięci roboczej. Obowiązujacy obecnie w Polsce normatyw higieniczny dla frakcji wdychalnej srebra (najwyższe dopuszczalne stężenie) wynosi 0,05 mg/m 3 . W świetle wyników badań toksykologicznych nad działaniem biologicznym nanoczą-stek srebra uzasadniona wydaje się potrzeba zaktualizowania normatywów higienicznych dla srebra z wyodrębnieniem frakcji nanocząstek. Med. Pr. 2014;65(6):831-845 Słowa kluczowe: nanocząstki, srebro, nanoobiekty, działanie toksyczne, nanosrebro, srebro koloidalne Abstract Nanosilver, also identified as colloidal silver, has been known and used for ages to combat diseases or prolong food freshness. It usually occurs in the form of a suspension consisting of particles of size < 100 nm. Due to its specific properties, silver nanoparticles are used in many technologies to produce medical devices, textiles, conductive materials or photovoltaic cells. The growing popularity of nanosilver applications increases the number of people occupationally exposed to this substance. Potential exposure routes for silver nanoparticles are through dermal, oral and inhalation pathways. Silver nanoparticles may be absorbed through the lungs, intestine, and through the skin into circulation and thus may reach such organs as the liver, kidney, spleen, brain, heart and testes. Nanosilver may cause mild eyes and skin irritations. It can also act as a mild skin allergen. Inhalation of silver nanoparticles mainly affects the lungs and liver. It has been demonstrated that silver nanoparticles may be genotoxic to mammalian cells. There are some alarming reports on the adverse effects of silver nanoparticles on reproduction of experimental animals. Exposure to...

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“…A recent research on lower group of animal demonstrated that bigger size AgNps causes severe accumulation and damage of GI system and hampers absorption with flow of nutrition to requisite sight [17]. Bigger size AgNps gained entrance into the human body mostly through oral entry portal route and in powdered form it spreads easily in air, soil and water.…”

Section: Journal Of Nutritional Disorders and Therapymentioning

confidence: 99%

Bigger Size Silver Nanoparticles Hamper Mother and Fetus Nutrition after Serial Ingestion of Bolotic Colloidal Nano Silver Stirring Solution through Oral Route: A Revolutionary Research Discovery in Teratogenicity & Toxicity Field

Prakash¹,

Singh²

2017

J Nutr Disorders Ther

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In the field of household products like air conditioner, food protective wrapper silver foil, compressor, fabrics and washing machine manufacture, subscriber or consumer utilized engineered silver nanoparticles of multi bigger size (100 nm size range or more) demand has been extensively increased with increase of negative feedback while using. For the purpose to assess the effect of bigger size silver nano particles on body nutritional status, a serial oral application of silver nanoparticle colloidal stirring cool solution has been made upon pregnant Swiss Albino mice. On serial application (Daily once in morning 9 am continuously from 6 to 19 gestational ages) by repeated gavages during pregnancy pass through portal venous circulation towards liver after gastro intestinal tract absorption hampers mother nutrition by blocking intra hepatic billiary radical and also drastically affect fetal nutrition following same mechanism after crossing blood placental barrier due to gradual accumulation. The present research investigates whether orally induce colloidal silver nanoparticles (AgNps) reach after crossing mother mouse blood placental barrier and induce adverse effects in fetuses from treated group.Pregnant Swiss Albino female mouse from treated group are exposed during the first 13 days of gestation by serial oral bolotic application of bigger size silvernano colloid stirring cool solution at volume of 6, 12, 18, 24 mg/kg b.w. corresponds to individual group when compared with double distilled water vehicle control. Black ash colored bigger silver nanoparticles are identified scattered in maternal and fetal liver, upper GI tissues, placental and umbilical cord tissues of pregnant mother and fetuses after cesarean section and organ removal in gross , histological and TEM view. Particles are found in chronic depositative manner severely blocking portal triad of liver, IHBR and portovenous route. Transmission electron microscopy coupled with energy-dispersive spectroscopy confirmed the size range of particle silvernano from 71 to 1900 nm range.Serial oral ingestion of bigger size AgNps results in increased number of resorbed and malnutriated fetuses associated with reduced mother body and liver (sink & weak) weight and diet. Increased expression of particle accumulation is also detected in the placental cut section of treated groups. The acquired results indicates bigger size nanosilver are able to reach fetus after crossing the pregnant mouse blood placental barrier and portovenous circulation causing hamper of mother and fetus nutrition by obstruction of micro and macro channels. Henceforth as a conclusion, it is wise to take precaution with respect to oral exposure of bigger size silvernanoparticles during pregnancy.

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Lung Function Changes in Sprague-Dawley Rats After Prolonged Inhalation Exposure to Silver Nanoparticles

Cited by 333 publications

References 11 publications

Comparative modeling of exposure to airborne nanoparticles released by consumer spray products

Comparative modeling of exposure to airborne nanoparticles released by consumer spray products

Nanosilver – Harmful effects of biological activity

Bigger Size Silver Nanoparticles Hamper Mother and Fetus Nutrition after Serial Ingestion of Bolotic Colloidal Nano Silver Stirring Solution through Oral Route: A Revolutionary Research Discovery in Teratogenicity & Toxicity Field

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