Lung function six months after severe COVID-19: Does time, in fact, heal all wounds?

Bretas, Daniel Cruz; Leite, Arnaldo Santos; Mancuzo, Eliane Viana; Prata, Tarciane Aline; Andrade, Bruno Horta; Oliveira, Jacqueline Ferreira; Batista, Aline Priscila; Machado-Coelho, George Luiz Lins; Augusto, Valéria Maria; Marinho, Carolina Coimbra

doi:10.1016/j.bjid.2022.102352

Cited by 18 publications

(12 citation statements)

References 30 publications

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“…We identified 4710 records through PubMed, EMBASE, and ScienceDirect database searches. A total of 51 articles (i.e., 33,573 patients) were selected for analysis based on the inclusion and exclusion criteria [ 6 , 15 , 16 , 18 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. The study selection process was documented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis

Deng

et al. 2022

IJERPH

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Although many studies of long COVID-19 were reported, there was a lack of systematic research which assessed the differences of long COVID-19 in regard to what unique SARS-CoV-2 strains caused it. As such, this systematic review and meta-analysis aims to evaluate the characteristics of long COVID-19 that is caused by different SARS-CoV-2 strains. We systematically searched the PubMed, EMBASE, and ScienceDirect databases in order to find cohort studies of long COVID-19 as defined by the WHO (Geneva, Switzerland). The main outcomes were in determining the percentages of long COVID-19 among patients who were infected with different SARS-CoV-2 strains. Further, this study was registered in PROSPERO (CRD42022339964). A total of 51 studies with 33,573 patients was included, of which three studies possessed the Alpha and Delta variants, and five studies possessed the Omicron variant. The highest pooled estimate of long COVID-19 was found in the CT abnormalities (60.5%; 95% CI: 40.4%, 80.6%) for the wild-type strain; fatigue (66.1%; 95% CI: 42.2%, 89.9%) for the Alpha variant; and ≥1 general symptoms (28.4%; 95% CI: 7.9%, 49.0%) for the Omicron variant. The pooled estimates of ≥1 general symptoms (65.8%; 95% CI: 47.7%, 83.9%) and fatigue were the highest symptoms found among patients infected with the Alpha variant, followed by the wild-type strain, and then the Omicron variant. The pooled estimate of myalgia was highest among patients infected with the Omicron variant (11.7%; 95%: 8.3%, 15.1%), compared with those infected with the wild-type strain (9.4%; 95%: 6.3%, 12.5%). The pooled estimate of sleep difficulty was lowest among the patients infected with the Delta variant (2.5%; 95%: 0.2%, 4.9%) when compared with those infected with the wild-type strain (24.5%; 95%: 17.5%, 31.5%) and the Omicron variant (18.7%; 95%: 1.0%, 36.5%). The findings of this study suggest that there is no significant difference between long COVID-19 that has been caused by different strains, except in certain general symptoms (i.e., in the Alpha or Omicron variant) and in sleep difficulty (i.e., the wild-type strain). In the context of the ongoing COVID-19 pandemic and its emerging variants, directing more attention to long COVID-19 that is caused by unique strains, as well as implementing targeted intervention measures to address it are vital.

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Section: Resultsmentioning

confidence: 99%

Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis

Deng

et al. 2022

IJERPH

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“…Our findings indicated a significant increase in dyspnea risk among hospitalized COVID-19 survivors compared with non-hospitalized. A multicenter prospective study by Bretas et al ( 37 ) demonstrated that the prevalence of dyspnea was as high as 64.7% in ward admission. The potential reason why high dyspnea risk presented in hospitalized COVID-19 survivors compared with non-hospitalized is COVID-induced persistent abnormality within the microstructure of the lungs or in the pulmonary vasculature ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Post-acute COVID-19 symptom risk in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis

Yuan

Sun

et al. 2023

Front. Public Health

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BackgroundPost-acute coronavirus disease 2019 (COVID-19) symptoms occurred in most of the COVID-19 survivors. However, few studies have examined the issue of whether hospitalization results in different post-acute COVID-19 symptom risks. This study aimed to compare potential COVID-19 long-term effects in hospitalized and non-hospitalized COVID-19 survivors.MethodsThis study is designed as a systematic review and meta-analysis of observational studies. A systematic search of six databases was performed for identifying articles published from inception until April 20th, 2022, which compared post-acute COVID-19 symptom risk in hospitalized and non-hospitalized COVID-19 survivors using a predesigned search strategy included terms for SARS-CoV-2 (eg, COVID, coronavirus, and 2019-nCoV), post-acute COVID-19 Syndrome (eg, post-COVID, post COVID conditions, chronic COVID symptom, long COVID, long COVID symptom, long-haul COVID, COVID sequelae, convalescence, and persistent COVID symptom), and hospitalization (hospitalized, in hospital, and home-isolated). The present meta-analysis was conducted according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement using R software 4.1.3 to create forest plots. Q statistics and the I2 index were used to evaluate heterogeneity in this meta-analysis.ResultsSix observational studies conducted in Spain, Austria, Switzerland, Canada, and the USA involving 419 hospitalized and 742 non-hospitalized COVID-19 survivors were included. The number of COVID-19 survivors in included studies ranged from 63 to 431, and follow-up data were collected through visits in four studies and another two used an electronic questionnaire, visit and telephone, respectively. Significant increase in the risks of long dyspnea (OR = 3.18, 95% CI = 1.90–5.32), anxiety (OR = 3.09, 95% CI = 1.47–6.47), myalgia (OR = 2.33, 95% CI = 1.02–5.33), and hair loss (OR = 2.76, 95% CI = 1.07–7.12) risk were found in hospitalized COVID-19 survivors compared with outpatients. Conversely, persisting ageusia risk was significantly reduced in hospitalized COVID-19 survivors than in non-hospitalized patients.ConclusionThe findings suggested that special attention and patient-centered rehabilitation service based on a needs survey should be provided for hospitalized COVID-19 survivors who experienced high post-acute COVID-19 symptoms risk.

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“…Results of all included studies can be found in Table S1 . All studies included a population with a mean or median age between 47 and 66 years and most studies had an equal distribution of males and females.The majority of the studies were conducted in Europe (n = 26) [ [3] , [4] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] ],49,51,56,60,62,65,66,67,69,70,74,76,77,79,80,81,83,84], six were conducted in North America [ [59] , [60] , [61] , [62] , [63] , [64] ], four in South America [ [65] , [66] , [67] , [68] ] and eleven in Asia [ [16] , [17] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] ]. The population of the studies varied between 17 and 1733 with a mean of 177 participants.…”

Section: Resultsmentioning

confidence: 99%

Pulmonary function 3–6 months after acute COVID-19: A systematic review and multicentre cohort study

Cornelissen,

Leliveld,

Baalbaki

et al. 2024

Heliyon

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Lung function six months after severe COVID-19: Does time, in fact, heal all wounds?

Cited by 18 publications

References 30 publications

Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis

Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis

Post-acute COVID-19 symptom risk in hospitalized and non-hospitalized COVID-19 survivors: A systematic review and meta-analysis

Pulmonary function 3–6 months after acute COVID-19: A systematic review and multicentre cohort study

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