Lung injury induced by Bisphenol A: A food contaminant, is ameliorated by selenium supplementation

Abedelhaffez, Azza Salaheldien; El-Aziz, Ebtihal A. Abd; Aziz, Mohamed Abdel; Ahmed, Abdel Ghaffar M.

doi:10.1016/j.pathophys.2017.02.003

Cited by 36 publications

(20 citation statements)

References 56 publications

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“…In the current study, BPA increased Reactive Oxygen Species (ROS) production as assessed by the measurement of the end product of lipid peroxidation such as the oxidized lipids such as OXPL-LDL, MDA-LDL, CML-LDL, and HNE-LDL were high. These results are in agreement with the previous studies Abedelhaffeza et al [16]showed an increase in lipid peroxidation. Ansoumane et al [17] reported, an increased in lipid peroxidation (LPO).…”

Section: Discussionsupporting

confidence: 94%

Bisphenol a Exposure Causes Increased Oxidation of Low Density Lipoprotein (LDL) and Its Abduct in Rats

Oguazu

Ezeonu

Dike

et al. 2021

AJRB

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Background and Objectives: Living organisms are exposed to oxidant agents constantly from both endogenous and exogenous sources. One of such oxidant agent is Bisphenol A (BPA) and its exposure is capable to modify biomolecules and induce damages. Bisphenol A (BPA) is a contaminant with increasing exposure. It exerts toxic effects on cells. This study investigates the possibility of BPA exposure on Low Density Lipoprotein (LDL) perturbations at prevailing low exposure doses in female albino Wistar rats, following exposure for the period of three (3) month. Materials and Methods: Total 12 groups were formed; out of which 11 experimental groups, each containing 10non-pregnant female rats were administered; 0.05, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, and 1 mg of BPA/kgbw/day. To the 12th control group was given water. Blood was collected from animals at the end of every week of the study and serum sample specimens analyzed by routine diagnostic procedures for oxidized LDL such as malondialdehyde modified- LDL (MDA-LDL), oxidized phospholipids LDL (OX-PL LDL), N (epsilon) (carboxymethyl) lysine-modified-LDL (CML LDL) and 4-hydroxynonenal-LDL (HNE-LDL) using Autochemical Analyzer. Results: Significantly increased concentrations of serum oxidized LDL such as MDA-LDL, OX-PL LDL, CML LDL and HNE-LDL were observed at all concentrations of BPA exposure. Conclusion: Bisphenol A alters oxidized LDL such as MDA-LDL, OX-PL LDL, CML LDL and HNE-LDL balance and causes disturbance of internal oxidative statues.

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Section: Discussionsupporting

confidence: 94%

Bisphenol a Exposure Causes Increased Oxidation of Low Density Lipoprotein (LDL) and Its Abduct in Rats

Oguazu

Ezeonu

Dike

et al. 2021

AJRB

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“…Of course, BPA affects also other internal organs, including, among others, the liver [62], heart [63], endocrine glands [64], kidneys [65] and lungs [66], leading to disturbances in their functioning [43,44]. In turn, epidemiological studies on human population have shown correlation between the degree of exposure to BPA and risk of obesity, diabetes, hypertension, cancer and many other pathological processes [67,68].…”

Section: Species Localization Referencesmentioning

confidence: 99%

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Szymańska

Makowska

Całka

et al. 2020

IJMS

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The enteric nervous system (ENS), located in the wall of the gastrointestinal (GI) tract, is characterized by complex organization and a high degree of neurochemical diversity of neurons. One of the less known active neuronal substances found in the enteric neurons is neuregulin 1 (NRG1), a factor known to be involved in the assurance of normal development of the nervous system. During the study, made up using the double immunofluorescence technique, the presence of NRG1 in the ENS of the selected segment of porcine large intestine (caecum, ascending and descending colon) was observed in physiological conditions, as well as under the impact of low and high doses of bisphenol A (BPA) which is commonly used in the production of plastics. In control animals in all types of the enteric plexuses, the percentage of NRG1-positive neurons oscillated around 20% of all neurons. The administration of BPA caused an increase in the number of NRG1-positive neurons in all types of the enteric plexuses and in all segments of the large intestine studied. The most visible changes were noted in the inner submucous plexus of the ascending colon, where in animals treated with high doses of BPA, the percentage of NRG1-positive neurons amounted to above 45% of all neuronal cells. The mechanisms of observed changes are not entirely clear, but probably result from neurotoxic, neurodegenerative and/or proinflammatory activity of BPA and are protective and adaptive in nature.

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“…In addition, previous studies were occurred on the protective effects of selenium alone or vitamin E alone on BPA-treated animals. The results showed that selenium or vitamin E ameliorated the toxicity induced by BPA in liver, testis and lungs ( 25 – 27 ). Growing investigations had shown that both selenium and vitamin E are more powerful to scavenge ROS synergistically ( 16 , 28 , 29 ).…”

Section: Introductionmentioning

confidence: 99%

Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-Induced Oxidative Stress in Wistar Albinos Rats

et al. 2018

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Bisphenol A, an everywhere chemical, is applied as a plasticizer in polycarbonate plastics, which often used in our everyday products and in epoxy resins as protective coatings and linings for food and beverage cans for decades. Human exposure to BPA may lead to adverse effects by interfering with oestrogen receptors. Our present study was conducted to investigate the protective effects of selenium (Se) and vitamin E (Vit E) on BPA-induced damage in the liver of male rats. Animals were randomly divided into four groups: the first group received olive oil and served as control. The second group received both (Se + Vit E) (0.5 mg/kg diet; 100 mg/kg of diet). The third one treated orally by (10 mg/kg b.w.) of BPA. The last group received (Se + Vit E) (0.5 mg/kg diet; 100 mg/kg of diet) concomitantly with (10 mg/kg b.w.) BPA. Exposure to BPA for three weeks engendered a hepatic disorder. An increased AST and ALT enzymatic activity was noticed in BPA-treated group as compared to other groups. Furthermore, a change in glucose, cholesterol, LDL-C, HDL-C, albumin, and bilirubin level was remarkable. Moreover, exposure to BPA increased malondialdehyde levels while reduced gluthatione content was decreased in the liver homogenate. A decrease in glutathione peroxidase, glutathione s-transferase and catalase activities was observed in the same group. Administration of selenium and vitamin E through the diet in BPA treated rats ameliorated the biochemical parameters cited above. In addition, an improvement in activities of liver enzymes was recorded. The histological findings confirmed the biochemical results. The model of this study that we employed characterized the relationships between BPA-induced hepatotoxicity and its alleviation by natural antioxidants like selenium and vitamin E.

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Lung injury induced by Bisphenol A: A food contaminant, is ameliorated by selenium supplementation

Cited by 36 publications

References 56 publications

Bisphenol a Exposure Causes Increased Oxidation of Low Density Lipoprotein (LDL) and Its Abduct in Rats

Bisphenol a Exposure Causes Increased Oxidation of Low Density Lipoprotein (LDL) and Its Abduct in Rats

The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine

Modulatory Role of Selenium and Vitamin E, Natural Antioxidants, against Bisphenol A-Induced Oxidative Stress in Wistar Albinos Rats

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